Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P11766 ADH5; ADHX; FDH Alcohol dehydrogenase class-3 (EC 1.1.1.1) … Homo sapiens (Human) 374 aa

Protein Details: P11766 (ADH5)

Protein Information
Accession P11766
Protein Names Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)
Gene Symbol ADH5; ADHX; FDH
Organism Homo sapiens (Human)
Length 374 aa
Isoforms No isoforms
Related PMIDs 29733200 31382980 32944167 33636221 36430497 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
HAP1 cells
Specificity: 0.250
4/10 (40.0%)
4
293T cells
Specificity: 0.250
4/10 (40.0%)
3
PC3 cells
Specificity: 0.188
3/4 (75.0%)
3
Cerebral cortex
Specificity: 0.188
3/4 (75.0%)
1
U937 cells
Specificity: 0.062
1/1 (100.0%)
1
Liver membrane
Specificity: 0.062
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MANEVIKCKA11AVAWEAGKPL21SIEEIEVAPP31KAHEVRIKII41ATAVCHTDAY
51-10051TLSGADPEGC61FPVILGHEGA71GIVESVGEGV81TKLKAGDTVI91PLYIPQCGEC
101-150101KFCLNPKTNL111CQKIRVTQGK121GLMPDGTSRF131TCKGKTILHY141MGTSTFSEYT
151-200151VVADISVAKI161DPLAPLDKVC171LLGCGISTGY181GAAVNTAKLE191PGSVCAVFGL
201-250201GGVGLAVIMG211CKVAGASRII221GVDINKDKFA231RAKEFGATEC241INPQDFSKPI
251-300251QEVLIEMTDG261GVDYSFECIG271NVKVMRAALE281ACHKGWGVSV291VVGVAASGEE
301-350301IATRPFQLVT311GRTWKGTAFG321GWKSVESVPK331LVSEYMSKKI341KVDEFVTHNL
351-374351SFDEINKAFE361LMHSGKSIRT371VVKI
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
8 Prediction (Medium) - -
45 Prediction (Low) - -
97 CYSMODDB SWISSPALM DBPTM Alcohol dehydrogenase GroES-like domain -
100 CYSMODDB SWISSPALM DBPTM Prediction (Low) Alcohol dehydrogenase GroES-like domain -
103 CYSMODDB SWISSPALM DBPTM - -
111 Prediction (High) - -
132 Prediction (Low) - -
170 Prediction (Medium) - -
174 Prediction (Medium) - -
195 Experimental - 37611173
211 Experimental Prediction (High) Zinc-binding dehydrogenase 37611173
240 Prediction (Low) - -
268 Prediction (Low) - -
282 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
174 C → Y 0.002506 SNP Missense Mutation COAD
174 C → F 0.002294 SNP Missense Mutation OV
312 R → C 0.001887 SNP Missense Mutation UCEC