Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P12004 | PCNA | DNA sliding clamp PCNA (Cyclin) … | Homo sapiens (Human) | 261 aa |
Protein Details: P12004 (PCNA)
Protein Information
| Accession | P12004 |
|---|---|
| Protein Names | DNA sliding clamp PCNA (Cyclin) (Proliferating cell nuclear antigen) (PCNA) |
| Gene Symbol | PCNA |
| Organism | Homo sapiens (Human) |
| Length | 261 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFEARLVQGS11ILKKVLEALK21DLINEACWDI31SSSGVNLQSM41DSSHVSLVQL
51-10051TLRSEGFDTY61RCDRNLAMGV71NLTSMSKILK81CAGNEDIITL91RAEDNADTLA
101-150101LVFEAPNQEK111VSDYEMKLMD121LDVEQLGIPE131QEYSCVVKMP141SGEFARICRD
151-200151LSHIGDAVVI161SCAKDGVKFS171ASGELGNGNI181KLSQTSNVDK191EEEAVTIEMN
201-250201EPVQLTFALR211YLNFFTKATP221LSSTVTLSMS231ADVPLVVEYK241IADMGHLKYY
251-261251LAPKIEDEEG261S
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 27 | Proliferating cell nuclear antigen, PCNA, N-terminal DNA Polymerase III, subunit A, domain 2 Proliferating cell nuclear antigen, PCNA DNA clamp superfamily | - |
Unknown
(32651440)
|
Deep-Palm: 0.95
|
|
| 62 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.82
|
|
| 81 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.75
Deep-Palm: 0.94
|
|
| 135 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.81
|
|
| 148 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.64
|
|
| 162 | SWISSPALM DBPTM CYSMODDB | Proliferating cell nuclear antigen C-terminal domain |
SW480 cell line
(26865113)
|
Unknown
(32651440)
|
GPS-Palm: 0.84
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
LNCaP
Specificity: 0.429
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.286
2/2 (100.0%)
1
U937 cell
Specificity: 0.143
1/1 (100.0%)
1
293T cell
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 162 | C → Y | 0.002033 | SNP | Missense Mutation | LUSC |
| 215 | F → C | 0.002427 | SNP | Missense Mutation | BLCA |