Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08238 | HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB | Heat shock protein HSP 90-beta … | Homo sapiens (Human) | 724 aa |
Protein Details: P08238 (HSP90AB1)
Protein Information
| Accession | P08238 |
|---|---|
| Protein Names | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) |
| Gene Symbol | HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB |
| Organism | Homo sapiens (Human) |
| Length | 724 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 32944167 33636221 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.545
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.545
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.152
10/10 (100.0%)
6
Jurkat T cells
Specificity: 0.091
6/25 (24.0%)
4
PC3 cells
Specificity: 0.061
4/4 (100.0%)
4
293T cells
Specificity: 0.061
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.061
4/4 (100.0%)
1
U937 cells
Specificity: 0.015
1/1 (100.0%)
1
Liver membrane
Specificity: 0.015
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPEEVHHGEE11EVETFAFQAE21IAQLMSLIIN31TFYSNKEIFL41RELISNASDA
51-10051LDKIRYESLT61DPSKLDSGKE71LKIDIIPNPQ81ERTLTLVDTG91IGMTKADLIN
101-150101NLGTIAKSGT111KAFMEALQAG121ADISMIGQFG131VGFYSAYLVA141EKVVVITKHN
151-200151DDEQYAWESS161AGGSFTVRAD171HGEPIGRGTK181VILHLKEDQT191EYLEERRVKE
201-250201VVKKHSQFIG211YPITLYLEKE221REKEISDDEA231EEEKGEKEEE241DKDDEEKPKI
251-300251EDVGSDEEDD261SGKDKKKKTK271KIKEKYIDQE281ELNKTKPIWT291RNPDDITQEE
301-350301YGEFYKSLTN311DWEDHLAVKH321FSVEGQLEFR331ALLFIPRRAP341FDLFENKKKK
351-400351NNIKLYVRRV361FIMDSCDELI371PEYLNFIRGV381VDSEDLPLNI391SREMLQQSKI
401-450401LKVIRKNIVK411KCLELFSELA421EDKENYKKFY431EAFSKNLKLG441IHEDSTNRRR
451-500451LSELLRYHTS461QSGDEMTSLS471EYVSRMKETQ481KSIYYITGES491KEQVANSAFV
501-550501ERVRKRGFEV511VYMTEPIDEY521CVQQLKEFDG531KSLVSVTKEG541LELPEDEEEK
551-600551KKMEESKAKF561ENLCKLMKEI571LDKKVEKVTI581SNRLVSSPCC591IVTSTYGWTA
601-650601NMERIMKAQA611LRDNSTMGYM621MAKKHLEINP631DHPIVETLRQ641KAEADKNDKA
651-700651VKDLVVLLFE661TALLSSGFSL671EDPQTHSNRI681YRMIKLGLGI691DEDEVAAEEP
701-724701NAAVPDEIPP711LEGDEDASRM721EEVD
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 366 | Prediction (Low) | - | - |
| 412 | Prediction (Medium) | - | - |
| 521 | CYSMODDB SWISSPALM DBPTM | Hsp90 protein | - |
| 564 | Experimental Prediction (Medium) | Hsp90 protein | 37611173 |
| 589 | Prediction (Medium) | - | - |
| 590 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 15 | F → Cfs*31 | 0.002020 | DEL | Frame Shift Del | PRAD |
| 56 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 82 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 168 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 405 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 412 | C → Y | 0.001969 | SNP | Missense Mutation | LGG |
| 665 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 682 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |