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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P07357 C8A Complement component C8 alpha chain … Homo sapiens (Human) 584 aa

Protein Details: P07357 (C8A)

Protein Information
Accession P07357
Protein Names Complement component C8 alpha chain (Complement component 8 subunit alpha)
Gene Symbol C8A
Organism Homo sapiens (Human)
Length 584 aa
Isoforms No isoforms
Related PMIDs 33636221
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
1
Liver membrane
Specificity: 1.000
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MFAVVFFILS11LMTCQPGVTA21QEKVNQRVRR31AATPAAVTCQ41LSNWSEWTDC
51-10051FPCQDKKYRH61RSLLQPNKFG71GTICSGDIWD81QASCSSSTTC91VRQAQCGQDF
101-150101QCKETGRCLK111RHLVCNGDQD121CLDGSDEDDC131EDVRAIDEDC141SQYEPIPGSQ
151-200151KAALGYNILT161QEDAQSVYDA171SYYGGQCETV181YNGEWRELRY191DSTCERLYYG
201-250201DDEKYFRKPY211NFLKYHFEAL221ADTGISSEFY231DNANDLLSKV241KKDKSDSFGV
251-300251TIGIGPAGSP261LLVGVGVSHS271QDTSFLNELN281KYNEKKFIFT291RIFTKVQTAH
301-350301FKMRKDDIML311DEGMLQSLME321LPDQYNYGMY331AKFINDYGTH341YITSGSMGGI
351-400351YEYILVIDKA361KMESLGITSR371DITTCFGGSL381GIQYEDKINV391GGGLSGDHCK
401-450401KFGGGKTERA411RKAMAVEDII421SRVRGGSSGW431SGGLAQNRST441ITYRSWGRSL
451-500451KYNPVVIDFE461MQPIHEVLRH471TSLGPLEAKR481QNLRRALDQY491LMEFNACRCG
501-550501PCFNNGVPIL511EGTSCRCQCR521LGSLGAACEQ531TQTEGAKADG541SWSCWSSWSV
551-584551CRAGIQERRR561ECDNPAPQNG571GASCPGRKVQ581TQAC
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
14 Prediction (Medium) - -
39 Prediction (Medium) - -
375 Prediction (Low) - -
399 Prediction (Medium) - -
515 Prediction (Low) - -
517 Prediction (Low) - -
528 Prediction (Medium) - -
551 Prediction (Low) - -
574 Prediction (Low) - -
584 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
50 C → Y 0.001764 SNP Missense Mutation LUAD
111 R → C 0.001887 SNP Missense Mutation UCEC
124 G → C 0.002033 SNP Missense Mutation LUSC
130 C → Y 0.001969 SNP Missense Mutation HNSC
143 Y → C 0.002033 SNP Missense Mutation LUSC
185 W → C 0.001014 SNP Missense Mutation BRCA
253 G → C 0.001764 SNP Missense Mutation LUAD
393 G → C 0.001887 SNP Missense Mutation UCEC
472 S → C 0.001969 SNP Missense Mutation LGG
484 R → C 0.001887 SNP Missense Mutation UCEC
517 C → G 0.002294 SNP Missense Mutation OV
520 R → C 0.001887 SNP Missense Mutation UCEC
562 C → G 0.005618 SNP Missense Mutation PAAD