Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P07858 CTSB; CPSB Cathepsin B (EC 3.4.22.1) (APP … Homo sapiens (Human) 339 aa

Protein Details: P07858 (CTSB)

Protein Information
Accession P07858
Protein Names Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Gene Symbol CTSB; CPSB
Organism Homo sapiens (Human)
Length 339 aa
Isoforms No isoforms
Related PMIDs 24357059 31251020
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.960
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.960
24/46 (52.2%)
1
Endothelial cells
Specificity: 0.040
1/2 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MWQLWASLCC11LLVLANARSR21PSFHPLSDEL31VNYVNKRNTT41WQAGHNFYNV
51-10051DMSYLKRLCG61TFLGGPKPPQ71RVMFTEDLKL81PASFDAREQW91PQCPTIKEIR
101-150101DQGSCGSCWA111FGAVEAISDR121ICIHTNAHVS131VEVSAEDLLT141CCGSMCGDGC
151-200151NGGYPAEAWN161FWTRKGLVSG171GLYESHVGCR181PYSIPPCEHH191VNGSRPPCTG
201-250201EGDTPKCSKI211CEPGYSPTYK221QDKHYGYNSY231SVSNSEKDIM241AEIYKNGPVE
251-300251GAFSVYSDFL261LYKSGVYQHV271TGEMMGGHAI281RILGWGVENG291TPYWLVANSW
301-339301NTDWGDNGFF311KILRGQDHCG321IESEVVAGIP331RTDQYWEKI
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
9 Prediction (High) - -
10 Prediction (High) - -
59 Prediction (High) - -
93 Prediction (Medium) - -
319 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
59 C → F 0.002976 SNP Missense Mutation KIRC
105 C → R 0.002506 SNP Missense Mutation COAD
154 Y → C 0.002747 SNP Missense Mutation LIHC
179 C → Y 0.002506 SNP Missense Mutation COAD
198 C → W 0.002141 SNP Missense Mutation SKCM
207 C → G 0.002545 SNP Missense Mutation GBM
299 S → C 0.002033 SNP Missense Mutation LUSC