Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P13645 KRT10 Keratin, type I cytoskeletal 10 … Homo sapiens (Human) 584 aa

Protein Details: P13645 (KRT10)

Protein Information
AccessionP13645
Protein NamesKeratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)
Gene SymbolKRT10
OrganismHomo sapiens (Human)
Length584 aa
IsoformsNo isoforms
Related PMIDs 25914232 31382980 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MSVRYSSSKH11YSSSRSGGGG21GGGGCGGGGG31VSSLRISSSK41GSLGGGFSSG
51-10051GFSGGSFSRG61SSGGGCFGGS71SGGYGGLGGF81GGGSFRGSYG91SSSFGGSYGG
101-150101IFGGGSFGGG111SFGGGSFGGG121GFGGGGFGGG131FGGGFGGDGG141LLSGNEKVTM
151-200151QNLNDRLASY161LDKVRALEES171NYELEGKIKE181WYEKHGNSHQ191GEPRDYSKYY
201-250201KTIDDLKNQI211LNLTTDNANI221LLQIDNARLA231ADDFRLKYEN241EVALRQSVEA
251-300251DINGLRRVLD261ELTLTKADLE271MQIESLTEEL281AYLKKNHEEE291MKDLRNVSTG
301-350301DVNVEMNAAP311GVDLTQLLNN321MRSQYEQLAE331QNRKDAEAWF341NEKSKELTTE
351-400351IDNNIEQISS361YKSEITELRR371NVQALEIELQ381SQLALKQSLE391ASLAETEGRY
401-450401CVQLSQIQAQ411ISALEEQLQQ421IRAETECQNT431EYQQLLDIKI441RLENEIQTYR
451-500451SLLEGEGSSG461GGGRGGGSFG471GGYGGGSSGG481GSSGGGHGGG491HGGSSGGGYG
501-550501GGSSGGGSSG511GGYGGGSSSG521GHGGSSSGGY531GGGSSGGGGG541GYGGGSSGGG
551-584551SSSGGGYGGG561SSSGGHKSSS571SGSVGESSSK581GPRY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
25 - -
Brain (35358180)
Brain (31311849)
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.83
Deep-Palm: 0.96
66 - -
Brain (35358180)
Brain (31311849)
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.68
Deep-Palm: 0.94
401 - -
Liver (34884899)
Brain (35358180)
Unknown (32651440)
Deep-Palm: 0.97
427 - -
Brain (35358180)
Brain (31311849)
Unknown (32651440)
cerebral cortex (36430497)
Deep-Palm: 0.86
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
PC3
Specificity: 0.333
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.250
3/3 (100.0%)
1
U937 cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
15 R → C 0.002141 SNP Missense Mutation SKCM
44 G → C 0.001887 SNP Missense Mutation UCEC
56 S → C 0.003460 SNP Missense Mutation CESC
83 G → C 0.002545 SNP Missense Mutation GBM
86 R → C 0.002141 SNP Missense Mutation SKCM
94 F → C 0.001887 SNP Missense Mutation UCEC
200 Y → C 0.002506 SNP Missense Mutation COAD
256 R → C 0.005435 SNP Missense Mutation ESCA
399 R → C 0.002020 SNP Missense Mutation PRAD
562 S → C 0.002427 SNP Missense Mutation BLCA
584 Y → C 0.002033 SNP Missense Mutation LUSC