Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P12814-2 ACTN1 Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin … Homo sapiens (Human) 887 aa

Protein Details: P12814-2 (ACTN1)

Protein Information
AccessionP12814-2
Protein NamesAlpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene SymbolACTN1
OrganismHomo sapiens (Human)
Length887 aa
Isoforms
Related PMIDs 31251020
Database SourcesNo database sources
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDHYDSQQTN11DYMQPEEDWD21RDLLLDPAWE31KQQRKTFTAW41CNSHLRKAGT
51-10051QIENIEEDFR61DGLKLMLLLE71VISGERLAKP81ERGKMRVHKI91SNVNKALDFI
101-150101ASKGVKLVSI111GAEEIVDGNV121KMTLGMIWTI131ILRFAIQDIS141VEETSAKEGL
151-200151LLWCQRKTAP161YKNVNIQNFH171ISWKDGLGFC181ALIHRHRPEL191IDYGKLRKDD
201-250201PLTNLNTAFD211VAEKYLDIPK221MLDAEDIVGT231ARPDEKAIMT241YVSSFYHAFS
251-300251GAQKAETAAN261RICKVLAVNQ271ENEQLMEDYE281KLASDLLEWI291RRTIPWLENR
301-350301VPENTMHAMQ311QKLEDFRDYR321RLHKPPKVQE331KCQLEINFNT341LQTKLRLSNR
351-400351PAFMPSEGRM361VSDINNAWGC371LEQVEKGYEE381WLLNEIRRLE391RLDHLAEKFR
401-450401QKASIHEAWT411DGKEAMLRQK421DYETATLSEI431KALLKKHEAF441ESDLAAHQDR
451-500451VEQIAAIAQE461LNELDYYDSP471SVNARCQKIC481DQWDNLGALT491QKRREALERT
501-550501EKLLETIDQL511YLEYAKRAAP521FNNWMEGAME531DLQDTFIVHT541IEEIQGLTTA
551-600551HEQFKATLPD561ADKERLAILG571IHNEVSKIVQ581TYHVNMAGTN591PYTTITPQEI
601-650601NGKWDHVRQL611VPRRDQALTE621EHARQQHNER631LRKQFGAQAN641VIGPWIQTKM
651-700651EEIGRISIEM661HGTLEDQLSH671LRQYEKSIVN681YKPKIDQLEG691DHQLIQEALI
701-750701FDNKHTNYTM711EHIRVGWEQL721LTTIARTINE731VENQILTRDA741KGISQEQMNE
751-800751FRASFNHFDR761KKTGMMDTDD771FRACLISMGY781NMGEAEFARI791MSIVDPNRLG
801-850801VVTFQAFIDF811MSRETADTDT821ADQVMASFKI831LAGDKNYITM841DELRRELPPD
851-887851QAEYCIARMA861PYTGPDSVPG871ALDYMSFSTA881LYGESDL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
41 Calponin homology domain CH domain superfamily - -
Deep-Palm: 0.72
154 -
HeLa (29575903)
-
GPS-Palm: 0.96
Deep-Palm: 0.96
180 - - -
GPS-Palm: 0.91
Deep-Palm: 0.71
263 - - -
Deep-Palm: 0.84
332 - - -
Deep-Palm: 0.88
370 - - -
Deep-Palm: 0.52
476 - - -
Deep-Palm: 0.24
480 - - -
Deep-Palm: 0.42
774 - - -
Deep-Palm: 0.83
860 - - -
Deep-Palm: 0.95
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
41 C → C 0.001887 SNP Silent UCEC
250 S → C 0.002427 SNP Missense Mutation BLCA
321 R → C 0.001887 SNP Missense Mutation UCEC
377 G → C 0.001764 SNP Missense Mutation LUAD
480 C → Y 0.001887 SNP Missense Mutation UCEC
632 R → C 0.001887 SNP Missense Mutation UCEC
714 R → C 0.002506 SNP Missense Mutation COAD
717 W → C 0.001887 SNP Missense Mutation UCEC
803 R → C 0.001887 SNP Missense Mutation UCEC
849 R → C 0.003774 SNP Missense Mutation UCEC
850 R → C 0.002506 SNP Missense Mutation COAD
850 R → C 0.001887 SNP Missense Mutation UCEC