Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P17812 | CTPS1 | CTP synthase 1 (EC 6.3.4.2) … | Homo sapiens (Human) | 591 aa |
Protein Details: P17812 (CTPS1)
Protein Information
| Accession | P17812 |
|---|---|
| Protein Names | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (Protein-asparagine deamidase CTPS1) (EC 3.5.1.-) (UTP--ammonia ligase 1) |
| Gene Symbol | CTPS1 |
| Organism | Homo sapiens (Human) |
| Length | 591 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKYILVTGGV11ISGIGKGIIA21SSVGTILKSC31GLHVTSIKID41PYINIDAGTF
51-10051SPYEHGEVFV61LDDGGEVDLD71LGNYERFLDI81RLTKDNNLTT91GKIYQYVINK
101-150101ERKGDYLGKT111VQVVPHITDA121IQEWVMRQAL131IPVDEDGLEP141QVCVIELGGT
151-200151VGDIESMPFI161EAFRQFQFKV171KRENFCNIHV181SLVPQPSSTG191EQKTKPTQNS
201-250201VRELRGLGLS211PDLVVCRCSN221PLDTSVKEKI231SMFCHVEPEQ241VICVHDVSSI
251-300251YRVPLLLEEQ261GVVDYFLRRL271DLPIERQPRK281MLMKWKEMAD291RYDRLLETCS
301-350301IALVGKYTKF311SDSYASVIKA321LEHSALAINH331KLEIKYIDSA341DLEPITSQEE
351-400351PVRYHEAWQK361LCSAHGVLVP371GGFGVRGTEG381KIQAIAWARN391QKKPFLGVCL
401-450401GMQLAVVEFS411RNVLGWQDAN421STEFDPTTSH431PVVVDMPEHN441PGQMGGTMRL
451-500451GKRRTLFQTK461NSVMRKLYGD471ADYLEERHRH481RFEVNPVWKK491CLEEQGLKFV
501-550501GQDVEGERME511IVELEDHPFF521VGVQYHPEFL531SRPIKPSPPY541FGLLLASVGR
551-591551LSHYLQKGCR561LSPRDTYSDR571SGSSSPDSEI581TELKFPSINH591D
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 30 | CTP synthase CTP synthase, N-terminal P-loop containing nucleoside triphosphate hydrolase | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.97
|
|
| 143 | - | - | - |
Deep-Palm: 0.93
|
|
| 176 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.52
|
|
| 216 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 218 | - | - | - |
Deep-Palm: 0.97
|
|
| 234 | - | - | - |
Deep-Palm: 0.24
|
|
| 243 | - | - | - |
Deep-Palm: 0.46
|
|
| 299 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.86
|
|
| 362 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.76
Deep-Palm: 0.96
|
|
| 399 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.95
|
|
| 491 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.94
|
|
| 559 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
2
PC3
Specificity: 0.333
2/2 (100.0%)
1
293T cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 164 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 294 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 294 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 299 | C → C | 0.002033 | SNP | Silent | LUSC |
| 300 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |