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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P12268 IMPDH2; IMPD2 Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase … Homo sapiens (Human) 514 aa

Protein Details: P12268 (IMPDH2)

Protein Information
Accession P12268
Protein Names Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)
Gene Symbol IMPDH2; IMPD2
Organism Homo sapiens (Human)
Length 514 aa
Isoforms No isoforms
Related PMIDs 19137006 29733200 31251020 32944167 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.500
26/46 (56.5%)
10
HAP1 cells
Specificity: 0.192
10/10 (100.0%)
5
Jurkat T cells
Specificity: 0.096
5/25 (20.0%)
4
PC3 cells
Specificity: 0.077
4/4 (100.0%)
4
293T cells
Specificity: 0.077
4/10 (40.0%)
3
Cerebral cortex
Specificity: 0.058
3/4 (75.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MADYLISGGT11SYVPDDGLTA21QQLFNCGDGL31TYNDFLILPG41YIDFTADQVD
51-10051LTSALTKKIT61LKTPLVSSPM71DTVTEAGMAI81AMALTGGIGF91IHHNCTPEFQ
101-150101ANEVRKVKKY111EQGFITDPVV121LSPKDRVRDV131FEAKARHGFC141GIPITDTGRM
151-200151GSRLVGIISS161RDIDFLKEEE171HDCFLEEIMT181KREDLVVAPA191GITLKEANEI
201-250201LQRSKKGKLP211IVNEDDELVA221IIARTDLKKN231RDYPLASKDA241KKQLLCGAAI
251-300251GTHEDDKYRL261DLLAQAGVDV271VVLDSSQGNS281IFQINMIKYI291KDKYPNLQVI
301-350301GGNVVTAAQA311KNLIDAGVDA321LRVGMGSGSI331CITQEVLACG341RPQATAVYKV
351-400351SEYARRFGVP361VIADGGIQNV371GHIAKALALG381ASTVMMGSLL391AATTEAPGEY
401-450401FFSDGIRLKK411YRGMGSLDAM421DKHLSSQNRY431FSEADKIKVA441QGVSGAVQDK
451-500451GSIHKFVPYL461IAGIQHSCQD471IGAKSLTQVR481AMMYSGELKF491EKRTSSAQVE
501-514501GGVHSLHSYE511KRLF
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
26 Prediction (Low) - -
140 Prediction (High) - -
246 Prediction (Medium) - -
331 Prediction (Medium) - -
339 Prediction (Low) - -
468 CYSMODDB SWISSPALM DBPTM IMP dehydrogenase / GMP reductase domain -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
140 C → C 0.002506 SNP Silent COAD
140 C → S 0.001969 SNP Missense Mutation LGG
203 R → C 0.002506 SNP Missense Mutation COAD
280 S → C 0.002033 SNP Missense Mutation THCA
331 C → S 0.002427 SNP Missense Mutation BLCA
388 S → C 0.002427 SNP Missense Mutation BLCA
412 R → C 0.002020 SNP Missense Mutation PRAD