Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P17980 | PSMC3 | 26S proteasome regulatory subunit 6A … | Homo sapiens (Human) | 439 aa |
Protein Details: P17980 (PSMC3)
Protein Information
| Accession | P17980 |
|---|---|
| Protein Names | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) |
| Gene Symbol | PSMC3 |
| Organism | Homo sapiens (Human) |
| Length | 439 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MNLLPNIESP11VTRQEKMATV21WDEAEQDGIG31EEVLKMSTEE41IIQRTRLLDS
51-10051EIKIMKSEVL61RVTHELQAMK71DKIKENSEKI81KVNKTLPYLV91SNVIELLDVD
101-150101PNDQEEDGAN111IDLDSQRKGK121CAVIKTSTRQ131TYFLPVIGLV141DAEKLKPGDL
151-200151VGVNKDSYLI161LETLPTEYDS171RVKAMEVDER181PTEQYSDIGG191LDKQIQELVE
201-250201AIVLPMNHKE211KFENLGIQPP221KGVLMYGPPG231TGKTLLARAC241AAQTKATFLK
251-300251LAGPQLVQMF261IGDGAKLVRD271AFALAKEKAP281SIIFIDELDA291IGTKRFDSEK
301-350301AGDREVQRTM311LELLNQLDGF321QPNTQVKVIA331ATNRVDILDP341ALLRSGRLDR
351-400351KIEFPMPNEE361ARARIMQIHS371RKMNVSPDVN381YEELARCTDD391FNGAQCKAVC
401-439401VEAGMIALRR411GATELTHEDY421MEGILEVQAK431KKANLQYYA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 121 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.76
|
|
| 240 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 387 | - | - | - |
Deep-Palm: 0.71
|
|
| 396 | - | - | - |
Deep-Palm: 0.94
|
|
| 400 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
HAP1 cell
Specificity: 0.667
2/2 (100.0%)
1
293T cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 132 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 264 | G → C | 0.002288 | SNP | Missense Mutation | STAD |
| 264 | G → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 396 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |