Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P12268 | IMPDH2 | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase … | Homo sapiens (Human) | 514 aa |
Protein Details: P12268 (IMPDH2)
Protein Information
| Accession | P12268 |
|---|---|
| Protein Names | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) |
| Gene Symbol | IMPDH2 |
| Organism | Homo sapiens (Human) |
| Length | 514 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MADYLISGGT11SYVPDDGLTA21QQLFNCGDGL31TYNDFLILPG41YIDFTADQVD
51-10051LTSALTKKIT61LKTPLVSSPM71DTVTEAGMAI81AMALTGGIGF91IHHNCTPEFQ
101-150101ANEVRKVKKY111EQGFITDPVV121LSPKDRVRDV131FEAKARHGFC141GIPITDTGRM
151-200151GSRLVGIISS161RDIDFLKEEE171HDCFLEEIMT181KREDLVVAPA191GITLKEANEI
201-250201LQRSKKGKLP211IVNEDDELVA221IIARTDLKKN231RDYPLASKDA241KKQLLCGAAI
251-300251GTHEDDKYRL261DLLAQAGVDV271VVLDSSQGNS281IFQINMIKYI291KDKYPNLQVI
301-350301GGNVVTAAQA311KNLIDAGVDA321LRVGMGSGSI331CITQEVLACG341RPQATAVYKV
351-400351SEYARRFGVP361VIADGGIQNV371GHIAKALALG381ASTVMMGSLL391AATTEAPGEY
401-450401FFSDGIRLKK411YRGMGSLDAM421DKHLSSQNRY431FSEADKIKVA441QGVSGAVQDK
451-500451GSIHKFVPYL461IAGIQHSCQD471IGAKSLTQVR481AMMYSGELKF491EKRTSSAQVE
501-514501GGVHSLHSYE511KRLF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 26 | Aldolase-type TIM barrel Inosine-5'-monophosphate dehydrogenase | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.49
|
|
| 95 | - | - | - |
Deep-Palm: 0.21
|
|
| 140 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.86
|
|
| 173 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.89
|
|
| 246 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.96
|
|
| 331 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 339 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.90
|
|
| 468 | SWISSPALM DBPTM CYSMODDB | IMP dehydrogenase / GMP reductase domain | - | - |
Deep-Palm: 0.68
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
2
LNCaP
Specificity: 0.400
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.400
2/2 (100.0%)
1
293T cell
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 140 | C → C | 0.002506 | SNP | Silent | COAD |
| 140 | C → S | 0.001969 | SNP | Missense Mutation | LGG |
| 203 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 280 | S → C | 0.002033 | SNP | Missense Mutation | THCA |
| 331 | C → S | 0.002427 | SNP | Missense Mutation | BLCA |
| 388 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 412 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |