Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P17661 | DES | Desmin | Homo sapiens (Human) | 470 aa |
Protein Details: P17661 (DES)
Protein Information
| Accession | P17661 |
|---|---|
| Protein Names | Desmin |
| Gene Symbol | DES |
| Organism | Homo sapiens (Human) |
| Length | 470 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSQAYSSSQR11VSSYRRTFGG21APGFPLGSPL31SSPVFPRAGF41GSKGSSSSVT
51-10051SRVYQVSRTS61GGAGGLGSLR71ASRLGTTRTP81SSYGAGELLD91FSLADAVNQE
101-150101FLTTRTNEKV111ELQELNDRFA121NYIEKVRFLE131QQNAALAAEV141NRLKGREPTR
151-200151VAELYEEELR161ELRRQVEVLT171NQRARVDVER181DNLLDDLQRL191KAKLQEEIQL
201-250201KEEAENNLAA211FRADVDAATL221ARIDLERRIE231SLNEEIAFLK241KVHEEEIREL
251-300251QAQLQEQQVQ261VEMDMSKPDL271TAALRDIRAQ281YETIAAKNIS291EAEEWYKSKV
301-350301SDLTQAANKN311NDALRQAKQE321MMEYRHQIQS331YTCEIDALKG341TNDSLMRQMR
351-400351ELEDRFASEA361SGYQDNIARL371EEEIRHLKDE381MARHLREYQD391LLNVKMALDV
401-450401EIATYRKLLE411GEESRINLPI421QTYSALNFRE431TSPEQRGSEV441HTKKTVMIKT
451-470451IETRDGEVVS461EATQQQHEVL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 333 | - | - | - |
Deep-Palm: 0.08
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
cerebral cortex
Specificity: 0.800
4/4 (100.0%)
1
HUVECs
Specificity: 0.200
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 222 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 315 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 369 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 386 | R → C | 0.002545 | SNP | Missense Mutation | GBM |