Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07858 | CTSB | Cathepsin B (EC 3.4.22.1) (APP … | Homo sapiens (Human) | 339 aa |
Protein Details: P07858 (CTSB)
Protein Information
| Accession | P07858 |
|---|---|
| Protein Names | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] |
| Gene Symbol | CTSB |
| Organism | Homo sapiens (Human) |
| Length | 339 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWQLWASLCC11LLVLANARSR21PSFHPLSDEL31VNYVNKRNTT41WQAGHNFYNV
51-10051DMSYLKRLCG61TFLGGPKPPQ71RVMFTEDLKL81PASFDAREQW91PQCPTIKEIR
101-150101DQGSCGSCWA111FGAVEAISDR121ICIHTNAHVS131VEVSAEDLLT141CCGSMCGDGC
151-200151NGGYPAEAWN161FWTRKGLVSG171GLYESHVGCR181PYSIPPCEHH191VNGSRPPCTG
201-250201EGDTPKCSKI211CEPGYSPTYK221QDKHYGYNSY231SVSNSEKDIM241AEIYKNGPVE
251-300251GAFSVYSDFL261LYKSGVYQHV271TGEMMGGHAI281RILGWGVENG291TPYWLVANSW
301-339301NTDWGDNGFF311KILRGQDHCG321IESEVVAGIP331RTDQYWEKI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.92
Deep-Palm: 0.04
|
|
| 10 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.92
Deep-Palm: 0.04
|
|
| 59 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.85
|
|
| 93 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.78
|
|
| 105 | - | - | - |
Deep-Palm: 0.15
|
|
| 108 | - | - | - |
Deep-Palm: 0.22
|
|
| 122 | - | - | - |
Deep-Palm: 0.32
|
|
| 141 | - | - | - |
Deep-Palm: 0.29
|
|
| 142 | - | - | - |
Deep-Palm: 0.47
|
|
| 146 | - | - | - |
Deep-Palm: 0.42
|
|
| 150 | - | - | - |
Deep-Palm: 0.16
|
|
| 179 | - | - | - |
Deep-Palm: 0.66
|
|
| 187 | - | - | - |
Deep-Palm: 0.08
|
|
| 198 | - | - | - |
Deep-Palm: 0.06
|
|
| 207 | - | - | - |
Deep-Palm: 0.11
|
|
| 211 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.09
|
|
| 319 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.72
Deep-Palm: 0.72
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
cerebral cortex
Specificity: 0.300
3/3 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
1
HUVECs
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.400
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 59 | C → F | 0.002976 | SNP | Missense Mutation | KIRC |
| 105 | C → R | 0.002506 | SNP | Missense Mutation | COAD |
| 154 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 179 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 198 | C → W | 0.002141 | SNP | Missense Mutation | SKCM |
| 207 | C → G | 0.002545 | SNP | Missense Mutation | GBM |
| 299 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |