Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P14550 | AKR1A1 | Aldo-keto reductase family 1 member … | Homo sapiens (Human) | 325 aa |
Protein Details: P14550 (AKR1A1)
Protein Information
| Accession | P14550 |
|---|---|
| Protein Names | Aldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20) (S-nitroso-CoA reductase) (ScorR) (EC 1.6.-.-) |
| Gene Symbol | AKR1A1 |
| Organism | Homo sapiens (Human) |
| Length | 325 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAASCVLLHT11GQKMPLIGLG21TWKSEPGQVK31AAVKYALSVG41YRHIDCAAIY
51-10051GNEPEIGEAL61KEDVGPGKAV71PREELFVTSK81LWNTKHHPED91VEPALRKTLA
101-150101DLQLEYLDLY111LMHWPYAFER121GDNPFPKNAD131GTICYDSTHY141KETWKALEAL
151-200151VAKGLVQALG161LSNFNSRQID171DILSVASVRP181AVLQVECHPY191LAQNELIAHC
201-250201QARGLEVTAY211SPLGSSDRAW221RDPDEPVLLE231EPVVLALAEK241YGRSPAQILL
251-300251RWQVQRKVIC261IPKSITPSRI271LQNIKVFDFT281FSPEEMKQLN291ALNKNWRYIV
301-325301PMLTVDGKRV311PRDAGHPLYP321FNDPY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.97
Deep-Palm: 0.05
|
|
| 46 | NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily | - | - |
Deep-Palm: 0.90
|
|
| 134 | - | - | - |
Deep-Palm: 0.83
|
|
| 187 | - | - | - |
Deep-Palm: 0.67
|
|
| 200 | - | - | - |
Deep-Palm: 0.90
|
|
| 260 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.89
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
2
LNCaP
Specificity: 0.167
2/2 (100.0%)
1
U937 cell
Specificity: 0.083
1/1 (100.0%)
1
293T cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 211 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |