Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P07947 YES1; YES Tyrosine-protein kinase Yes (EC 2.7.10.2) … Homo sapiens (Human) 543 aa

Protein Details: P07947 (YES1)

Protein Information
Accession P07947
Protein Names Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene Symbol YES1; YES
Organism Homo sapiens (Human)
Length 543 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 22496122 29575903 29733200 31251020 32944167 33636221 36430497 37611173
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.547
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
29
LNCaP cells
Specificity: 0.547
29/46 (63.0%)
4
PC3 cells
Specificity: 0.075
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.075
4/10 (40.0%)
4
293T cells
Specificity: 0.075
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.075
4/4 (100.0%)
3
Jurkat T cells
Specificity: 0.057
3/25 (12.0%)
2
DU145 cells
Specificity: 0.038
2/2 (100.0%)
1
HeLa cells
Specificity: 0.019
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.019
1/2 (50.0%)
1
Liver membrane
Specificity: 0.019
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGCIKSKENK11SPAIKYRPEN21TPEPVSTSVS31HYGAEPTTVS41PCPSSSAKGT
51-10051AVNFSSLSMT61PFGGSSGVTP71FGGASSSFSV81VPSSYPAGLT91GGVTIFVALY
101-150101DYEARTTEDL111SFKKGERFQI121INNTEGDWWE131ARSIATGKNG141YIPSNYVAPA
151-200151DSIQAEEWYF161GKMGRKDAER171LLLNPGNQRG181IFLVRESETT191KGAYSLSIRD
201-250201WDEIRGDNVK211HYKIRKLDNG221GYYITTRAQF231DTLQKLVKHY241TEHADGLCHK
251-300251LTTVCPTVKP261QTQGLAKDAW271EIPRESLRLE281VKLGQGCFGE291VWMGTWNGTT
301-350301KVAIKTLKPG311TMMPEAFLQE321AQIMKKLRHD331KLVPLYAVVS341EEPIYIVTEF
351-400351MSKGSLLDFL361KEGDGKYLKL371PQLVDMAAQI381ADGMAYIERM391NYIHRDLRAA
401-450401NILVGENLVC411KIADFGLARL421IEDNEYTARQ431GAKFPIKWTA441PEAALYGRFT
451-500451IKSDVWSFGI461LQTELVTKGR471VPYPGMVNRE481VLEQVERGYR491MPCPQGCPES
501-543501LHELMNLCWK511KDPDERPTFE521YIQSFLEDYF531TATEPQYQPG541ENL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
3 Prediction (High) - -
42 Experimental DBPTM SWISSPALM - 19801377
248 Experimental - 37611173
410 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
75 S → C 0.002427 SNP Missense Mutation BLCA
199 R → C 0.002545 SNP Missense Mutation GBM
223 Y → _I224insYCSWRLQHLSL 0.002545 INS In Frame Ins GBM
489 Y → C 0.002427 SNP Missense Mutation BLCA
? ? → ? 0.001887 SNP Missense Mutation UCEC