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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P07237 P4HB; ERBA2L; PDI; PDIA1; PO4DB Protein disulfide-isomerase (PDI) (EC 5.3.4.1) … Homo sapiens (Human) 508 aa

Protein Details: P07237 (P4HB)

Protein Information
Accession P07237
Protein Names Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene Symbol P4HB; ERBA2L; PDI; PDIA1; PO4DB
Organism Homo sapiens (Human)
Length 508 aa
Isoforms No isoforms
Related PMIDs 21076176 29733200 31251020 31382980 32944167
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.643
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.643
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.179
10/10 (100.0%)
4
293T cells
Specificity: 0.071
4/10 (40.0%)
3
PC3 cells
Specificity: 0.054
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.036
2/25 (8.0%)
1
U937 cells
Specificity: 0.018
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLRRALLCLA11VAALVRADAP21EEEDHVLVLR31KSNFAEALAA41HKYLLVEFYA
51-10051PWCGHCKALA61PEYAKAAGKL71KAEGSEIRLA81KVDATEESDL91AQQYGVRGYP
101-150101TIKFFRNGDT111ASPKEYTAGR121EADDIVNWLK131KRTGPAATTL141PDGAAAESLV
151-200151ESSEVAVIGF161FKDVESDSAK171QFLQAAEAID181DIPFGITSNS191DVFSKYQLDK
201-250201DGVVLFKKFD211EGRNNFEGEV221TKENLLDFIK231HNQLPLVIEF241TEQTAPKIFG
251-300251GEIKTHILLF261LPKSVSDYDG271KLSNFKTAAE281SFKGKILFIF291IDSDHTDNQR
301-350301ILEFFGLKKE311ECPAVRLITL321EEEMTKYKPE331SEELTAERIT341EFCHRFLEGK
351-400351IKPHLMSQEL361PEDWDKQPVK371VLVGKNFEDV381AFDEKKNVFV391EFYAPWCGHC
401-450401KQLAPIWDKL411GETYKDHENI421VIAKMDSTAN431EVEAVKVHSF441PTLKFFPASA
451-500451DRTVIDYNGE461RTLDGFKKFL471ESGGQDGAGD481DDDLEDLEEA491EEPDMEEDDD
501-508501QKAVKDEL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
8 Prediction (High) - -
312 CYSMODDB SWISSPALM DBPTM Prediction (Medium) Thioredoxin-like domain -
343 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
161 F → C 0.002545 SNP Missense Mutation GBM
300 R → C 0.002294 SNP Missense Mutation OV