Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P11717 IGF2R; MPRI Cation-independent mannose-6-phosphate receptor (CI Man-6-P … Homo sapiens (Human) 2491 aa

Protein Details: P11717 (IGF2R)

Protein Information
Accession P11717
Protein Names Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene Symbol IGF2R; MPRI
Organism Homo sapiens (Human)
Length 2491 aa
Isoforms No isoforms
Related PMIDs 19137006 19801377 21076176 26111759 29575903 29733200 31251020 31382980 32944167 33636221 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.586
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
41
LNCaP cells
Specificity: 0.586
41/46 (89.1%)
16
Jurkat T cells
Specificity: 0.229
16/25 (64.0%)
4
PC3 cells
Specificity: 0.057
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.057
4/10 (40.0%)
2
DU145 cells
Specificity: 0.029
2/2 (100.0%)
1
U937 cells
Specificity: 0.014
1/1 (100.0%)
1
HeLa cells
Specificity: 0.014
1/1 (100.0%)
1
Liver membrane
Specificity: 0.014
1/1 (100.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGAAAGRSPH11LGPAPARRPQ21RSLLLLQLLL31LVAAPGSTQA41QAAPFPELCS
51-10051YTWEAVDTKN61NVLYKINICG71SVDIVQCGPS81SAVCMHDLKT91RTYHSVGDSV
101-150101LRSATRSLLE111FNTTVSCDQQ121GTNHRVQSSI131AFLCGKTLGT141PEFVTATECV
151-200151HYFEWRTTAA161CKKDIFKANK171EVPCYVFDEE181LRKHDLNPLI191KLSGAYLVDD
201-250201SDPDTSLFIN211VCRDIDTLRD221PGSQLRACPP231GTAACLVRGH241QAFDVGQPRD
251-300251GLKLVRKDRL261VLSYVREEAG271KLDFCDGHSP281AVTITFVCPS291ERREGTIPKL
301-350301TAKSNCRYEI311EWITEYACHR321DYLESKTCSL331SGEQQDVSID341LTPLAQSGGS
351-400351SYISDGKEYL361FYLNVCGETE371IQFCNKKQAA381VCQVKKSDTS391QVKAAGRYHN
401-450401QTLRYSDGDL411TLIYFGGDEC421SSGFQRMSVI431NFECNKTAGN441DGKGTPVFTG
451-500451EVDCTYFFTW461DTEYACVKEK471EDLLCGATDG481KKRYDLSALV491RHAEPEQNWE
501-550501AVDGSQTETE511KKHFFINICH521RVLQEGKARG531CPEDAAVCAV541DKNGSKNLGK
551-600551FISSPMKEKG561NIQLSYSDGD571DCGHGKKIKT581NITLVCKPGD591LESAPVLRTS
601-650601GEGGCFYEFE611WHTAAACVLS621KTEGENCTVF631DSQAGFSFDL641SPLTKKNGAY
651-700651KVETKKYDFY661INVCGPVSVS671PCQPDSGACQ681VAKSDEKTWN691LGLSNAKLSY
701-750701YDGMIQLNYR711GGTPYNNERH721TPRATLITFL731CDRDAGVGFP741EYQEEDNSTY
751-800751NFRWYTSYAC761PEEPLECVVT771DPSTLEQYDL781SSLAKSEGGL791GGNWYAMDNS
801-850801GEHVTWRKYY811INVCRPLNPV821PGCNRYASAC831QMKYEKDQGS841FTEVVSISNL
851-900851GMAKTGPVVE861DSGSLLLEYV871NGSACTTSDG881RQTTYTTRIH891LVCSRGRLNS
901-950901HPIFSLNWEC911VVSFLWNTEA921ACPIQTTTDT931DQACSIRDPN941SGFVFNLNPL
951-1000951NSSQGYNVSG961IGKIFMFNVC971GTMPVCGTIL981GKPASGCEAE991TQTEELKNWK
1001-10501001PARPVGIEKS1011LQLSTEGFIT1021LTYKGPLSAK1031GTADAFIVRF1041VCNDDVYSGP
1051-11001051LKFLHQDIDS1061GQGIRNTYFE1071FETALACVPS1081PVDCQVTDLA1091GNEYDLTGLS
1101-11501101TVRKPWTAVD1111TSVDGRKRTF1121YLSVCNPLPY1131IPGCQGSAVG1141SCLVSEGNSW
1151-12001151NLGVVQMSPQ1161AAANGSLSIM1171YVNGDKCGNQ1181RFSTRITFEC1191AQISGSPAFQ
1201-12501201LQDGCEYVFI1211WRTVEACPVV1221RVEGDNCEVK1231DPRHGNLYDL1241KPLGLNDTIV
1251-13001251SAGEYTYYFR1261VCGKLSSDVC1271PTSDKSKVVS1281SCQEKREPQG1291FHKVAGLLTQ
1301-13501301KLTYENGLLK1311MNFTGGDTCH1321KVYQRSTAIF1331FYCDRGTQRP1341VFLKETSDCS
1351-14001351YLFEWRTQYA1361CPPFDLTECS1371FKDGAGNSFD1381LSSLSRYSDN1391WEAITGTGDP
1401-14501401EHYLINVCKS1411LAPQAGTEPC1421PPEAAACLLG1431GSKPVNLGRV1441RDGPQWRDGI
1451-15001451IVLKYVDGDL1461CPDGIRKKST1471TIRFTCSESQ1481VNSRPMFISA1491VEDCEYTFAW
1501-15501501PTATACPMKS1511NEHDDCQVTN1521PSTGHLFDLS1531SLSGRAGFTA1541AYSEKGLVYM
1551-16001551SICGENENCP1561PGVGACFGQT1571RISVGKANKR1581LRYVDQVLQL1591VYKDGSPCPS
1601-16501601KSGLSYKSVI1611SFVCRPEARP1621TNRPMLISLD1631KQTCTLFFSW1641HTPLACEQAT
1651-17001651ECSVRNGSSI1661VDLSPLIHRT1671GGYEAYDESE1681DDASDTNPDF1691YINICQPLNP
1701-17501701MHGVPCPAGA1711AVCKVPIDGP1721PIDIGRVAGP1731PILNPIANEI1741YLNFESSTPC
1751-18001751LADKHFNYTS1761LIAFHCKRGV1771SMGTPKLLRT1781SECDFVFEWE1791TPVVCPDEVR
1801-18501801MDGCTLTDEQ1811LLYSFNLSSL1821STSTFKVTRD1831SRTYSVGVCT1841FAVGPEQGGC
1851-19001851KDGGVCLLSG1861TKGASFGRLQ1871SMKLDYRHQD1881EAVVLSYVNG1891DRCPPETDDG
1901-19501901VPCVFPFIFN1911GKSYEECIIE1921SRAKLWCSTT1931ADYDRDHEWG1941FCRHSNSYRT
1951-20001951SSIIFKCDED1961EDIGRPQVFS1971EVRGCDVTFE1981WKTKVVCPPK1991KLECKFVQKH
2001-20502001KTYDLRLLSS2011LTGSWSLVHN2021GVSYYINLCQ2031KIYKGPLGCS2041ERASICRRTT
2051-21002051TGDVQVLGLV2061HTQKLGVIGD2071KVVVTYSKGY2081PCGGNKTASS2091VIELTCTKTV
2101-21502101GRPAFKRFDI2111DSCTYYFSWD2121SRAACAVKPQ2131EVQMVNGTIT2141NPINGKSFSL
2151-22002151GDIYFKLFRA2161SGDMRTNGDN2171YLYEIQLSSI2181TSSRNPACSG2191ANICQVKPND
2201-22502201QHFSRKVGTS2211DKTKYYLQDG2221DLDVVFASSS2231KCGKDKTKSV2241SSTIFFHCDP
2251-23002251LVEDGIPEFS2261HETADCQYLF2271SWYTSAVCPL2281GVGFDSENPG2291DDGQMHKGLS
2301-23502301ERSQAVGAVL2311SLLLVALTCC2321LLALLLYKKE2331RRETVISKLT2341TCCRRSSNVS
2351-24002351YKYSKVNKEE2361ETDENETEWL2371MEEIQLPPPR2381QGKEGQENGH2391ITTKSVKALS
2401-24502401SLHGDDQDSE2411DEVLTIPEVK2421VHSGRGAGAE2431SSHPVRNAQS2441NALQEREDDR
2451-24912451VGLVRGEKAR2461KGKSSSAQQK2471TVSSTKLVSF2481HDDSDEDLLH2491I
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
69 Experimental - 37611173
77 Experimental - 37611173
84 Experimental - 37611173
134 Prediction (Medium) - -
161 Prediction (Low) - -
174 Prediction (Medium) - -
228 Prediction (Medium) - -
235 Prediction (Low) - -
288 Prediction (Low) - -
306 Prediction (Medium) - -
382 Prediction (Medium) - -
434 Prediction (Low) - -
466 Prediction (Low) - -
475 Prediction (Medium) - -
519 Prediction (Medium) - -
531 Prediction (Low) - -
586 Prediction (Low) - -
