Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P13639 | EEF2; EF2 | Elongation factor 2 (EF-2) (EC … | Homo sapiens (Human) | 858 aa |
Protein Details: P13639 (EEF2)
Protein Information
| Accession | P13639 |
|---|---|
| Protein Names | Elongation factor 2 (EF-2) (EC 3.6.5.-) |
| Gene Symbol | EEF2; EF2 |
| Organism | Homo sapiens (Human) |
| Length | 858 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 21076176 22496122 29575903 29733200 31251020 31382980 32944167 33636221 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.500
36/46 (78.3%)
11
Jurkat T cells
Specificity: 0.153
11/25 (44.0%)
10
HAP1 cells
Specificity: 0.139
10/10 (100.0%)
4
PC3 cells
Specificity: 0.056
4/4 (100.0%)
4
293T cells
Specificity: 0.056
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.056
4/4 (100.0%)
1
U937 cells
Specificity: 0.014
1/1 (100.0%)
1
Endothelial cells
Specificity: 0.014
1/2 (50.0%)
1
Liver membrane
Specificity: 0.014
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MVNFTVDQIR11AIMDKKANIR21NMSVIAHVDH31GKSTLTDSLV41CKAGIIASAR
51-10051AGETRFTDTR61KDEQERCITI71KSTAISLFYE81LSENDLNFIK91QSKDGAGFLI
101-150101NLIDSPGHVD111FSSEVTAALR121VTDGALVVVD131CVSGVCVQTE141TVLRQAIAER
151-200151IKPVLMMNKM161DRALLELQLE171PEELYQTFQR181IVENVNVIIS191TYGEGESGPM
201-250201GNIMIDPVLG211TVGFGSGLHG221WAFTLKQFAE231MYVAKFAAKG241EGQLGPAERA
251-300251KKVEDMMKKL261WGDRYFDPAN271GKFSKSATSP281EGKKLPRTFC291QLILDPIFKV
301-350301FDAIMNFKKE311ETAKLIEKLD321IKLDSEDKDK331EGKPLLKAVM341RRWLPAGDAL
351-400351LQMITIHLPS361PVTAQKYRCE371LLYEGPPDDE381AAMGIKSCDP391KGPLMMYISK
401-450401MVPTSDKGRF411YAFGRVFSGL421VSTGLKVRIM431GPNYTPGKKE441DLYLKPIQRT
451-500451ILMMGRYVEP461IEDVPCGNIV471GLVGVDQFLV481KTGTITTFEH491AHNMRVMKFS
501-550501VSPVVRVAVE511AKNPADLPKL521VEGLKRLAKS531DPMVQCIIEE541SGEHIIAGAG
551-600551ELHLEICLKD561LEEDHACIPI571KKSDPVVSYR581ETVSEESNVL591CLSKSPNKHN
601-650601RLYMKARPFP611DGLAEDIDKG621EVSARQELKQ631RARYLAEKYE641WDVAEARKIW
651-700651CFGPDGTGPN661ILTDITKGVQ671YLNEIKDSVV681AGFQWATKEG691ALCEENMRGV
701-750701RFDVHDVTLH711ADAIHRGGGQ721IIPTARRCLY731ASVLTAQPRL741MEPIYLVEIQ
751-800751CPEQVVGGIY761GVLNRKRGHV771FEESQVAGTP781MFVVKAYLPV791NESFGFTADL
801-850801RSNTGGQAFP811QCVFDHWQIL821PGDPFDNSSR831PSQVVAETRK841RKGLKEGIPA
851-858851LDNFLDKL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 41 | Experimental Prediction (Medium) | Elongation factor Tu GTP binding domain | 29575903, 37611173 |
| 290 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | 29575903, 37611173 |
| 388 | Prediction (Low) | - | - |
| 536 | Prediction (Low) | - | - |
| 567 | Prediction (Low) | - | - |
| 591 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | 29575903 |
| 651 | Prediction (Medium) | - | - |
| 693 | Prediction (High) | - | - |
| 728 | Experimental Prediction (Medium) | - | 29575903 |
| 751 | Experimental | Elongation factor G C-terminus | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 162 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 287 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 397 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 456 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 474 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 580 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 647 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 701 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 728 | C → Wfs*23 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 781 | M → Cfs*20 | 0.001887 | DEL | Frame Shift Del | UCEC |