Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08631-2 | HCK | Tyrosine-protein kinase HCK (EC 2.7.10.2) … | Homo sapiens (Human) | 505 aa |
Protein Details: P08631-2 (HCK)
Protein Information
| Accession | P08631-2 |
|---|---|
| Protein Names | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) |
| Gene Symbol | HCK |
| Organism | Homo sapiens (Human) |
| Length | 505 aa |
| Isoforms | |
| Related PMIDs | 29575903 31251020 36430497 |
| Database Sources | dbPTM |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGCMKSKFLQ11VGGNTFSKTE21TSASPHCPVY31VPDPTSTIKP41GPNSHNSNTP
51-10051GIREAGSEDI61IVVALYDYEA71IHHEDLSFQK81GDQMVVLEES91GEWWKARSLA
101-150101TRKEGYIPSN111YVARVDSLET121EEWFFKGISR131KDAERQLLAP141GNMLGSFMIR
151-200151DSETTKGSYS161LSVRDYDPRQ171GDTVKHYKIR181TLDNGGFYIS191PRSTFSTLQE
201-250201LVDHYKKGND211GLCQKLSVPC221MSSKPQKPWE231KDAWEIPRES241LKLEKKLGAG
251-300251QFGEVWMATY261NKHTKVAVKT271MKPGSMSVEA281FLAEANVMKT291LQHDKLVKLH
301-350301AVVTKEPIYI311ITEFMAKGSL321LDFLKSDEGS331KQPLPKLIDF341SAQIAEGMAF
351-400351IEQRNYIHRD361LRAANILVSA371SLVCKIADFG381LARVIEDNEY391TAREGAKFPI
401-450401KWTAPEAINF411GSFTIKSDVW421SFGILLMEIV431TYGRIPYPGM441SNPEVIRALE
451-500451RGYRMPRPEN461CPEELYNIMM471RCWKNRPEER481PTFEYIQSVL491DDFYTATESQ
501-505501YQQQP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | DBPTM | - | - | - |
GPS-Palm: 0.95
|
| 7 | - | - | - |
Deep-Palm: 0.03
|
|
| 12 | - | - | - |
Deep-Palm: 0.04
|
|
| 24 | - | - | - |
Deep-Palm: 0.92
|
|
| 48 | - | - | - |
Deep-Palm: 0.43
|
|
| 220 | - | - | - |
GPS-Palm: 0.70
|
|
| 234 | - | - | - |
Deep-Palm: 0.74
|
|
| 241 | - | - | - |
Deep-Palm: 0.73
|
|
| 374 | - | - | - |
GPS-Palm: 0.76
|
|
| 395 | - | - | - |
Deep-Palm: 0.94
|
|
| 482 | - | - | - |
Deep-Palm: 0.05
|
|
| 493 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
2
LNCaP
Specificity: 0.286
2/2 (100.0%)
1
HeLa cell
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 377 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 377 | Y → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 411 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 482 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 515 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |