Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07737 | PFN1 | Profilin-1 (Epididymis tissue protein Li … | Homo sapiens (Human) | 140 aa |
Protein Details: P07737 (PFN1)
Protein Information
| Accession | P07737 |
|---|---|
| Protein Names | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) |
| Gene Symbol | PFN1 |
| Organism | Homo sapiens (Human) |
| Length | 140 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 25914232 29733200 31251020 31382980 33636221 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGWNAYIDN11LMADGTCQDA21AIVGYKDSPS31VWAAVPGKTF41VNITPAEVGV
51-10051LVGKDRSSFY61VNGLTLGGQK71CSVIRDSLLQ81DGEFSMDLRT91KSTGGAPTFN
101-140101VTVTKTDKTL111VLLMGKEGVH121GGLINKKCYE131MASHLRRSQY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | Profilin superfamily Profilin Profilin1/2/3, vertebrate PROFILIN Dynein light chain 2a, cytoplasmic | - |
Unknown
(32651440)
|
Deep-Palm: 0.33
|
|
| 71 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.92
|
|
| 128 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.71
Deep-Palm: 0.06
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.200
3/3 (100.0%)
2
LNCaP
Specificity: 0.133
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.133
2/2 (100.0%)
1
U937 cell
Specificity: 0.067
1/1 (100.0%)
1
EC cell
Specificity: 0.067
1/1 (100.0%)
1
293T cell
Specificity: 0.067
1/1 (100.0%)
1
heart
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 17 | C → _D27del | 0.002288 | DEL | In Frame Del | STAD |
| ? | ? → ? | 0.002427 | SNP | Missense Mutation | BLCA |