Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08581 | MET | Hepatocyte growth factor receptor (HGF … | Homo sapiens (Human) | 1390 aa |
Protein Details: P08581 (MET)
Protein Information
| Accession | P08581 |
|---|---|
| Protein Names | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) |
| Gene Symbol | MET |
| Organism | Homo sapiens (Human) |
| Length | 1390 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKAPAVLAPG11ILVLLFTLVQ21RSNGECKEAL31AKSEMNVNMK41YQLPNFTAET
51-10051PIQNVILHEH61HIFLGATNYI71YVLNEEDLQK81VAEYKTGPVL91EHPDCFPCQD
101-150101CSSKANLSGG111VWKDNINMAL121VVDTYYDDQL131ISCGSVNRGT141CQRHVFPHNH
151-200151TADIQSEVHC161IFSPQIEEPS171QCPDCVVSAL181GAKVLSSVKD191RFINFFVGNT
201-250201INSSYFPDHP211LHSISVRRLK221ETKDGFMFLT231DQSYIDVLPE241FRDSYPIKYV
251-300251HAFESNNFIY261FLTVQRETLD271AQTFHTRIIR281FCSINSGLHS291YMEMPLECIL
301-350301TEKRKKRSTK311KEVFNILQAA321YVSKPGAQLA331RQIGASLNDD341ILFGVFAQSK
351-400351PDSAEPMDRS361AMCAFPIKYV371NDFFNKIVNK381NNVRCLQHFY391GPNHEHCFNR
401-450401TLLRNSSGCE411ARRDEYRTEF421TTALQRVDLF431MGQFSEVLLT441SISTFIKGDL
451-500451TIANLGTSEG461RFMQVVVSRS471GPSTPHVNFL481LDSHPVSPEV491IVEHTLNQNG
501-550501YTLVITGKKI511TKIPLNGLGC521RHFQSCSQCL531SAPPFVQCGW541CHDKCVRSEE
551-600551CLSGTWTQQI561CLPAIYKVFP571NSAPLEGGTR581LTICGWDFGF591RRNNKFDLKK
601-650601TRVLLGNESC611TLTLSESTMN621TLKCTVGPAM631NKHFNMSIII641SNGHGTTQYS
651-700651TFSYVDPVIT661SISPKYGPMA671GGTLLTLTGN681YLNSGNSRHI691SIGGKTCTLK
701-750701SVSNSILECY711TPAQTISTEF721AVKLKIDLAN731RETSIFSYRE741DPIVYEIHPT
751-800751KSFISGGSTI761TGVGKNLNSV771SVPRMVINVH781EAGRNFTVAC791QHRSNSEIIC
801-850801CTTPSLQQLN811LQLPLKTKAF821FMLDGILSKY831FDLIYVHNPV841FKPFEKPVMI
851-900851SMGNENVLEI861KGNDIDPEAV871KGEVLKVGNK881SCENIHLHSE891AVLCTVPNDL
901-950901LKLNSELNIE911WKQAISSTVL921GKVIVQPDQN931FTGLIAGVVS941ISTALLLLLG
951-1000951FFLWLKKRKQ961IKDLGSELVR971YDARVHTPHL981DRLVSARSVS991PTTEMVSNES
1001-10501001VDYRATFPED1011QFPNSSQNGS1021CRQVQYPLTD1031MSPILTSGDS1041DISSPLLQNT
1051-11001051VHIDLSALNP1061ELVQAVQHVV1071IGPSSLIVHF1081NEVIGRGHFG1091CVYHGTLLDN
1101-11501101DGKKIHCAVK1111SLNRITDIGE1121VSQFLTEGII1131MKDFSHPNVL1141SLLGICLRSE
1151-12001151GSPLVVLPYM1161KHGDLRNFIR1171NETHNPTVKD1181LIGFGLQVAK1191GMKYLASKKF
1201-12501201VHRDLAARNC1211MLDEKFTVKV1221ADFGLARDMY1231DKEYYSVHNK1241TGAKLPVKWM
1251-13001251ALESLQTQKF1261TTKSDVWSFG1271VLLWELMTRG1281APPYPDVNTF1291DITVYLLQGR
1301-13501301RLLQPEYCPD1311PLYEVMLKCW1321HPKAEMRPSF1331SELVSRISAI1341FSTFIGEHYV
1351-13901351HVNATYVNVK1361CVAPYPSLLS1371SEDNADDEVD1381TRPASFWETS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 26 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.92
|
|
| 95 | - | - | - |
Deep-Palm: 0.68
|
|
| 98 | - | - | - |
Deep-Palm: 0.21
|
|
| 101 | - | - | - |
Deep-Palm: 0.16
|
|
| 133 | - | - | - |
Deep-Palm: 0.09
|
|
| 141 | - | - | - |
Deep-Palm: 0.04
|
|
| 160 | - | - | - |
Deep-Palm: 0.02
|
|
| 172 | - | - | - |
Deep-Palm: 0.77
|
|
| 175 | - | - | - |
Deep-Palm: 0.93
|
|
| 282 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.37
|
|
| 298 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.90
|
|
| 363 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.36
|
|
| 385 | - | - | - |
Deep-Palm: 0.02
|
|
| 397 | - | - | - |
Deep-Palm: 0.08
|
|
| 409 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.68
|
|
| 520 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.92
|
|
| 526 | - | - | - |
Deep-Palm: 0.06
|
|
| 529 | - | - | - |
Deep-Palm: 0.03
|
|
| 538 | - | - | - |
Deep-Palm: 0.05
|
|
| 541 | - | - | - |
Deep-Palm: 0.06
|
|
| 545 | - | - | - |
Deep-Palm: 0.08
|
|
| 551 | - | - |
Jurkat T
(32651440)
|
Deep-Palm: 0.05
|
|
| 561 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 584 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.55
|
|
| 610 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.94
|
|
| 624 | DBPTM SWISSPALM | IPT/TIG domain | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.14
|
| 697 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.26
|
|
| 709 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.85
|
|
| 790 | - | - | - |
Deep-Palm: 0.20
|
|
| 800 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.63
|
|
| 801 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.54
|
|
| 882 | - | - | - |
Deep-Palm: 0.91
|
|
| 894 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.86
|
| 1021 | - | - | - |
Deep-Palm: 0.13
|
|
| 1091 | - | - | - |
Deep-Palm: 0.34
|
|
| 1107 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.72
|
|
| 1146 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.88
|
|
| 1210 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
|
| 1308 | - | - | - |
Deep-Palm: 0.23
|
|
| 1319 | - | - | - |
Deep-Palm: 0.07
|
|
| 1361 | - | - | - |
Deep-Palm: 0.11
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Jurkat T cells (Mass)
Specificity: 1.000
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 26 | C → R | 0.002545 | SNP | Missense Mutation | GBM |
| 95 | C → F | 0.002427 | SNP | Missense Mutation | BLCA |
| 98 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 172 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 187 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 205 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 228 | F → C | 0.002506 | SNP | Missense Mutation | COAD |
| 396 | H → _C397insSCGLAPSPL | 0.002294 | INS | In Frame Ins | OV |
| 412 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 441 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 697 | C → C | 0.001887 | SNP | Silent | UCEC |
| 800 | C → C | 0.005618 | SNP | Silent | PAAD |
| 882 | C → W | 0.002020 | SNP | Missense Mutation | PRAD |
| 894 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1230 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 1308 | C → S | 0.005435 | SNP | Missense Mutation | ESCA |
| 1319 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 1327 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1356 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1319* | C → ? | 0.002288 | SNP | Nonsense Mutation | STAD |