Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10644 | PRKAR1A | cAMP-dependent protein kinase type I-alpha … | Homo sapiens (Human) | 381 aa |
Protein Details: P10644 (PRKAR1A)
Protein Information
| Accession | P10644 |
|---|---|
| Protein Names | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) |
| Gene Symbol | PRKAR1A |
| Organism | Homo sapiens (Human) |
| Length | 381 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 33636221 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MESGSTAASE11EARSLRECEL21YVQKHNIQAL31LKDSIVQLCT41ARPERPMAFL
51-10051REYFERLEKE61EAKQIQNLQK71AGTRTDSRED81EISPPPPNPV91VKGRRRRGAI
101-150101SAEVYTEEDA111ASYVRKVIPK121DYKTMAALAK131AIEKNVLFSH141LDDNERSDIF
151-200151DAMFSVSFIA161GETVIQQGDE171GDNFYVIDQG181ETDVYVNNEW191ATSVGEGGSF
201-250201GELALIYGTP211RAATVKAKTN221VKLWGIDRDS231YRRILMGSTL241RKRKMYEEFL
251-300251SKVSILESLD261KWERLTVADA271LEPVQFEDGQ281KIVVQGEPGD291EFFIILEGSA
301-350301AVLQRRSENE311EFVEVGRLGP321SDYFGEIALL331MNRPRAATVV341ARGPLKCVKL
351-381351DRPRFERVLG361PCSDILKRNI371QQYNSFVSLS381V
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 18 | Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.97
|
|
| 39 | Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.92
|
|
| 347 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.98
|
|
| 362 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
HAP1 cell
Specificity: 0.667
2/2 (100.0%)
1
heart
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 254 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |