Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P16473 | TSHR | Thyrotropin receptor (Thyroid-stimulating hormone receptor) … | Homo sapiens (Human) | 764 aa |
Protein Details: P16473 (TSHR)
Protein Information
| Accession | P16473 |
|---|---|
| Protein Names | Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) |
| Gene Symbol | TSHR |
| Organism | Homo sapiens (Human) |
| Length | 764 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MRPADLLQLV11LLLDLPRDLG21GMGCSSPPCE31CHQEEDFRVT41CKDIQRIPSL
51-10051PPSTQTLKLI61ETHLRTIPSH71AFSNLPNISR81IYVSIDVTLQ91QLESHSFYNL
101-150101SKVTHIEIRN111TRNLTYIDPD121ALKELPLLKF131LGIFNTGLKM141FPDLTKVYST
151-200151DIFFILEITD161NPYMTSIPVN171AFQGLCNETL181TLKLYNNGFT191SVQGYAFNGT
201-250201KLDAVYLNKN211KYLTVIDKDA221FGGVYSGPSL231LDVSQTSVTA241LPSKGLEHLK
251-300251ELIARNTWTL261KKLPLSLSFL271HLTRADLSYP281SHCCAFKNQK291KIRGILESLM
301-350301CNESSMQSLR311QRKSVNALNS321PLHQEYEENL331GDSIVGYKEK341SKFQDTHNNA
351-400351HYYVFFEEQE361DEIIGFGQEL371KNPQEETLQA381FDSHYDYTIC391GDSEDMVCTP
401-450401KSDEFNPCED411IMGYKFLRIV421VWFVSLLALL431GNVFVLLILL441TSHYKLNVPR
451-500451FLMCNLAFAD461FCMGMYLLLI471ASVDLYTHSE481YYNHAIDWQT491GPGCNTAGFF
501-550501TVFASELSVY511TLTVITLERW521YAITFAMRLD531RKIRLRHACA541IMVGGWVCCF
551-600551LLALLPLVGI561SSYAKVSICL571PMDTETPLAL581AYIVFVLTLN591IVAFVIVCCC
601-650601YVKIYITVRN611PQYNPGDKDT621KIAKRMAVLI631FTDFICMAPI641SFYALSAILN
651-700651KPLITVSNSK661ILLVLFYPLN671SCANPFLYAI681FTKAFQRDVF691ILLSKFGICK
701-750701RQAQAYRGQR711VPPKNSTDIQ721VQKVTHEMRQ731GLHNMEDVYE741LIENSHLTPK
751-764751KQGQISEEYM761QTVL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 24 | Thyrotropin receptor | - | - |
Deep-Palm: 0.97
|
|
| 29 | Thyrotropin receptor | - | - |
Deep-Palm: 0.25
|
|
| 31 | Thyrotropin receptor | - | - |
Deep-Palm: 0.10
|
|
| 41 | Leucine-rich repeat domain superfamily Thyrotropin receptor | - | - |
Deep-Palm: 0.09
|
|
| 176 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.59
|
|
| 283 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.83
|
|
| 284 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.87
|
|
| 301 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.93
|
|
| 390 | - | - | - |
Deep-Palm: 0.08
|
|
| 398 | - | - | - |
Deep-Palm: 0.04
|
|
| 408 | - | - | - |
Deep-Palm: 0.10
|
|
| 454 | - | - | - |
Deep-Palm: 0.26
|
|
| 462 | - | - | - |
Deep-Palm: 0.12
|
|
| 494 | - | - | - |
Deep-Palm: 0.11
|
|
| 539 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.53
|
|
| 548 | - | - | - |
Deep-Palm: 0.84
|
|
| 549 | - | - | - |
Deep-Palm: 0.93
|
|
| 569 | - | - | - |
Deep-Palm: 0.97
|
|
| 598 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.11
|
|
| 599 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.09
|
|
| 600 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.08
|
|
| 636 | - | - | - |
Deep-Palm: 0.23
|
|
| 672 | - | - | - |
Deep-Palm: 0.55
|
|
| 699 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
Jurkat T cells (Mass)
Specificity: 1.000
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 46 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 98 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 176 | C → C | 0.001887 | SNP | Silent | UCEC |
| 221 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 353 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 519 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 699 | C → Y | 0.002033 | SNP | Missense Mutation | LUSC |
| 283* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |
| 598* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |