Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07237 | P4HB | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) … | Homo sapiens (Human) | 508 aa |
Protein Details: P07237 (P4HB)
Protein Information
| Accession | P07237 |
|---|---|
| Protein Names | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) |
| Gene Symbol | P4HB |
| Organism | Homo sapiens (Human) |
| Length | 508 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLRRALLCLA11VAALVRADAP21EEEDHVLVLR31KSNFAEALAA41HKYLLVEFYA
51-10051PWCGHCKALA61PEYAKAAGKL71KAEGSEIRLA81KVDATEESDL91AQQYGVRGYP
101-150101TIKFFRNGDT111ASPKEYTAGR121EADDIVNWLK131KRTGPAATTL141PDGAAAESLV
151-200151ESSEVAVIGF161FKDVESDSAK171QFLQAAEAID181DIPFGITSNS191DVFSKYQLDK
201-250201DGVVLFKKFD211EGRNNFEGEV221TKENLLDFIK231HNQLPLVIEF241TEQTAPKIFG
251-300251GEIKTHILLF261LPKSVSDYDG271KLSNFKTAAE281SFKGKILFIF291IDSDHTDNQR
301-350301ILEFFGLKKE311ECPAVRLITL321EEEMTKYKPE331SEELTAERIT341EFCHRFLEGK
351-400351IKPHLMSQEL361PEDWDKQPVK371VLVGKNFEDV381AFDEKKNVFV391EFYAPWCGHC
401-450401KQLAPIWDKL411GETYKDHENI421VIAKMDSTAN431EVEAVKVHSF441PTLKFFPASA
451-500451DRTVIDYNGE461RTLDGFKKFL471ESGGQDGAGD481DDDLEDLEEA491EEPDMEEDDD
501-508501QKAVKDEL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.71
|
|
| 53 | - | - | - |
Deep-Palm: 0.85
|
|
| 56 | - | - | - |
Deep-Palm: 0.88
|
|
| 312 | SWISSPALM DBPTM CYSMODDB | Thioredoxin-like domain | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.97
|
| 343 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.90
|
|
| 397 | - | - | - |
Deep-Palm: 0.17
|
|
| 400 | - | - | - |
Deep-Palm: 0.18
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
LNCaP
Specificity: 0.429
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.286
2/2 (100.0%)
1
U937 cell
Specificity: 0.143
1/1 (100.0%)
1
293T cell
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 161 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 300 | R → C | 0.002294 | SNP | Missense Mutation | OV |