Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P11766 | ADH5 | Alcohol dehydrogenase class-3 (EC 1.1.1.1) … | Homo sapiens (Human) | 374 aa |
Protein Details: P11766 (ADH5)
Protein Information
| Accession | P11766 |
|---|---|
| Protein Names | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) |
| Gene Symbol | ADH5 |
| Organism | Homo sapiens (Human) |
| Length | 374 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31382980 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MANEVIKCKA11AVAWEAGKPL21SIEEIEVAPP31KAHEVRIKII41ATAVCHTDAY
51-10051TLSGADPEGC61FPVILGHEGA71GIVESVGEGV81TKLKAGDTVI91PLYIPQCGEC
101-150101KFCLNPKTNL111CQKIRVTQGK121GLMPDGTSRF131TCKGKTILHY141MGTSTFSEYT
151-200151VVADISVAKI161DPLAPLDKVC171LLGCGISTGY181GAAVNTAKLE191PGSVCAVFGL
201-250201GGVGLAVIMG211CKVAGASRII221GVDINKDKFA231RAKEFGATEC241INPQDFSKPI
251-300251QEVLIEMTDG261GVDYSFECIG271NVKVMRAALE281ACHKGWGVSV291VVGVAASGEE
301-350301IATRPFQLVT311GRTWKGTAFG321GWKSVESVPK331LVSEYMSKKI341KVDEFVTHNL
351-374351SFDEINKAFE361LMHSGKSIRT371VVKI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | GroES-like superfamily | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.09
|
|
| 45 | Alcohol dehydrogenase-like, N-terminal ALCOHOL DEHYDROGENASE GroES-like superfamily | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.86
|
|
| 60 | - | - | - |
Deep-Palm: 0.80
|
|
| 97 | SWISSPALM DBPTM CYSMODDB | Alcohol dehydrogenase GroES-like domain | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.94
|
| 100 | SWISSPALM DBPTM CYSMODDB | Alcohol dehydrogenase GroES-like domain | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.53
|
| 103 | SWISSPALM DBPTM CYSMODDB | - | - | - |
Deep-Palm: 0.30
|
| 111 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.60
|
|
| 132 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.70
|
|
| 170 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 174 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.98
|
|
| 195 | - |
HeLa
(37611173)
|
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 211 | - |
HeLa
(37611173)
|
Unknown
(32651440)
|
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 240 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.92
|
|
| 268 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.86
|
|
| 282 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
cerebral cortex
Specificity: 0.300
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.100
1/1 (100.0%)
1
U937 cell
Specificity: 0.100
1/1 (100.0%)
1
293T cell
Specificity: 0.100
1/1 (100.0%)
1
heart
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.300
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 174 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 174 | C → F | 0.002294 | SNP | Missense Mutation | OV |
| 312 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |