Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P12004 | PCNA | Proliferating cell nuclear antigen (PCNA) … | Homo sapiens (Human) | 261 aa |
Protein Details: P12004 (PCNA)
Protein Information
| Accession | P12004 |
|---|---|
| Protein Names | Proliferating cell nuclear antigen (PCNA) (Cyclin) |
| Gene Symbol | PCNA |
| Organism | Homo sapiens (Human) |
| Length | 261 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.542
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.542
26/46 (56.5%)
10
HAP1 cells
Specificity: 0.208
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.083
4/25 (16.0%)
4
293T cells
Specificity: 0.083
4/10 (40.0%)
3
PC3 cells
Specificity: 0.062
3/4 (75.0%)
1
U937 cells
Specificity: 0.021
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MFEARLVQGS11ILKKVLEALK21DLINEACWDI31SSSGVNLQSM41DSSHVSLVQL
51-10051TLRSEGFDTY61RCDRNLAMGV71NLTSMSKILK81CAGNEDIITL91RAEDNADTLA
101-150101LVFEAPNQEK111VSDYEMKLMD121LDVEQLGIPE131QEYSCVVKMP141SGEFARICRD
151-200151LSHIGDAVVI161SCAKDGVKFS171ASGELGNGNI181KLSQTSNVDK191EEEAVTIEMN
201-250201EPVQLTFALR211YLNFFTKATP221LSSTVTLSMS231ADVPLVVEYK241IADMGHLKYY
251-261251LAPKIEDEEG261S
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 62 | Prediction (Low) | - | - |
| 81 | Prediction (Low) | - | - |
| 148 | Prediction (Low) | - | - |
| 162 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Proliferating cell nuclear antigen C-terminal domain | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 162 | C → Y | 0.002033 | SNP | Missense Mutation | LUSC |
| 215 | F → C | 0.002427 | SNP | Missense Mutation | BLCA |