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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P14416 DRD2 D(2) dopamine receptor (Dopamine D2 … Homo sapiens (Human) 443 aa

Protein Details: P14416 (DRD2)

Protein Information
AccessionP14416
Protein NamesD(2) dopamine receptor (Dopamine D2 receptor)
Gene SymbolDRD2
OrganismHomo sapiens (Human)
Length443 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDPLNLSWYD11DDLERQNWSR21PFNGSDGKAD31RPHYNYYATL41LTLLIAVIVF
51-10051GNVLVCMAVS61REKALQTTTN71YLIVSLAVAD81LLVATLVMPW91VVYLEVVGEW
101-150101KFSRIHCDIF111VTLDVMMCTA121SILNLCAISI131DRYTAVAMPM141LYNTRYSSKR
151-200151RVTVMISIVW161VLSFTISCPL171LFGLNNADQN181ECIIANPAFV191VYSSIVSFYV
201-250201PFIVTLLVYI211KIYIVLRRRR221KRVNTKRSSR231AFRAHLRAPL241KGNCTHPEDM
251-300251KLCTVIMKSN261GSFPVNRRRV271EAARRAQELE281MEMLSSTSPP291ERTRYSPIPP
301-350301SHHQLTLPDP311SHHGLHSTPD321SPAKPEKNGH331AKDHPKIAKI341FEIQTMPNGK
351-400351TRTSLKTMSR361RKLSQQKEKK371ATQMLAIVLG381VFIICWLPFF391ITHILNIHCD
401-443401CNIPPVLYSA411FTWLGYVNSA421VNPIIYTTFN431IEFRKAFLKI441LHC
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
56 - - -
GPS-Palm: 0.90
Deep-Palm: 0.90
107 - - -
Deep-Palm: 0.12
118 - - -
Deep-Palm: 0.05
126 - - -
Deep-Palm: 0.32
168 - - -
Deep-Palm: 0.13
182 - - -
Deep-Palm: 0.24
244 - - -
GPS-Palm: 0.67
Deep-Palm: 0.87
253 - - -
Deep-Palm: 0.17
385 - - -
Deep-Palm: 0.03
399 - - -
Deep-Palm: 0.02
401 - - -
Deep-Palm: 0.02
443 DBPTM SWISSPALM - - -
GPS-Palm: 0.97
Deep-Palm: 0.03
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
34 Y → C 0.001887 SNP Missense Mutation UCEC
56 C → Y 0.001887 SNP Missense Mutation UCEC
107 C → S 0.002033 SNP Missense Mutation LUSC
118 C → R 0.001764 SNP Missense Mutation LUAD
217 R → C 0.002288 SNP Missense Mutation STAD
217 R → C 0.002141 SNP Missense Mutation SKCM
219 R → C 0.002976 SNP Missense Mutation KIRC
253 C → S 0.002294 SNP Missense Mutation OV
346 M → Cfs*13 0.002033 DEL Frame Shift Del LUSC
399 C → S 0.002288 SNP Missense Mutation STAD