Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08574 | CYC1 | Cytochrome c1, heme protein, mitochondrial … | Homo sapiens (Human) | 325 aa |
Protein Details: P08574 (CYC1)
Protein Information
| Accession | P08574 |
|---|---|
| Protein Names | Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) |
| Gene Symbol | CYC1 |
| Organism | Homo sapiens (Human) |
| Length | 325 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 29733200 31251020 31382980 32944167 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAAAASLRG11VVLGPRGAGL21PGARARGLLC31SARPGQLPLR41TPQAVALSSK
51-10051SGLSRGRKVM61LSALGMLAAG71GAGLAMALHS81AVSASDLELH91PPSYPWSHRG
101-150101LLSSLDHTSI111RRGFQVYKQV121CASCHSMDFV131AYRHLVGVCY141TEDEAKELAA
151-200151EVEVQDGPNE161DGEMFMRPGK171LFDYFPKPYP181NSEAARAANN191GALPPDLSYI
201-250201VRARHGGEDY211VFSLLTGYCE221PPTGVSLREG231LYFNPYFPGQ241AIAMAPPIYT
251-300251DVLEFDDGTP261ATMSQIAKDV271CTFLRWASEP281EHDHRKRMGL291KMLMMMALLV
301-325301PLVYTIKRHK311WSVLKSRKLA321YRPPK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 30 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.98
|
|
| 121 | - | - | - |
Deep-Palm: 0.14
|
|
| 124 | - | - | - |
Deep-Palm: 0.26
|
|
| 139 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.90
Deep-Palm: 0.42
|
|
| 219 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.66
Deep-Palm: 0.92
|
|
| 271 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.55
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
2
PC3
Specificity: 0.182
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.091
1/1 (100.0%)
1
U937 cell
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
1
HUVECs
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Cerebral Cortex (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 54 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 121 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 255 | F → C | 0.002288 | SNP | Missense Mutation | STAD |
| 287 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |