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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P17813 ENG Endoglin (CD antigen CD105) Homo sapiens (Human) 658 aa

Protein Details: P17813 (ENG)

Protein Information
AccessionP17813
Protein NamesEndoglin (CD antigen CD105)
Gene SymbolENG
OrganismHomo sapiens (Human)
Length658 aa
IsoformsNo isoforms
Related PMIDs 24357059
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDRGTLPLAV11ALLLASCSLS21PTSLAETVHC31DLQPVGPERG41EVTYTTSQVS
51-10051KGCVAQAPNA61ILEVHVLFLE71FPTGPSQLEL81TLQASKQNGT91WPREVLLVLS
101-150101VNSSVFLHLQ111ALGIPLHLAY121NSSLVTFQEP131PGVNTTELPS141FPKTQILEWA
151-200151AERGPITSAA161ELNDPQSILL171RLGQAQGSLS181FCMLEASQDM191GRTLEWRPRT
201-250201PALVRGCHLE211GVAGHKEAHI221LRVLPGHSAG231PRTVTVKVEL241SCAPGDLDAV
251-300251LILQGPPYVS261WLIDANHNMQ271IWTTGEYSFK281IFPEKNIRGF291KLPDTPQGLL
301-350301GEARMLNASI311VASFVELPLA321SIVSLHASSC331GGRLQTSPAP341IQTTPPKDTC
351-400351SPELLMSLIQ361TKCADDAMTL371VLKKELVAHL381KCTITGLTFW391DPSCEAEDRG
401-450401DKFVLRSAYS411SCGMQVSASM421ISNEAVVNIL431SSSSPQRKKV441HCLNMDSLSF
451-500451QLGLYLSPHF461LQASNTIEPG471QQSFVQVRVS481PSVSEFLLQL491DSCHLDLGPE
501-550501GGTVELIQGR511AAKGNCVSLL521SPSPEGDPRF531SFLLHFYTVP541IPKTGTLSCT
551-600551VALRPKTGSQ561DQEVHRTVFM571RLNIISPDLS581GCTSKGLVLP591AVLGITFGAF
601-650601LIGALLTAAL611WYIYSHTRSP621SKREPVVAVA631APASSESSST641NHSIGSTQST
651-658651PCSTSSMA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
17 Prokaryotic membrane lipoprotein lipid attachment site profile. - -
GPS-Palm: 0.87
Deep-Palm: 0.98
30 - - -
Deep-Palm: 0.93
53 - - -
Deep-Palm: 0.93
182 - - -
GPS-Palm: 0.68
Deep-Palm: 0.97
207 - - -
GPS-Palm: 0.79
Deep-Palm: 0.94
242 - - -
Deep-Palm: 0.96
330 - - -
Deep-Palm: 0.95
350 - - -
Deep-Palm: 0.64
363 - - -
Deep-Palm: 0.95
382 - - -
GPS-Palm: 0.70
Deep-Palm: 0.94
394 - - -
Deep-Palm: 0.76
412 - - -
GPS-Palm: 0.78
Deep-Palm: 0.86
442 - - -
Deep-Palm: 0.87
493 - - -
Deep-Palm: 0.97
516 - - -
GPS-Palm: 0.72
Deep-Palm: 0.97
549 - - -
GPS-Palm: 0.91
Deep-Palm: 0.88
582 - - -
GPS-Palm: 0.83
Deep-Palm: 0.95
652 - - -
GPS-Palm: 0.73
Deep-Palm: 0.02
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HUVECs
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
288 R → C 0.001887 SNP Missense Mutation UCEC
394 C → _S407dup 0.003559 INS In Frame Ins KIRP
406 R → C 0.002506 SNP Missense Mutation COAD
554 R → C 0.001887 SNP Missense Mutation UCEC
586 G → C 0.002020 SNP Missense Mutation PRAD