Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P13639 | EEF2 | Elongation factor 2 (EF-2) (EC … | Homo sapiens (Human) | 858 aa |
Protein Details: P13639 (EEF2)
Protein Information
| Accession | P13639 |
|---|---|
| Protein Names | Elongation factor 2 (EF-2) (EC 3.6.5.-) |
| Gene Symbol | EEF2 |
| Organism | Homo sapiens (Human) |
| Length | 858 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 22496122 29733200 31251020 31382980 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVNFTVDQIR11AIMDKKANIR21NMSVIAHVDH31GKSTLTDSLV41CKAGIIASAR
51-10051AGETRFTDTR61KDEQERCITI71KSTAISLFYE81LSENDLNFIK91QSKDGAGFLI
101-150101NLIDSPGHVD111FSSEVTAALR121VTDGALVVVD131CVSGVCVQTE141TVLRQAIAER
151-200151IKPVLMMNKM161DRALLELQLE171PEELYQTFQR181IVENVNVIIS191TYGEGESGPM
201-250201GNIMIDPVLG211TVGFGSGLHG221WAFTLKQFAE231MYVAKFAAKG241EGQLGPAERA
251-300251KKVEDMMKKL261WGDRYFDPAN271GKFSKSATSP281EGKKLPRTFC291QLILDPIFKV
301-350301FDAIMNFKKE311ETAKLIEKLD321IKLDSEDKDK331EGKPLLKAVM341RRWLPAGDAL
351-400351LQMITIHLPS361PVTAQKYRCE371LLYEGPPDDE381AAMGIKSCDP391KGPLMMYISK
401-450401MVPTSDKGRF411YAFGRVFSGL421VSTGLKVRIM431GPNYTPGKKE441DLYLKPIQRT
451-500451ILMMGRYVEP461IEDVPCGNIV471GLVGVDQFLV481KTGTITTFEH491AHNMRVMKFS
501-550501VSPVVRVAVE511AKNPADLPKL521VEGLKRLAKS531DPMVQCIIEE541SGEHIIAGAG
551-600551ELHLEICLKD561LEEDHACIPI571KKSDPVVSYR581ETVSEESNVL591CLSKSPNKHN
601-650601RLYMKARPFP611DGLAEDIDKG621EVSARQELKQ631RARYLAEKYE641WDVAEARKIW
651-700651CFGPDGTGPN661ILTDITKGVQ671YLNEIKDSVV681AGFQWATKEG691ALCEENMRGV
701-750701RFDVHDVTLH711ADAIHRGGGQ721IIPTARRCLY731ASVLTAQPRL741MEPIYLVEIQ
751-800751CPEQVVGGIY761GVLNRKRGHV771FEESQVAGTP781MFVVKAYLPV791NESFGFTADL
801-850801RSNTGGQAFP811QCVFDHWQIL821PGDPFDNSSR831PSQVVAETRK841RKGLKEGIPA
851-858851LDNFLDKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 41 | Translational (tr)-type GTP-binding domain P-loop containing nucleoside triphosphate hydrolase TRANSLATION ELONGATION FACTOR-RELATED |
HeLa
(37611173)
|
Unknown
(32651440)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
|
| 67 | - | - | - |
Deep-Palm: 0.74
|
|
| 131 | - | - | - |
Deep-Palm: 0.97
|
|
| 136 | - | - | - |
Deep-Palm: 0.95
|
|
| 290 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(37611173)
|
Unknown
(32651440)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 369 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.79
|
|
| 388 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.71
|
|
| 466 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.96
|
|
| 536 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.96
|
|
| 557 | - | - | - |
Deep-Palm: 0.94
|
|
| 567 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.71
Deep-Palm: 0.76
|
|
| 591 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.88
|
| 651 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.74
|
|
| 693 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.80
|
|
| 728 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 751 | - |
HeLa
(29575903)
|
Unknown
(32651440)
|
Deep-Palm: 0.81
|
|
| 812 | - | - | - |
Deep-Palm: 0.16
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.286
4
cerebral cortex
Specificity: 0.222
4/4 (100.0%)
3
LNCaP
Specificity: 0.167
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.111
2/2 (100.0%)
1
U937 cell
Specificity: 0.056
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.056
1/1 (100.0%)
1
EC cell
Specificity: 0.056
1/1 (100.0%)
1
293T cell
Specificity: 0.056
1/1 (100.0%)
1
heart
Specificity: 0.056
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.222
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 162 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 287 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 397 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 456 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 474 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 580 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 647 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 701 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 728 | C → Wfs*23 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 781 | M → Cfs*20 | 0.001887 | DEL | Frame Shift Del | UCEC |