Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P10768 | ESD | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) … | Homo sapiens (Human) | 282 aa |
Protein Details: P10768 (ESD)
Protein Information
| Accession | P10768 |
|---|---|
| Protein Names | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) |
| Gene Symbol | ESD |
| Organism | Homo sapiens (Human) |
| Length | 282 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.526
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
10
HAP1 cells
Specificity: 0.526
10/10 (100.0%)
4
293T cells
Specificity: 0.211
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.211
4/4 (100.0%)
1
Prefrontal cortex
Specificity: 0.053
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MALKQISSNK11CFGGLQKVFE21HDSVELNCKM31KFAVYLPPKA41ETGKCPALYW
51-10051LSGLTCTEQN61FISKSGYHQS71ASEHGLVVIA81PDTSPRGCNI91KGEDESWDFG
101-150101TGAGFYVDAT111EDPWKTNYRM121YSYVTEELPQ131LINANFPVDP141QRMSIFGHSM
151-200151GGHGALICAL161KNPGKYKSVS171AFAPICNPVL181CPWGKKAFSG191YLGTDQSKWK
201-250201AYDATHLVKS211YPGSQLDILI221DQGKDDQFLL231DGQLLPDNFI241AACTEKKIPV
251-282251VFRLQEGYDH261SYYFIATFIT271DHIRHHAKYL281NA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 11 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 56 | Prediction (Low) | - | - |
| 158 | Prediction (Medium) | - | - |
| 176 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Putative esterase | - |
| 181 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Putative esterase | - |
| 243 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 92 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 183 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |