Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P10515 DLAT; DLTA Dihydrolipoyllysine-residue acetyltransferase component of pyruvate … Homo sapiens (Human) 647 aa

Protein Details: P10515 (DLAT)

Protein Information
Accession P10515
Protein Names Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene Symbol DLAT; DLTA
Organism Homo sapiens (Human)
Length 647 aa
Isoforms No isoforms
Related PMIDs 21076176 24357059 29575903 29733200 31251020 32651440 32944167 33636221
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.646
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
42
LNCaP cells
Specificity: 0.646
42/46 (91.3%)
10
HAP1 cells
Specificity: 0.154
10/10 (100.0%)
4
293T cells
Specificity: 0.062
4/10 (40.0%)
3
Jurkat T cells
Specificity: 0.046
3/25 (12.0%)
3
PC3 cells
Specificity: 0.046
3/4 (75.0%)
1
HeLa cells
Specificity: 0.015
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.015
1/2 (50.0%)
1
Liver membrane
Specificity: 0.015
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MWRVCARRAQ11NVAPWAGLEA21RWTALQEVPG31TPRVTSRSGP41APARRNSVTT
51-10051GYGGVRALCG61WTPSSGATPR71NRLLLQLLGS81PGRRYYSLPP91HQKVPLPSLS
101-150101PTMQAGTIAR111WEKKEGDKIN121EGDLIAEVET131DKATVGFESL141EECYMAKILV
151-200151AEGTRDVPIG161AIICITVGKP171EDIEAFKNYT181LDSSAAPTPQ191AAPAPTPAAT
201-250201ASPPTPSAQA211PGSSYPPHMQ221VLLPALSPTM231TMGTVQRWEK241KVGEKLSEGD
251-300251LLAEIETDKA261TIGFEVQEEG271YLAKILVPEG281TRDVPLGTPL291CIIVEKEADI
301-350301SAFADYRPTE311VTDLKPQVPP321PTPPPVAAVP331PTPQPLAPTP341SAPCPATPAG
351-400351PKGRVFVSPL361AKKLAVEKGI371DLTQVKGTGP381DGRITKKDID391SFVPSKVAPA
401-450401PAAVVPPTGP411GMAPVPTGVF421TDIPISNIRR431VIAQRLMQSK441QTIPHYYLSI
451-500451DVNMGEVLLV461RKELNKILEG471RSKISVNDFI481IKASALACLK491VPEANSSWMD
501-550501TVIRQNHVVD511VSVAVSTPAG521LITPIVFNAH531IKGVETIAND541VVSLATKARE
551-600551GKLQPHEFQG561GTFTISNLGM571FGIKNFSAII581NPPQACILAI591GASEDKLVPA
601-647601DNEKGFDVAS611MMSVTLSCDH621RVVDGAVGAQ631WLAEFRKYLE641KPITMLL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
5 Prediction (High) - -
59 Prediction (Low) - -
143 Prediction (Medium) - -
164 Prediction (High) - -
291 Prediction (Medium) - -
488 Prediction (High) - -
586 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
144 Y → C 0.002033 SNP Missense Mutation LUSC
488 C → F 0.001764 SNP Missense Mutation LUAD