Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P12235 | SLC25A4 | ADP/ATP translocase 1 (ADP,ATP carrier … | Homo sapiens (Human) | 298 aa |
Protein Details: P12235 (SLC25A4)
Protein Information
| Accession | P12235 |
|---|---|
| Protein Names | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) |
| Gene Symbol | SLC25A4 |
| Organism | Homo sapiens (Human) |
| Length | 298 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGDHAWSFLK11DFLAGGVAAA21VSKTAVAPIE31RVKLLLQVQH41ASKQISAEKQ
51-10051YKGIIDCVVR61IPKEQGFLSF71WRGNLANVIR81YFPTQALNFA91FKDKYKQLFL
101-150101GGVDRHKQFW111RYFAGNLASG121GAAGATSLCF131VYPLDFARTR141LAADVGKGAA
151-200151QREFHGLGDC161IIKIFKSDGL171RGLYQGFNVS181VQGIIIYRAA191YFGVYDTAKG
201-250201MLPDPKNVHI211FVSWMIAQSV221TAVAGLVSYP231FDTVRRRMMM241QSGRKGADIM
251-298251YTGTVDCWRK261IAKDEGAKAF271FKGAWSNVLR281GMGGAFVLVL291YDEIKKYV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 57 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.97
|
|
| 129 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 160 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.98
|
|
| 257 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.267
4
cerebral cortex
Specificity: 0.211
4/4 (100.0%)
3
PC3
Specificity: 0.158
3/3 (100.0%)
2
LNCaP
Specificity: 0.105
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.105
2/2 (100.0%)
2
293T cell
Specificity: 0.105
2/2 (100.0%)
1
Jurkat T cell
Specificity: 0.053
1/1 (100.0%)
1
heart
Specificity: 0.053
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
Cerebral Cortex (Mass)
Specificity: 0.158
3/4 (75.0%)
1
LNCaP cells (Mass)
Specificity: 0.053
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 16 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 71 | W → C | 0.002294 | SNP | Missense Mutation | OV |
| 80 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 80 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 235 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 129* | C → ? | 0.002506 | SNP | Nonsense Mutation | COAD |