Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P15121 | AKR1B1 | Aldo-keto reductase family 1 member … | Homo sapiens (Human) | 316 aa |
Protein Details: P15121 (AKR1B1)
Protein Information
| Accession | P15121 |
|---|---|
| Protein Names | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) |
| Gene Symbol | AKR1B1 |
| Organism | Homo sapiens (Human) |
| Length | 316 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASRLLLNNG11AKMPILGLGT21WKSPPGQVTE31AVKVAIDVGY41RHIDCAHVYQ
51-10051NENEVGVAIQ61EKLREQVVKR71EELFIVSKLW81CTYHEKGLVK91GACQKTLSDL
101-150101KLDYLDLYLI111HWPTGFKPGK121EFFPLDESGN131VVPSDTNILD141TWAAMEELVD
151-200151EGLVKAIGIS161NFNHLQVEMI171LNKPGLKYKP181AVNQIECHPY191LTQEKLIQYC
201-250201QSKGIVVTAY211SPLGSPDRPW221AKPEDPSLLE231DPRIKAIAAK241HNKTTAQVLI
251-300251RFPMQRNLVV261IPKSVTPERI271AENFKVFDFE281LSSQDMTTLL291SYNRNWRVCA
301-316301LLSCTSHKDY311PFHEEF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 45 | NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily Aldo-keto reductase | - |
Unknown
(32651440)
|
Deep-Palm: 0.40
|
|
| 81 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.86
|
|
| 93 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.84
|
|
| 187 | - | - | - |
Deep-Palm: 0.52
|
|
| 200 | SWISSPALM DBPTM CYSMODDB | Aldo/keto reductase family | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.77
|
| 299 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.15
|
|
| 304 | - | - | - |
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
1
HAP1 cell
Specificity: 0.083
1/1 (100.0%)
1
frontal cortex
Specificity: 0.083
1/1 (100.0%)
1
293T cell
Specificity: 0.083
1/1 (100.0%)
1
heart
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 104 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 158 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 269 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 279 | F → delinsC*DLKI | 0.001887 | INS | Nonsense Mutation | UCEC |