Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P11586 | MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) … | Homo sapiens (Human) | 935 aa |
Protein Details: P11586 (MTHFD1)
Protein Information
| Accession | P11586 |
|---|---|
| Protein Names | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] |
| Gene Symbol | MTHFD1 |
| Organism | Homo sapiens (Human) |
| Length | 935 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPAEILNGK11EISAQIRARL21KNQVTQLKEQ31VPGFTPRLAI41LQVGNRDDSN
51-10051LYINVKLKAA61EEIGIKATHI71KLPRTTTESE81VMKYITSLNE91DSTVHGFLVQ
101-150101LPLDSENSIN111TEEVINAIAP121EKDVDGLTSI131NAGKLARGDL141NDCFIPCTPK
151-200151GCLELIKETG161VPIAGRHAVV171VGRSKIVGAP181MHDLLLWNNA191TVTTCHSKTA
201-250201HLDEEVNKGD211ILVVATGQPE221MVKGEWIKPG231AIVIDCGINY241VPDDKKPNGR
251-300251KVVGDVAYDE261AKERASFITP271VPGGVGPMTV281AMLMQSTVES291AKRFLEKFKP
301-350301GKWMIQYNNL311NLKTPVPSDI321DISRSCKPKP331IGKLAREIGL341LSEEVELYGE
351-400351TKAKVLLSAL361ERLKHRPDGK371YVVVTGITPT381PLGEGKSTTT391IGLVQALGAH
401-450401LYQNVFACVR411QPSQGPTFGI421KGGAAGGGYS431QVIPMEEFNL441HLTGDIHAIT
451-500451AANNLVAAAI461DARIFHELTQ471TDKALFNRLV481PSVNGVRRFS491DIQIRRLKRL
501-550501GIEKTDPTTL511TDEEINRFAR521LDIDPETITW531QRVLDTNDRF541LRKITIGQAP
551-600551TEKGHTRTAQ561FDISVASEIM571AVLALTTSLE581DMRERLGKMV591VASSKKGEPV
601-650601SAEDLGVSGA611LTVLMKDAIK621PNLMQTLEGT631PVFVHAGPFA641NIAHGNSSII
651-700651ADRIALKLVG661PEGFVVTEAG671FGADIGMEKF681FNIKCRYSGL691CPHVVVLVAT
701-750701VRALKMHGGG711PTVTAGLPLP721KAYIQENLEL731VEKGFSNLKK741QIENARMFGI
751-800751PVVVAVNAFK761TDTESELDLI771SRLSREHGAF781DAVKCTHWAE791GGKGALALAQ
801-850801AVQRAAQAPS811SFQLLYDLKL821PVEDKIRIIA831QKIYGADDIE841LLPEAQHKAE
851-900851VYTKQGFGNL861PICMAKTHLS871LSHNPEQKGV881PTGFILPIRD891IRASVGAGFL
901-935901YPLVGTMSTM911PGLPTRPCFY921DIDLDPETEQ931VNGLF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 143 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 147 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 152 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.66
Deep-Palm: 0.93
|
|
| 195 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.54
|
|
| 236 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.95
|
|
| 326 | - | - | - |
Deep-Palm: 0.97
|
|
| 408 | SWISSPALM DBPTM CYSMODDB | Formate--tetrahydrofolate ligase |
HeLa
(29575903)
|
Unknown
(32651440)
|
GPS-Palm: 0.80
Deep-Palm: 0.92
|
| 685 | - | - | - |
Deep-Palm: 0.49
|
|
| 691 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.83
|
|
| 785 | - | - | - |
Deep-Palm: 0.98
|
|
| 863 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 918 | - | - | - |
Deep-Palm: 0.41
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.077
1/1 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 37 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 79 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 87 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 92 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 173 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 371 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 564 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 568 | E → Cfs*24 | 0.001969 | DEL | Frame Shift Del | HNSC |
| 889 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 889 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 892 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |