Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P15121 | AKR1B1; ALDR1; ALR2 | Aldo-keto reductase family 1 member … | Homo sapiens (Human) | 316 aa |
Protein Details: P15121 (AKR1B1)
Protein Information
| Accession | P15121 |
|---|---|
| Protein Names | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) |
| Gene Symbol | AKR1B1; ALDR1; ALR2 |
| Organism | Homo sapiens (Human) |
| Length | 316 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29575903 29733200 33636221 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
6
HAP1 cells
Specificity: 0.375
6/10 (60.0%)
4
293T cells
Specificity: 0.250
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.250
4/4 (100.0%)
1
Prefrontal cortex
Specificity: 0.062
1/1 (100.0%)
1
Liver membrane
Specificity: 0.062
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MASRLLLNNG11AKMPILGLGT21WKSPPGQVTE31AVKVAIDVGY41RHIDCAHVYQ
51-10051NENEVGVAIQ61EKLREQVVKR71EELFIVSKLW81CTYHEKGLVK91GACQKTLSDL
101-150101KLDYLDLYLI111HWPTGFKPGK121EFFPLDESGN131VVPSDTNILD141TWAAMEELVD
151-200151EGLVKAIGIS161NFNHLQVEMI171LNKPGLKYKP181AVNQIECHPY191LTQEKLIQYC
201-250201QSKGIVVTAY211SPLGSPDRPW221AKPEDPSLLE231DPRIKAIAAK241HNKTTAQVLI
251-300251RFPMQRNLVV261IPKSVTPERI271AENFKVFDFE281LSSQDMTTLL291SYNRNWRVCA
301-316301LLSCTSHKDY311PFHEEF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 81 | Prediction (Medium) | - | - |
| 93 | Prediction (Medium) | - | - |
| 200 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) | Aldo/keto reductase family | 29575903 |
| 299 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 104 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 158 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 269 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 279 | F → delinsC*DLKI | 0.001887 | INS | Nonsense Mutation | UCEC |