Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta … | Homo sapiens (Human) | 724 aa |
Protein Details: P08238 (HSP90AB1)
Protein Information
| Accession | P08238 |
|---|---|
| Protein Names | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) |
| Gene Symbol | HSP90AB1 |
| Organism | Homo sapiens (Human) |
| Length | 724 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPEEVHHGEE11EVETFAFQAE21IAQLMSLIIN31TFYSNKEIFL41RELISNASDA
51-10051LDKIRYESLT61DPSKLDSGKE71LKIDIIPNPQ81ERTLTLVDTG91IGMTKADLIN
101-150101NLGTIAKSGT111KAFMEALQAG121ADISMIGQFG131VGFYSAYLVA141EKVVVITKHN
151-200151DDEQYAWESS161AGGSFTVRAD171HGEPIGRGTK181VILHLKEDQT191EYLEERRVKE
201-250201VVKKHSQFIG211YPITLYLEKE221REKEISDDEA231EEEKGEKEEE241DKDDEEKPKI
251-300251EDVGSDEEDD261SGKDKKKKTK271KIKEKYIDQE281ELNKTKPIWT291RNPDDITQEE
301-350301YGEFYKSLTN311DWEDHLAVKH321FSVEGQLEFR331ALLFIPRRAP341FDLFENKKKK
351-400351NNIKLYVRRV361FIMDSCDELI371PEYLNFIRGV381VDSEDLPLNI391SREMLQQSKI
401-450401LKVIRKNIVK411KCLELFSELA421EDKENYKKFY431EAFSKNLKLG441IHEDSTNRRR
451-500451LSELLRYHTS461QSGDEMTSLS471EYVSRMKETQ481KSIYYITGES491KEQVANSAFV
501-550501ERVRKRGFEV511VYMTEPIDEY521CVQQLKEFDG531KSLVSVTKEG541LELPEDEEEK
551-600551KKMEESKAKF561ENLCKLMKEI571LDKKVEKVTI581SNRLVSSPCC591IVTSTYGWTA
601-650601NMERIMKAQA611LRDNSTMGYM621MAKKHLEINP631DHPIVETLRQ641KAEADKNDKA
651-700651VKDLVVLLFE661TALLSSGFSL671EDPQTHSNRI681YRMIKLGLGI691DEDEVAAEEP
701-724701NAAVPDEIPP711LEGDEDASRM721EEVD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 366 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.71
Deep-Palm: 0.54
|
|
| 412 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.81
Deep-Palm: 0.96
|
|
| 521 | SWISSPALM DBPTM CYSMODDB | Hsp90 protein |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
Deep-Palm: 0.76
|
| 564 | - |
HeLa
(37611173)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.97
|
|
| 589 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.82
|
|
| 590 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.82
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.235
4
PC3
Specificity: 0.190
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.190
4/4 (100.0%)
3
LNCaP
Specificity: 0.143
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.095
2/2 (100.0%)
1
U937 cell
Specificity: 0.048
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.048
1/1 (100.0%)
1
293T cell
Specificity: 0.048
1/1 (100.0%)
1
heart
Specificity: 0.048
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.190
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 15 | F → Cfs*31 | 0.002020 | DEL | Frame Shift Del | PRAD |
| 56 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 82 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 168 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 405 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 412 | C → Y | 0.001969 | SNP | Missense Mutation | LGG |
| 665 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 682 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |