Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10301 | RRAS | Ras-related protein R-Ras (EC 3.6.5.2) … | Homo sapiens (Human) | 218 aa |
Protein Details: P10301 (RRAS)
Protein Information
| Accession | P10301 |
|---|---|
| Protein Names | Ras-related protein R-Ras (EC 3.6.5.2) (p23) |
| Gene Symbol | RRAS |
| Organism | Homo sapiens (Human) |
| Length | 218 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 22496122 24357059 26111759 29733200 31251020 32651440 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSGAASGTG11RGRPRGGGPG21PGDPPPSETH31KLVVVGGGGV41GKSALTIQFI
51-10051QSYFVSDYDP61TIEDSYTKIC71SVDGIPARLD81ILDTAGQEEF91GAMREQYMRA
101-150101GHGFLLVFAI111NDRQSFNEVG121KLFTQILRVK131DRDDFPVVLV141GNKADLESQR
151-200151QVPRSEASAF161GASHHVAYFE171ASAKLRLNVD181EAFEQLVRAV191RKYQEQELPP
201-218201SPPSAPRKKG211GGCPCVLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 70 | - | - | - |
Deep-Palm: 0.93
|
|
| 213 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.05
|
| 215 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.276
8
Jurkat T cell
Specificity: 0.267
8/8 (100.0%)
4
LNCaP
Specificity: 0.133
4/4 (100.0%)
4
Primary T cell
Specificity: 0.133
4/4 (100.0%)
4
PC3
Specificity: 0.133
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.133
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.033
1/1 (100.0%)
1
EC cell
Specificity: 0.033
1/1 (100.0%)
1
heart
Specificity: 0.033
1/1 (100.0%)
1
HUVECs
Specificity: 0.033
1/1 (100.0%)
1
DU145 cell
Specificity: 0.033
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.033
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 58 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 150 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 213 | C → C | 0.002506 | SNP | Silent | COAD |