Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P11586 | MTHFD1; MTHFC; MTHFD | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) … | Homo sapiens (Human) | 935 aa |
Protein Details: P11586 (MTHFD1)
Protein Information
| Accession | P11586 |
|---|---|
| Protein Names | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] |
| Gene Symbol | MTHFD1; MTHFC; MTHFD |
| Organism | Homo sapiens (Human) |
| Length | 935 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29733200 31251020 32944167 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.667
36/46 (78.3%)
6
HAP1 cells
Specificity: 0.111
6/10 (60.0%)
4
PC3 cells
Specificity: 0.074
4/4 (100.0%)
4
293T cells
Specificity: 0.074
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.074
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAPAEILNGK11EISAQIRARL21KNQVTQLKEQ31VPGFTPRLAI41LQVGNRDDSN
51-10051LYINVKLKAA61EEIGIKATHI71KLPRTTTESE81VMKYITSLNE91DSTVHGFLVQ
101-150101LPLDSENSIN111TEEVINAIAP121EKDVDGLTSI131NAGKLARGDL141NDCFIPCTPK
151-200151GCLELIKETG161VPIAGRHAVV171VGRSKIVGAP181MHDLLLWNNA191TVTTCHSKTA
201-250201HLDEEVNKGD211ILVVATGQPE221MVKGEWIKPG231AIVIDCGINY241VPDDKKPNGR
251-300251KVVGDVAYDE261AKERASFITP271VPGGVGPMTV281AMLMQSTVES291AKRFLEKFKP
301-350301GKWMIQYNNL311NLKTPVPSDI321DISRSCKPKP331IGKLAREIGL341LSEEVELYGE
351-400351TKAKVLLSAL361ERLKHRPDGK371YVVVTGITPT381PLGEGKSTTT391IGLVQALGAH
401-450401LYQNVFACVR411QPSQGPTFGI421KGGAAGGGYS431QVIPMEEFNL441HLTGDIHAIT
451-500451AANNLVAAAI461DARIFHELTQ471TDKALFNRLV481PSVNGVRRFS491DIQIRRLKRL
501-550501GIEKTDPTTL511TDEEINRFAR521LDIDPETITW531QRVLDTNDRF541LRKITIGQAP
551-600551TEKGHTRTAQ561FDISVASEIM571AVLALTTSLE581DMRERLGKMV591VASSKKGEPV
601-650601SAEDLGVSGA611LTVLMKDAIK621PNLMQTLEGT631PVFVHAGPFA641NIAHGNSSII
651-700651ADRIALKLVG661PEGFVVTEAG671FGADIGMEKF681FNIKCRYSGL691CPHVVVLVAT
701-750701VRALKMHGGG711PTVTAGLPLP721KAYIQENLEL731VEKGFSNLKK741QIENARMFGI
751-800751PVVVAVNAFK761TDTESELDLI771SRLSREHGAF781DAVKCTHWAE791GGKGALALAQ
801-850801AVQRAAQAPS811SFQLLYDLKL821PVEDKIRIIA831QKIYGADDIE841LLPEAQHKAE
851-900851VYTKQGFGNL861PICMAKTHLS871LSHNPEQKGV881PTGFILPIRD891IRASVGAGFL
901-935901YPLVGTMSTM911PGLPTRPCFY921DIDLDPETEQ931VNGLF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 143 | Prediction (Medium) | - | - |
| 147 | Prediction (High) | - | - |
| 152 | Experimental Prediction (Low) | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain | 37611173 |
| 195 | Experimental Prediction (Medium) | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding domain | 19801377 |
| 236 | Prediction (Medium) | - | - |
| 408 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Formate--tetrahydrofolate ligase | - |
| 863 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 37 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 79 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 87 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 92 | S → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 173 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 371 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 564 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 568 | E → Cfs*24 | 0.001969 | DEL | Frame Shift Del | HNSC |
| 889 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 889 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 892 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |