Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P08172 CHRM2 Muscarinic acetylcholine receptor M2 Homo sapiens (Human) 466 aa

Protein Details: P08172 (CHRM2)

Protein Information
AccessionP08172
Protein NamesMuscarinic acetylcholine receptor M2
Gene SymbolCHRM2
OrganismHomo sapiens (Human)
Length466 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MNNSTNSSNN11SLALTSPYKT21FEVVFIVLVA31GSLSLVTIIG41NILVMVSIKV
51-10051NRHLQTVNNY61FLFSLACADL71IIGVFSMNLY81TLYTVIGYWP91LGPVVCDLWL
101-150101ALDYVVSNAS111VMNLLIISFD121RYFCVTKPLT131YPVKRTTKMA141GMMIAAAWVL
151-200151SFILWAPAIL161FWQFIVGVRT171VEDGECYIQF181FSNAAVTFGT191AIAAFYLPVI
201-250201IMTVLYWHIS211RASKSRIKKD221KKEPVANQDP231VSPSLVQGRI241VKPNNNNMPS
251-300251SDDGLEHNKI261QNGKAPRDPV271TENCVQGEEK281ESSNDSTSVS291AVASNMRDDE
301-350301ITQDENTVST311SLGHSKDENS321KQTCIRIGTK331TPKSDSCTPT341NTTVEVVGSS
351-400351GQNGDEKQNI361VARKIVKMTK371QPAKKKPPPS381REKKVTRTIL391AILLAFIITW
401-450401APYNVMVLIN411TFCAPCIPNT421VWTIGYWLCY431INSTINPACY441ALCNATFKKT
451-466451FKHLLMCHYK461NIGATR
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
67 - - -
Deep-Palm: 0.11
96 - - -
Deep-Palm: 0.34
124 - - -
GPS-Palm: 0.90
Deep-Palm: 0.45
176 - - -
Deep-Palm: 0.08
274 - - -
Deep-Palm: 0.61
324 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.85
Deep-Palm: 0.62
337 - - -
GPS-Palm: 0.74
Deep-Palm: 0.64
413 - - -
GPS-Palm: 0.82
Deep-Palm: 0.02
416 - - -
Deep-Palm: 0.02
429 - - -
Deep-Palm: 0.02
439 - - -
Deep-Palm: 0.03
443 - - -
Deep-Palm: 0.05
457 DBPTM SWISSPALM - - -
GPS-Palm: 0.91
Deep-Palm: 0.02
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
61 F → C 0.002506 SNP Missense Mutation COAD
67 C → S 0.017544 SNP Missense Mutation UCS
89 W → Cfs*9 0.001887 INS Frame Shift Ins UCEC
96 C → Pfs*10 0.001887 INS Frame Shift Ins UCEC
124 C → F 0.002747 SNP Missense Mutation LIHC
141 G → C 0.002033 SNP Missense Mutation LUSC
148 W → C 0.003559 SNP Missense Mutation KIRP
274 C → S 0.002288 SNP Missense Mutation STAD
282 S → C 0.002294 SNP Missense Mutation OV
413 C → C 0.002033 SNP Silent LUSC
413 C → Lfs*40 0.001887 INS Frame Shift Ins UCEC
429 C → C 0.001887 SNP Silent UCEC
429 C → C 0.005618 SNP Silent PAAD
439 C → S 0.002747 SNP Missense Mutation LIHC
443 C → S 0.002141 SNP Missense Mutation SKCM
416* C → ? 0.001764 SNP Nonsense Mutation LUAD
443* C → ? 0.002427 SNP Nonsense Mutation BLCA