Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P15170 | GSPT1 | Eukaryotic peptide chain release factor … | Homo sapiens (Human) | 499 aa |
Protein Details: P15170 (GSPT1)
Protein Information
| Accession | P15170 |
|---|---|
| Protein Names | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) |
| Gene Symbol | GSPT1 |
| Organism | Homo sapiens (Human) |
| Length | 499 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MELSEPIVEN11GETEMSPEES21WEHKEEISEA31EPGGGSLGDG41RPPEESAHEM
51-10051MEEEEEIPKP61KSVVAPPGAP71KKEHVNVVFI81GHVDAGKSTI91GGQIMYLTGM
101-150101VDKRTLEKYE111REAKEKNRET121WYLSWALDTN131QEERDKGKTV141EVGRAYFETE
151-200151KKHFTILDAP161GHKSFVPNMI171GGASQADLAV181LVISARKGEF191ETGFEKGGQT
201-250201REHAMLAKTA211GVKHLIVLIN221KMDDPTVNWS231NERYEECKEK241LVPFLKKVGF
251-300251NPKKDIHFMP261CSGLTGANLK271EQSDFCPWYI281GLPFIPYLDN291LPNFNRSVDG
301-350301PIRLPIVDKY311KDMGTVVLGK321LESGSICKGQ331QLVMMPNKHN341VEVLGILSDD
351-400351VETDTVAPGE361NLKIRLKGIE371EEEILPGFIL381CDPNNLCHSG391RTFDAQIVII
401-450401EHKSIICPGY411NAVLHIHTCI421EEVEITALIC431LVDKKSGEKS441KTRPRFVKQD
451-499451QVCIARLRTA461GTICLETFKD471FPQMGRFTLR481DEGKTIAIGK491VLKLVPEKD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 237 | - | - | - |
Deep-Palm: 0.87
|
|
| 261 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.89
|
|
| 276 | - | - | - |
Deep-Palm: 0.88
|
|
| 327 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.96
|
|
| 381 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.87
|
| 387 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.40
|
| 407 | - | - | - |
Deep-Palm: 0.06
|
|
| 419 | - | - | - |
Deep-Palm: 0.11
|
|
| 430 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.81
|
|
| 453 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.85
|
|
| 464 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.92
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
HAP1 cell
Specificity: 0.500
1/1 (100.0%)
1
293T cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 410 | Y → C | 0.002545 | SNP | Missense Mutation | GBM |
| 456 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |