Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07947 | YES1 | Tyrosine-protein kinase Yes (EC 2.7.10.2) … | Homo sapiens (Human) | 543 aa |
Protein Details: P07947 (YES1)
Protein Information
| Accession | P07947 |
|---|---|
| Protein Names | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) |
| Gene Symbol | YES1 |
| Organism | Homo sapiens (Human) |
| Length | 543 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 29575903 29733200 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCIKSKENK11SPAIKYRPEN21TPEPVSTSVS31HYGAEPTTVS41PCPSSSAKGT
51-10051AVNFSSLSMT61PFGGSSGVTP71FGGASSSFSV81VPSSYPAGLT91GGVTIFVALY
101-150101DYEARTTEDL111SFKKGERFQI121INNTEGDWWE131ARSIATGKNG141YIPSNYVAPA
151-200151DSIQAEEWYF161GKMGRKDAER171LLLNPGNQRG181IFLVRESETT191KGAYSLSIRD
201-250201WDEIRGDNVK211HYKIRKLDNG221GYYITTRAQF231DTLQKLVKHY241TEHADGLCHK
251-300251LTTVCPTVKP261QTQGLAKDAW271EIPRESLRLE281VKLGQGCFGE291VWMGTWNGTT
301-350301KVAIKTLKPG311TMMPEAFLQE321AQIMKKLRHD331KLVPLYAVVS341EEPIYIVTEF
351-400351MSKGSLLDFL361KEGDGKYLKL371PQLVDMAAQI381ADGMAYIERM391NYIHRDLRAA
401-450401NILVGENLVC411KIADFGLARL421IEDNEYTARQ431GAKFPIKWTA441PEAALYGRFT
451-500451IKSDVWSFGI461LQTELVTKGR471VPYPGMVNRE481VLEQVERGYR491MPCPQGCPES
501-543501LHELMNLCWK511KDPDERPTFE521YIQSFLEDYF531TATEPQYQPG541ENL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
|
| 42 | DBPTM SWISSPALM | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.88
|
| 248 | - |
HeLa
(37611173)
| - |
Deep-Palm: 0.54
|
|
| 255 | - | - | - |
Deep-Palm: 0.61
|
|
| 287 | - | - | - |
Deep-Palm: 0.77
|
|
| 410 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.84
Deep-Palm: 0.94
|
|
| 493 | - | - | - |
Deep-Palm: 0.17
|
|
| 497 | - | - | - |
Deep-Palm: 0.07
|
|
| 508 | - | - | - |
Deep-Palm: 0.08
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
4
PC3
Specificity: 0.222
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.222
4/4 (100.0%)
3
LNCaP
Specificity: 0.167
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.056
1/1 (100.0%)
1
HeLa cell
Specificity: 0.056
1/1 (100.0%)
1
EC cell
Specificity: 0.056
1/1 (100.0%)
1
293T cell
Specificity: 0.056
1/1 (100.0%)
1
heart
Specificity: 0.056
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.056
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.056
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 75 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 199 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 223 | Y → _I224insYCSWRLQHLSL | 0.002545 | INS | In Frame Ins | GBM |
| 489 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| ? | ? → ? | 0.001887 | SNP | Missense Mutation | UCEC |