Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P13010 | XRCC5 | DNA repair protein Ku80 (EC … | Homo sapiens (Human) | 732 aa |
Protein Details: P13010 (XRCC5)
Protein Information
| Accession | P13010 |
|---|---|
| Protein Names | DNA repair protein Ku80 (EC 4.2.99.18) (EC 5.6.2.4) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) (X-ray repair cross-complementing protein 5) |
| Gene Symbol | XRCC5 |
| Organism | Homo sapiens (Human) |
| Length | 732 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 26876311 29733200 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVRSGNKAAV11VLCMDVGFTM21SNSIPGIESP31FEQAKKVITM41FVQRQVFAEN
51-10051KDEIALVLFG61TDGTDNPLSG71GDQYQNITVH81RHLMLPDFDL91LEDIESKIQP
101-150101GSQQADFLDA111LIVSMDVIQH121ETIGKKFEKR131HIEIFTDLSS141RFSKSQLDII
151-200151IHSLKKCDIS161LQFFLPFSLG171KEDGSGDRGD181GPFRLGGHGP191SFPLKGITEQ
201-250201QKEGLEIVKM211VMISLEGEDG221LDEIYSFSES231LRKLCVFKKI241ERHSIHWPCR
251-300251LTIGSNLSIR261IAAYKSILQE271RVKKTWTVVD281AKTLKKEDIQ291KETVYCLNDD
301-350301DETEVLKEDI311IQGFRYGSDI321VPFSKVDEEQ331MKYKSEGKCF341SVLGFCKSSQ
351-400351VQRRFFMGNQ361VLKVFAARDD371EAAAVALSSL381IHALDDLDMV391AIVRYAYDKR
401-450401ANPQVGVAFP411HIKHNYECLV421YVQLPFMEDL431RQYMFSSLKN441SKKYAPTEAQ
451-500451LNAVDALIDS461MSLAKKDEKT471DTLEDLFPTT481KIPNPRFQRL491FQCLLHRALH
501-550501PREPLPPIQQ511HIWNMLNPPA521EVTTKSQIPL531SKIKTLFPLI541EAKKKDQVTA
551-600551QEIFQDNHED561GPTAKKLKTE571QGGAHFSVSS581LAEGSVTSVG591SVNPAENFRV
601-650601LVKQKKASFE611EASNQLINHI621EQFLDTNETP631YFMKSIDCIR641AFREEAIKFS
651-700651EEQRFNNFLK661ALQEKVEIKQ671LNHFWEIVVQ681DGITLITKEE691ASGSSVTAEE
701-732701AKKFLAPKDK711PSGDTAAVFE721EGGDVDDLLD731MI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | Ku70/Ku80, N-terminal alpha/beta von Willebrand factor A-like domain superfamily | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.85
|
|
| 157 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.66
Deep-Palm: 0.82
|
|
| 235 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.80
|
|
| 249 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.76
|
|
| 296 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.87
|
|
| 339 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
GPS-Palm: 0.77
Deep-Palm: 0.87
|
|
| 346 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.94
Deep-Palm: 0.71
|
|
| 418 | - | - | - |
Deep-Palm: 0.17
|
|
| 493 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.94
|
|
| 638 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.56
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
cerebral cortex
Specificity: 0.231
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.154
2/2 (100.0%)
1
LNCaP
Specificity: 0.077
1/1 (100.0%)
1
U937 cell
Specificity: 0.077
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.077
1/1 (100.0%)
1
frontal cortex
Specificity: 0.077
1/1 (100.0%)
1
293T cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.231
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 63 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 184 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 296 | C → W | 0.002288 | SNP | Missense Mutation | STAD |
| 316 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 493 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |