Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P08631-2 | HCK | Isoform 2 of Tyrosine-protein kinase … | Homo sapiens (Human) | 505 aa |
Protein Details: P08631-2 (HCK)
Protein Information
| Accession | P08631-2 |
|---|---|
| Protein Names | Isoform 2 of Tyrosine-protein kinase HCK |
| Gene Symbol | HCK |
| Organism | Homo sapiens (Human) |
| Length | 505 aa |
| Isoforms |
|
| Related PMIDs | 29575903 31251020 |
| Database Sources | dbPTM |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.929
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
13
LNCaP cells
Specificity: 0.929
13/46 (28.3%)
1
HeLa cells
Specificity: 0.071
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGCMKSKFLQ11VGGNTFSKTE21TSASPHCPVY31VPDPTSTIKP41GPNSHNSNTP
51-10051GIREAGSEDI61IVVALYDYEA71IHHEDLSFQK81GDQMVVLEES91GEWWKARSLA
101-150101TRKEGYIPSN111YVARVDSLET121EEWFFKGISR131KDAERQLLAP141GNMLGSFMIR
151-200151DSETTKGSYS161LSVRDYDPRQ171GDTVKHYKIR181TLDNGGFYIS191PRSTFSTLQE
201-250201LVDHYKKGND211GLCQKLSVPC221MSSKPQKPWE231KDAWEIPRES241LKLEKKLGAG
251-300251QFGEVWMATY261NKHTKVAVKT271MKPGSMSVEA281FLAEANVMKT291LQHDKLVKLH
301-350301AVVTKEPIYI311ITEFMAKGSL321LDFLKSDEGS331KQPLPKLIDF341SAQIAEGMAF
351-400351IEQRNYIHRD361LRAANILVSA371SLVCKIADFG381LARVIEDNEY391TAREGAKFPI
401-450401KWTAPEAINF411GSFTIKSDVW421SFGILLMEIV431TYGRIPYPGM441SNPEVIRALE
451-500451RGYRMPRPEN461CPEELYNIMM471RCWKNRPEER481PTFEYIQSVL491DDFYTATESQ
501-505501YQQQP
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 3 | DBPTM Prediction (High) | - | - |
| 220 | Prediction (Low) | - | - |
| 374 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 377 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 377 | Y → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 411 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 482 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 515 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |