Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10768 | ESD | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) … | Homo sapiens (Human) | 282 aa |
Protein Details: P10768 (ESD)
Protein Information
| Accession | P10768 |
|---|---|
| Protein Names | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) |
| Gene Symbol | ESD |
| Organism | Homo sapiens (Human) |
| Length | 282 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MALKQISSNK11CFGGLQKVFE21HDSVELNCKM31KFAVYLPPKA41ETGKCPALYW
51-10051LSGLTCTEQN61FISKSGYHQS71ASEHGLVVIA81PDTSPRGCNI91KGEDESWDFG
101-150101TGAGFYVDAT111EDPWKTNYRM121YSYVTEELPQ131LINANFPVDP141QRMSIFGHSM
151-200151GGHGALICAL161KNPGKYKSVS171AFAPICNPVL181CPWGKKAFSG191YLGTDQSKWK
201-250201AYDATHLVKS211YPGSQLDILI221DQGKDDQFLL231DGQLLPDNFI241AACTEKKIPV
251-282251VFRLQEGYDH261SYYFIATFIT271DHIRHHAKYL281NA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 11 | SWISSPALM DBPTM CYSMODDB | Alpha/Beta hydrolase fold | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.06
|
| 28 | Alpha/Beta hydrolase fold Esterase-like S-formylglutathione hydrolase | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.94
|
|
| 45 | Alpha/Beta hydrolase fold Esterase-like S-formylglutathione hydrolase | - | - |
Deep-Palm: 0.88
|
|
| 56 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.91
|
|
| 88 | - | - | - |
Deep-Palm: 0.90
|
|
| 158 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.70
|
|
| 176 | SWISSPALM DBPTM CYSMODDB | Putative esterase | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.77
|
| 181 | SWISSPALM DBPTM CYSMODDB | Putative esterase | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.82
|
| 243 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.091
1/1 (100.0%)
1
frontal cortex
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 92 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 183 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |