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UniProt ID Gene Symbol Protein Name Organism Length Action
P13945 ADRB3 Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) … Homo sapiens (Human) 408 aa

Protein Details: P13945 (ADRB3)

Protein Information
AccessionP13945
Protein NamesBeta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)
Gene SymbolADRB3
OrganismHomo sapiens (Human)
Length408 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPWPHENSS11LAPWPDLPTL21APNTANTSGL31PGVPWEAALA41GALLALAVLA
51-10051TVGGNLLVIV61AIAWTPRLQT71MTNVFVTSLA81AADLVMGLLV91VPPAATLALT
101-150101GHWPLGATGC111ELWTSVDVLC121VTASIETLCA131LAVDRYLAVT141NPLRYGALVT
151-200151KRCARTAVVL161VWVVSAAVSF171APIMSQWWRV181GADAEAQRCH191SNPRCCAFAS
201-250201NMPYVLLSSS211VSFYLPLLVM221LFVYARVFVV231ATRQLRLLRG241ELGRFPPEES
251-300251PPAPSRSLAP261APVGTCAPPE271GVPACGRRPA281RLLPLREHRA291LCTLGLIMGT
301-350301FTLCWLPFFL311ANVLRALGGP321SLVPGPAFLA331LNWLGYANSA341FNPLIYCRSP
351-400351DFRSAFRRLL361CRCGRRLPPE371PCAAARPALF381PSGVPAARSS391PAQPRLCQRL
401-408401DGASWGVS
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
110 - - -
Deep-Palm: 0.89
120 - - -
Deep-Palm: 0.60
129 - - -
Deep-Palm: 0.89
153 DBPTM SWISSPALM 7 transmembrane receptor (rhodopsin family) - -
GPS-Palm: 0.91
Deep-Palm: 0.97
189 - - -
Deep-Palm: 0.07
195 - - -
Deep-Palm: 0.31
196 - - -
Deep-Palm: 0.32
266 - - -
Deep-Palm: 0.95
275 - - -
GPS-Palm: 0.79
Deep-Palm: 0.98
292 DBPTM SWISSPALM 7 transmembrane receptor (rhodopsin family) - -
GPS-Palm: 0.79
Deep-Palm: 0.89
304 - - -
Deep-Palm: 0.91
347 - - -
GPS-Palm: 0.69
Deep-Palm: 0.38
361 DBPTM SWISSPALM - - -
GPS-Palm: 0.94
Deep-Palm: 0.93
363 DBPTM SWISSPALM - - -
GPS-Palm: 0.88
Deep-Palm: 0.96
372 - - -
GPS-Palm: 0.88
Deep-Palm: 0.96
397 - - -
GPS-Palm: 0.86
Deep-Palm: 0.29
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
110 C → C 0.002506 SNP Silent COAD
110 C → C 0.003460 SNP Silent CESC
113 W → C 0.001887 SNP Missense Mutation UCEC
179 R → C 0.001887 SNP Missense Mutation UCEC
347 C → G 0.001887 SNP Missense Mutation UCEC