Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07550 | ADRB2 | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) … | Homo sapiens (Human) | 413 aa |
Protein Details: P07550 (ADRB2)
Protein Information
| Accession | P07550 |
|---|---|
| Protein Names | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) |
| Gene Symbol | ADRB2 |
| Organism | Homo sapiens (Human) |
| Length | 413 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGQPGNGSAF11LLAPNGSHAP21DHDVTQERDE31VWVVGMGIVM41SLIVLAIVFG
51-10051NVLVITAIAK61FERLQTVTNY71FITSLACADL81VMGLAVVPFG91AAHILMKMWT
101-150101FGNFWCEFWT111SIDVLCVTAS121IETLCVIAVD131RYFAITSPFK141YQSLLTKNKA
151-200151RVIILMVWIV161SGLTSFLPIQ171MHWYRATHQE181AINCYANETC191CDFFTNQAYA
201-250201IASSIVSFYV211PLVIMVFVYS221RVFQEAKRQL231QKIDKSEGRF241HVQNLSQVEQ
251-300251DGRTGHGLRR261SSKFCLKEHK271ALKTLGIIMG281TFTLCWLPFF291IVNIVHVIQD
301-350301NLIRKEVYIL311LNWIGYVNSG321FNPLIYCRSP331DFRIAFQELL341CLRRSSLKAY
351-400351GNGYSSNGNT361GEQSGYHVEQ371EKENKLLCED381LPGTEDFVGH391QGTVPSDNID
401-413401SQGRNCSTND411SLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 77 | - | - | - |
Deep-Palm: 0.73
|
|
| 106 | - | - | - |
Deep-Palm: 0.02
|
|
| 116 | - | - | - |
Deep-Palm: 0.02
|
|
| 125 | - | - | - |
Deep-Palm: 0.34
|
|
| 184 | - | - | - |
Deep-Palm: 0.02
|
|
| 190 | - | - | - |
Deep-Palm: 0.04
|
|
| 191 | - | - | - |
Deep-Palm: 0.02
|
|
| 265 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
| 285 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.16
|
|
| 327 | - | - | - |
Deep-Palm: 0.11
|
|
| 341 | DBPTM SWISSPALM | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.96
Deep-Palm: 0.96
|
| 378 | - | - | - |
Deep-Palm: 0.81
|
|
| 406 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
PC3
Specificity: 0.500
3/3 (100.0%)
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.167
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 49 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 91 | A → Cfs*23 | 0.003460 | INS | Frame Shift Ins | CESC |
| 106 | C → C | 0.001887 | SNP | Silent | UCEC |
| 184 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 185 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 304 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 343 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 343 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 343 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 190* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |