Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10515 | DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate … | Homo sapiens (Human) | 647 aa |
Protein Details: P10515 (DLAT)
Protein Information
| Accession | P10515 |
|---|---|
| Protein Names | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) |
| Gene Symbol | DLAT |
| Organism | Homo sapiens (Human) |
| Length | 647 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 29733200 31251020 32651440 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWRVCARRAQ11NVAPWAGLEA21RWTALQEVPG31TPRVTSRSGP41APARRNSVTT
51-10051GYGGVRALCG61WTPSSGATPR71NRLLLQLLGS81PGRRYYSLPP91HQKVPLPSLS
101-150101PTMQAGTIAR111WEKKEGDKIN121EGDLIAEVET131DKATVGFESL141EECYMAKILV
151-200151AEGTRDVPIG161AIICITVGKP171EDIEAFKNYT181LDSSAAPTPQ191AAPAPTPAAT
201-250201ASPPTPSAQA211PGSSYPPHMQ221VLLPALSPTM231TMGTVQRWEK241KVGEKLSEGD
251-300251LLAEIETDKA261TIGFEVQEEG271YLAKILVPEG281TRDVPLGTPL291CIIVEKEADI
301-350301SAFADYRPTE311VTDLKPQVPP321PTPPPVAAVP331PTPQPLAPTP341SAPCPATPAG
351-400351PKGRVFVSPL361AKKLAVEKGI371DLTQVKGTGP381DGRITKKDID391SFVPSKVAPA
401-450401PAAVVPPTGP411GMAPVPTGVF421TDIPISNIRR431VIAQRLMQSK441QTIPHYYLSI
451-500451DVNMGEVLLV461RKELNKILEG471RSKISVNDFI481IKASALACLK491VPEANSSWMD
501-550501TVIRQNHVVD511VSVAVSTPAG521LITPIVFNAH531IKGVETIAND541VVSLATKARE
551-600551GKLQPHEFQG561GTFTISNLGM571FGIKNFSAII581NPPQACILAI591GASEDKLVPA
601-647601DNEKGFDVAS611MMSVTLSCDH621RVVDGAVGAQ631WLAEFRKYLE641KPITMLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.05
|
|
| 59 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
|
| 143 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.91
|
|
| 164 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.96
|
|
| 291 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.97
|
|
| 344 | - | - | - |
Deep-Palm: 0.95
|
|
| 488 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.91
|
|
| 586 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.79
Deep-Palm: 0.95
|
|
| 618 | - | - | - |
Deep-Palm: 0.84
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.286
4
LNCaP
Specificity: 0.211
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.211
4/4 (100.0%)
2
HAP1 cell
Specificity: 0.105
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.053
1/1 (100.0%)
1
293T cell
Specificity: 0.053
1/1 (100.0%)
1
heart
Specificity: 0.053
1/1 (100.0%)
1
HUVECs
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.211
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.053
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 144 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 488 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |