Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10321 | HLA-C | HLA class I histocompatibility antigen, … | Homo sapiens (Human) | 366 aa |
Protein Details: P10321 (HLA-C)
Protein Information
| Accession | P10321 |
|---|---|
| Protein Names | HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C) |
| Gene Symbol | HLA-C |
| Organism | Homo sapiens (Human) |
| Length | 366 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 24357059 25914232 29575903 31251020 32651440 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRVMAPRALL11LLLSGGLALT21ETWACSHSMR31YFDTAVSRPG41RGEPRFISVG
51-10051YVDDTQFVRF61DSDAASPRGE71PRAPWVEQEG81PEYWDRETQK91YKRQAQADRV
101-150101SLRNLRGYYN111QSEDGSHTLQ121RMSGCDLGPD131GRLLRGYDQS141AYDGKDYIAL
151-200151NEDLRSWTAA161DTAAQITQRK171LEAARAAEQL181RAYLEGTCVE191WLRRYLENGK
201-250201ETLQRAEPPK211THVTHHPLSD221HEATLRCWAL231GFYPAEITLT241WQRDGEDQTQ
251-300251DTELVETRPA261GDGTFQKWAA271VVVPSGQEQR281YTCHMQHEGL291QEPLTLSWEP
301-350301SSQPTIPIMG311IVAGLAVLVV321LAVLGAVVTA331MMCRRKSSGG341KGGSCSQAAC
351-366351SNSAQGSDES361LITCKA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 25 | MHC class I-like antigen recognition-like superfamily MHC classes I/II-like antigen recognition protein | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.97
|
|
| 125 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 188 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.98
|
|
| 227 | - | - | - |
Deep-Palm: 0.16
|
|
| 283 | - | - | - |
Deep-Palm: 0.65
|
|
| 333 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 345 | - | - | - |
Deep-Palm: 0.87
|
|
| 350 | - | - | - |
Deep-Palm: 0.80
|
|
| 364 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.286
4
LNCaP
Specificity: 0.267
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.200
3/3 (100.0%)
3
CEM 174 cell
Specificity: 0.200
3/3 (100.0%)
1
HeLa cell
Specificity: 0.067
1/1 (100.0%)
1
EC cell
Specificity: 0.067
1/1 (100.0%)
1
heart
Specificity: 0.067
1/1 (100.0%)
1
HUVECs
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 233 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 283 | C → C | 0.002545 | SNP | Silent | GBM |
| 298 | W → C | 0.002141 | SNP | Missense Mutation | SKCM |