Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P15153 | RAC2 | Ras-related C3 botulinum toxin substrate … | Homo sapiens (Human) | 192 aa |
Protein Details: P15153 (RAC2)
Protein Information
| Accession | P15153 |
|---|---|
| Protein Names | Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) |
| Gene Symbol | RAC2 |
| Organism | Homo sapiens (Human) |
| Length | 192 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MQAIKCVVVG11DGAVGKTCLL21ISYTTNAFPG31EYIPTVFDNY41SANVMVDSKP
51-10051VNLGLWDTAG61QEDYDRLRPL71SYPQTDVFLI81CFSLVSPASY91ENVRAKWFPE
101-150101VRHHCPSTPI111ILVGTKLDLR121DDKDTIEKLK131EKKLAPITYP141QGLALAKEID
151-192151SVKYLECSAL161TQRGLKTVFD171EAIRAVLCPQ181PTRQQKRACS191LL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 6 | SWISSPALM DBPTM CYSMODDB | Ras family P-loop containing nucleoside triphosphate hydrolase Small GTPase |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.09
|
| 18 | P-loop containing nucleoside triphosphate hydrolase Transforming protein P21 ras signature Small GTPase Small GTPase Rho | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.97
|
|
| 81 | - | - | - |
Deep-Palm: 0.95
|
|
| 105 | - | - | - |
Deep-Palm: 0.97
|
|
| 157 | SWISSPALM DBPTM CYSMODDB | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.91
Deep-Palm: 0.98
|
| 178 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 189 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
LNCaP
Specificity: 0.667
2/2 (100.0%)
1
293T cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 18 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 89 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 189 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |