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UniProt ID Gene Symbol Protein Name Organism Length Action
P13987 CD59 CD59 glycoprotein (1F5 antigen) (20 … Homo sapiens (Human) 128 aa

Protein Details: P13987 (CD59)

Protein Information
AccessionP13987
Protein NamesCD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)
Gene SymbolCD59
OrganismHomo sapiens (Human)
Length128 aa
IsoformsNo isoforms
Related PMIDs 25914232 29733200
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MGIQGGSVLF11GLLLVLAVFC21HSGHSLQCYN31CPNPTADCKT41AVNCSSDFDA
51-10051CLITKAGLQV61YNKCWKFEHC71NFNDVTTRLR81ENELTYYCCK91KDLCNFNEQL
101-128101ENGGTSLSEK111TVLLLVTPFL121AAAWSLHP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
20 CD59 glycoprotein - -
Deep-Palm: 0.17
28 Snake toxin-like superfamily CD59 glycoprotein - -
Deep-Palm: 0.04
31 Snake toxin-like superfamily CD59 glycoprotein - -
Deep-Palm: 0.02
38 Snake toxin-like superfamily CD59 glycoprotein - -
Deep-Palm: 0.02
44 Snake toxin-like superfamily CD59 glycoprotein - -
Deep-Palm: 0.15
51 Snake toxin-like superfamily - -
GPS-Palm: 0.69
Deep-Palm: 0.24
64 - - -
GPS-Palm: 0.68
Deep-Palm: 0.09
70 SWISSPALM DBPTM CYSMODDB CD59 glycoprotein
HeLa (29575903)
-
Deep-Palm: 0.26
88 SWISSPALM DBPTM CYSMODDB CD59 glycoprotein - -
GPS-Palm: 0.69
Deep-Palm: 0.42
89 SWISSPALM DBPTM CYSMODDB CD59 glycoprotein - -
GPS-Palm: 0.66
Deep-Palm: 0.45
94 - - -
Deep-Palm: 0.28
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
CEM 174 cell
Specificity: 0.750
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine