Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07814 | EPRS1; EPRS; GLNS; PARS; QARS; QPRS; PIG32 | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA … | Homo sapiens (Human) | 1512 aa |
Protein Details: P07814 (EPRS1)
Protein Information
| Accession | P07814 |
|---|---|
| Protein Names | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] |
| Gene Symbol | EPRS1; EPRS; GLNS; PARS; QARS; QPRS; PIG32 |
| Organism | Homo sapiens (Human) |
| Length | 1512 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 29575903 29733200 31251020 31382980 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.500
24/46 (52.2%)
10
HAP1 cells
Specificity: 0.208
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.083
4/25 (16.0%)
4
293T cells
Specificity: 0.083
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.083
4/4 (100.0%)
1
U937 cells
Specificity: 0.021
1/1 (100.0%)
1
HeLa cells
Specificity: 0.021
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MATLSLTVNS11GDPPLGALLA21VEHVKDDVSI31SVEEGKENIL41HVSENVIFTD
51-10051VNSILRYLAR61VATTAGLYGS71NLMEHTEIDH81WLEFSATKLS91SCDSFTSTIN
101-150101ELNHCLSLRT111YLVGNSLSLA121DLCVWATLKG131NAAWQEQLKQ141KKAPVHVKRW
151-200151FGFLEAQQAF161QSVGTKWDVS171TTKARVAPEK181KQDVGKFVEL191PGAEMGKVTV
201-250201RFPPEASGYL211HIGHAKAALL221NQHYQVNFKG231KLIMRFDDTN241PEKEKEDFEK
251-300251VILEDVAMLH261IKPDQFTYTS271DHFETIMKYA281EKLIQEGKAY291VDDTPAEQMK
301-350301AEREQRIDSK311HRKNPIEKNL321QMWEEMKKGS331QFGQSCCLRA341KIDMSSNNGC
351-400351MRDPTLYRCK361IQPHPRTGNK371YNVYPTYDFA381CPIVDSIEGV391THALRTTEYH
401-450401DRDEQFYWII411EALGIRKPYI421WEYSRLNLNN431TVLSKRKLTW441FVNEGLVDGW
451-500451DDPRFPTVRG461VLRRGMTVEG471LKQFIAAQGS481SRSVVNMEWD491KIWAFNKKVI
501-550501DPVAPRYVAL511LKKEVIPVNV521PEAQEEMKEV531AKHPKNPEVG541LKPVWYSPKV
551-600551FIEGADAETF561SEGEMVTFIN571WGNLNITKIH581KNADGKIISL591DAKLNLENKD
601-650601YKKTTKVTWL611AETTHALPIP621VICVTYEHLI631TKPVLGKDED641FKQYVNKNSK
651-700651HEELMLGDPC661LKDLKKGDII671QLQRRGFFIC681DQPYEPVSPY691SCKEAPCVLI
701-750701YIPDGHTKEM711PTSGSKEKTK721VEATKNETSA731PFKERPTPSL741NNNCTTSEDS
751-800751LVLYNRVAVQ761GDVVRELKAK771KAPKEDVDAA781VKQLLSLKAE791YKEKTGQEYK
801-850801PGNPPAEIGQ811NISSNSSASI821LESKSLYDEV831AAQGEVVRKL841KAEKSPKAKI
851-900851NEAVECLLSL861KAQYKEKTGK871EYIPGQPPLS881QSSDSSPTRN891SEPAGLETPE
901-950901AKVLFDKVAS911QGEVVRKLKT921EKAPKDQVDI931AVQELLQLKA941QYKSLIGVEY
951-1000951KPVSATGAED961KDKKKKEKEN971KSEKQNKPQK981QNDGQRKDPS991KNQGGGLSSS
1001-10501001GAGEGQGPKK1011QTRLGLEAKK1021EENLADWYSQ1031VITKSEMIEY1041HDISGCYILR
1051-11001051PWAYAIWEAI1061KDFFDAEIKK1071LGVENCYFPM1081FVSQSALEKE1091KTHVADFAPE
1101-11501101VAWVTRSGKT1111ELAEPIAIRP1121TSETVMYPAY1131AKWVQSHRDL1141PIKLNQWCNV
1151-12001151VRWEFKHPQP1161FLRTREFLWQ1171EGHSAFATME1181EAAEEVLQIL1191DLYAQVYEEL
1201-12501201LAIPVVKGRK1211TEKEKFAGGD1221YTTTIEAFIS1231ASGRAIQGGT1241SHHLGQNFSK
1251-13001251MFEIVFEDPK1261IPGEKQFAYQ1271NSWGLTTRTI1281GVMTMVHGDN1291MGLVLPPRVA
1301-13501301CVQVVIIPCG1311ITNALSEEDK1321EALIAKCNDY1331RRRLLSVNIR1341VRADLRDNYS
1351-14001351PGWKFNHWEL1361KGVPIRLEVG1371PRDMKSCQFV1381AVRRDTGEKL1391TVAENEAETK
1401-14501401LQAILEDIQV1411TLFTRASEDL1421KTHMVVANTM1431EDFQKILDSG1441KIVQIPFCGE
1451-15001451IDCEDWIKKT1461TARDQDLEPG1471APSMGAKSLC1481IPFKPLCELQ1491PGAKCVCGKN
1501-15121501PAKYYTLFGR1511SY
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 92 | Prediction (Low) | - | - |
| 123 | Prediction (Low) | - | - |
| 336 | Prediction (High) | - | - |
| 337 | Prediction (High) | - | - |
| 350 | Prediction (High) | - | - |
| 660 | Experimental Prediction (Low) | tRNA synthetases class I (E and Q) anti-codon binding domain | 37611173 |
| 680 | Prediction (Low) | - | - |
| 856 | Prediction (High) | - | - |
| 1046 | Prediction (Low) | - | - |
| 1076 | Prediction (Medium) | - | - |
| 1148 | Prediction (Medium) | - | - |
| 1301 | Experimental CYSMODDB SWISSPALM DBPTM | - | 29575903 |
| 1309 | Experimental CYSMODDB SWISSPALM DBPTM | - | 29575903 |
| 1327 | Prediction (Medium) | - | - |
| 1377 | Prediction (High) | - | - |
| 1480 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Prolyl-tRNA synthetase C-terminal | - |
| 1487 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Prolyl-tRNA synthetase C-terminal | - |
| 1495 | Prediction (Medium) | - | - |
| 1497 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 56 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 301 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 303 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 371 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 391 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 391 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 435 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 464 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 465 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 482 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 556 | C → F | 0.003559 | SNP | Missense Mutation | KIRP |
| 629 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 629 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 653 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 687 | C → Y | 0.002427 | SNP | Missense Mutation | BLCA |
| 697 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 765 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 765 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 990 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1046 | C → C | 0.017544 | SNP | Silent | UCS |
| 1119 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 1119 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1119 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1127 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1127 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 1152 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1165 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1327 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1340 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1510 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| ? | ? → ? | 0.002427 | SNP | Missense Mutation | BLCA |