672 Experimental Cation-independent mannose-6-phosphate receptor repeat 37611173
731 Prediction (High) - -
823 Prediction (Low) - -
893 Prediction (Low) - -
922 Prediction (Low) - -
1125 Prediction (Low) - -
1217 Prediction (Low) - -
1270 Prediction (Medium) - -
1282 Prediction (Low) - -
1333 Prediction (Low) - -
1408 Prediction (Medium) - -
1420 Experimental Cation-independent mannose-6-phosphate receptor repeat 37611173
1461 Prediction (Low) - -
1766 Prediction (Low) - -
1783 Prediction (Low) - -
1917 Prediction (Medium) - -
1927 Prediction (Medium) - -
1975 Prediction (Low) - -
1987 Prediction (Medium) - -
1994 Prediction (Medium) - -
2039 Prediction (Medium) - -
2046 Prediction (Low) - -
2082 Prediction (Medium) - -
2096 Prediction (Medium) - -
2188 Prediction (Low) - -
2232 Prediction (Medium) - -
2319 Prediction (High) - -
2320 Prediction (High) - -
2342 CYSMODDB SWISSPALM DBPTM Prediction (High) - -
2343 CYSMODDB SWISSPALM DBPTM Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
99 S → C 0.001764 SNP Missense Mutation LUAD
99 S → C 0.002427 SNP Missense Mutation BLCA
117 C → S 0.001764 SNP Missense Mutation LUAD
134 C → R 0.002427 SNP Missense Mutation BLCA
235 C → Y 0.002294 SNP Missense Mutation OV
306 C → C 0.001969 SNP Silent LGG
318 C → S 0.002033 SNP Missense Mutation LUSC
352 Y → C 0.001969 SNP Missense Mutation HNSC
432 F → C 0.001764 SNP Missense Mutation LUAD
605 C → S 0.003559 SNP Missense Mutation KIRP
738 G → C 0.001764 SNP Missense Mutation LUAD
742 Y → C 0.002747 SNP Missense Mutation LIHC
767 C → Y 0.001887 SNP Missense Mutation UCEC
910 C → R 0.002141 SNP Missense Mutation SKCM
1217 C → F 0.002288 SNP Missense Mutation STAD
1244 G → C 0.002545 SNP Missense Mutation GBM
1319 C → C 0.002141 SNP Silent SKCM
1325 R → C 0.002506 SNP Missense Mutation COAD
1371 F → C 0.007299 SNP Missense Mutation READ
1403 Y → C 0.001887 SNP Missense Mutation UCEC
1446 W → C 0.002427 SNP Missense Mutation BLCA
1461 C → Y 0.002033 SNP Missense Mutation LUSC
1542 Y → C 0.005618 SNP Missense Mutation PAAD
1559 C → C 0.002288 SNP Silent STAD
1614 C → Y 0.001887 SNP Missense Mutation UCEC
1652 C → G 0.002141 SNP Missense Mutation SKCM
1652 C → Y 0.005435 SNP Missense Mutation ESCA
1669 R → C 0.002033 SNP Missense Mutation LUSC
1766 C → C 0.001969 SNP Silent LGG
1781 S → C 0.001764 SNP Missense Mutation LUAD
1892 R → C 0.002141 SNP Missense Mutation SKCM
1903 C → C 0.002288 SNP Silent STAD
1933 Y → C 0.002545 SNP Missense Mutation GBM
1987 C → C 0.002141 SNP Silent SKCM
2080 Y → C 0.002506 SNP Missense Mutation COAD
2232 C → R 0.002033 SNP Missense Mutation LUSC
2347 S → C 0.002033 SNP Missense Mutation LUSC
2431 S → C 0.001969 SNP Missense Mutation HNSC