Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P13569 CFTR Cystic fibrosis transmembrane conductance regulator … Homo sapiens (Human) 1480 aa

Protein Details: P13569 (CFTR)

Protein Information
AccessionP13569
Protein NamesCystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene SymbolCFTR
OrganismHomo sapiens (Human)
Length1480 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MQRSPLEKAS11VVSKLFFSWT21RPILRKGYRQ31RLELSDIYQI41PSVDSADNLS
51-10051EKLEREWDRE61LASKKNPKLI71NALRRCFFWR81FMFYGIFLYL91GEVTKAVQPL
101-150101LLGRIIASYD111PDNKEERSIA121IYLGIGLCLL131FIVRTLLLHP141AIFGLHHIGM
151-200151QMRIAMFSLI161YKKTLKLSSR171VLDKISIGQL181VSLLSNNLNK191FDEGLALAHF
201-250201VWIAPLQVAL211LMGLIWELLQ221ASAFCGLGFL231IVLALFQAGL241GRMMMKYRDQ
251-300251RAGKISERLV261ITSEMIENIQ271SVKAYCWEEA281MEKMIENLRQ291TELKLTRKAA
301-350301YVRYFNSSAF311FFSGFFVVFL321SVLPYALIKG331IILRKIFTTI341SFCIVLRMAV
351-400351TRQFPWAVQT361WYDSLGAINK371IQDFLQKQEY381KTLEYNLTTT391EVVMENVTAF
401-450401WEEGFGELFE411KAKQNNNNRK421TSNGDDSLFF431SNFSLLGTPV441LKDINFKIER
451-500451GQLLAVAGST461GAGKTSLLMV471IMGELEPSEG481KIKHSGRISF491CSQFSWIMPG
501-550501TIKENIIFGV511SYDEYRYRSV521IKACQLEEDI531SKFAEKDNIV541LGEGGITLSG
551-600551GQRARISLAR561AVYKDADLYL571LDSPFGYLDV581LTEKEIFESC591VCKLMANKTR
601-650601ILVTSKMEHL611KKADKILILH621EGSSYFYGTF631SELQNLQPDF641SSKLMGCDSF
651-700651DQFSAERRNS661ILTETLHRFS671LEGDAPVSWT681ETKKQSFKQT691GEFGEKRKNS
701-750701ILNPINSIRK711FSIVQKTPLQ721MNGIEEDSDE731PLERRLSLVP741DSEQGEAILP
751-800751RISVISTGPT761LQARRRQSVL771NLMTHSVNQG781QNIHRKTTAS791TRKVSLAPQA
801-850801NLTELDIYSR811RLSQETGLEI821SEEINEEDLK831ECFFDDMESI841PAVTTWNTYL
851-900851RYITVHKSLI861FVLIWCLVIF871LAEVAASLVV881LWLLGNTPLQ891DKGNSTHSRN
901-950901NSYAVIITST911SSYYVFYIYV921GVADTLLAMG931FFRGLPLVHT941LITVSKILHH
951-1000951KMLHSVLQAP961MSTLNTLKAG971GILNRFSKDI981AILDDLLPLT991IFDFIQLLLI
1001-10501001VIGAIAVVAV1011LQPYIFVATV1021PVIVAFIMLR1031AYFLQTSQQL1041KQLESEGRSP
1051-11001051IFTHLVTSLK1061GLWTLRAFGR1071QPYFETLFHK1081ALNLHTANWF1091LYLSTLRWFQ
1101-11501101MRIEMIFVIF1111FIAVTFISIL1121TTGEGEGRVG1131IILTLAMNIM1141STLQWAVNSS
1151-12001151IDVDSLMRSV1161SRVFKFIDMP1171TEGKPTKSTK1181PYKNGQLSKV1191MIIENSHVKK
1201-12501201DDIWPSGGQM1211TVKDLTAKYT1221EGGNAILENI1231SFSISPGQRV1241GLLGRTGSGK
1251-13001251STLLSAFLRL1261LNTEGEIQID1271GVSWDSITLQ1281QWRKAFGVIP1291QKVFIFSGTF
1301-13501301RKNLDPYEQW1311SDQEIWKVAD1321EVGLRSVIEQ1331FPGKLDFVLV1341DGGCVLSHGH
1351-14001351KQLMCLARSV1361LSKAKILLLD1371EPSAHLDPVT1381YQIIRRTLKQ1391AFADCTVILC
1401-14501401EHRIEAMLEC1411QQFLVIEENK1421VRQYDSIQKL1431LNERSLFRQA1441ISPSDRVKLF
1451-14801451PHRNSSKCKS1461KPQIAALKEE1471TEEEVQDTRL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
76 - - -
GPS-Palm: 0.85
Deep-Palm: 0.89
128 - - -
GPS-Palm: 0.71
Deep-Palm: 0.96
225 - - -
Deep-Palm: 0.93
276 - - -
Deep-Palm: 0.10
343 - - -
GPS-Palm: 0.96
Deep-Palm: 0.70
491 - - -
Deep-Palm: 0.48
524 DBPTM SWISSPALM - - -
GPS-Palm: 0.87
Deep-Palm: 0.65
590 - - -
GPS-Palm: 0.80
Deep-Palm: 0.91
592 - - -
GPS-Palm: 0.88
Deep-Palm: 0.84
647 - - -
Deep-Palm: 0.82
832 - - -
Deep-Palm: 0.15
866 - - -
Deep-Palm: 0.71
1344 - - -
GPS-Palm: 0.68
Deep-Palm: 0.97
1355 - - -
GPS-Palm: 0.86
Deep-Palm: 0.98
1395 DBPTM SWISSPALM - - -
GPS-Palm: 0.83
Deep-Palm: 0.96
1400 - - -
Deep-Palm: 0.93
1410 - - -
GPS-Palm: 0.69
Deep-Palm: 0.77
1458 - - -
Deep-Palm: 0.91
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
57 W → C 0.001764 SNP Missense Mutation LUAD
109 Y → C 0.002288 SNP Missense Mutation STAD
117 R → C 0.002545 SNP Missense Mutation GBM
316 F → C 0.001887 SNP Missense Mutation UCEC
347 R → C 0.001887 SNP Missense Mutation UCEC
364 S → C 0.002288 SNP Missense Mutation STAD
380 Y → C 0.002427 SNP Missense Mutation BLCA
563 Y → C 0.001887 SNP Missense Mutation UCEC
917 Y → C 0.001887 SNP Missense Mutation UCEC
1066 R → C 0.004283 SNP Missense Mutation SKCM
1089 W → C 0.001764 SNP Missense Mutation LUAD
1107 F → C 0.001887 SNP Missense Mutation UCEC
1297 S → C 0.002288 SNP Missense Mutation STAD
1410 C → C 0.002033 SNP Silent LUSC