Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P17516 | AKR1C4 | Aldo-keto reductase family 1 member … | Homo sapiens (Human) | 323 aa |
Protein Details: P17516 (AKR1C4)
Protein Information
| Accession | P17516 |
|---|---|
| Protein Names | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid 3-dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) |
| Gene Symbol | AKR1C4 |
| Organism | Homo sapiens (Human) |
| Length | 323 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDPKYQRVEL11NDGHFMPVLG21FGTYAPPEVP31RNRAVEVTKL41AIEAGFRHID
51-10051SAYLYNNEEQ61VGLAIRSKIA71DGSVKREDIF81YTSKLWCTFF91QPQMVQPALE
101-150101SSLKKLQLDY111VDLYLLHFPM121ALKPGETPLP131KDENGKVIFD141TVDLSATWEV
151-200151MEKCKDAGLA161KSIGVSNFNC171RQLEMILNKP181GLKYKPVCNQ191VECHPYLNQS
201-250201KLLDFCKSKD211IVLVAHSALG221TQRHKLWVDP231NSPVLLEDPV241LCALAKKHKQ
251-300251TPALIALRYQ261LQRGVVVLAK271SYNEQRIREN281IQVFEFQLTS291EDMKVLDGLN
301-323301RNYRYVVMDF311LMDHPDYPFS321DEY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 87 | - | - | - |
Deep-Palm: 0.57
|
|
| 154 | - | - | - |
Deep-Palm: 0.78
|
|
| 170 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.92
|
|
| 188 | - | - | - |
Deep-Palm: 0.63
|
|
| 193 | - | - | - |
Deep-Palm: 0.66
|
|
| 206 | SWISSPALM DBPTM CYSMODDB | Aldo/keto reductase family | - | - |
Deep-Palm: 0.95
|
| 242 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 47 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 258 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 258 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 323 | Y → C | 0.003774 | SNP | Missense Mutation | UCEC |