Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P17987 | TCP1 | T-complex protein 1 subunit alpha … | Homo sapiens (Human) | 556 aa |
Protein Details: P17987 (TCP1)
Protein Information
| Accession | P17987 |
|---|---|
| Protein Names | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) |
| Gene Symbol | TCP1 |
| Organism | Homo sapiens (Human) |
| Length | 556 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 31382980 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEGPLSVFGD11RSTGETIRSQ21NVMAAASIAN31IVKSSLGPVG41LDKMLVDDIG
51-10051DVTITNDGAT61ILKLLEVEHP71AAKVLCELAD81LQDKEVGDGT91TSVVIIAAEL
101-150101LKNADELVKQ111KIHPTSVISG121YRLACKEAVR131YINENLIVNT141DELGRDCLIN
151-200151AAKTSMSSKI161IGINGDFFAN171MVVDAVLAIK181YTDIRGQPRY191PVNSVNILKA
201-250201HGRSQMESML211ISGYALNCVV221GSQGMPKRIV231NAKIACLDFS241LQKTKMKLGV
251-300251QVVITDPEKL261DQIRQRESDI271TKERIQKILA281TGANVILTTG291GIDDMCLKYF
301-350301VEAGAMAVRR311VLKRDLKRIA321KASGATILST331LANLEGEETF341EAAMLGQAEE
351-400351VVQERICDDE361LILIKNTKAR371TSASIILRGA381NDFMCDEMER391SLHDALCVVK
401-450401RVLESKSVVP411GGGAVEAALS421IYLENYATSM431GSREQLAIAE441FARSLLVIPN
451-500451TLAVNAAQDS461TDLVAKLRAF471HNEAQVNPER481KNLKWIGLDL491SNGKPRDNKQ
501-550501AGVFEPTIVK511VKSLKFATEA521AITILRIDDL531IKLHPESKDD541KHGSYEDAVH
551-556551SGALND
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 76 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 125 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.68
|
|
| 147 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.86
|
| 218 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.73
|
|
| 236 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.96
Deep-Palm: 0.95
|
|
| 296 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.66
Deep-Palm: 0.95
|
|
| 357 | - |
SW480 cell line
(26865113)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.94
|
|
| 385 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.69
Deep-Palm: 0.60
|
|
| 397 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.88
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
cerebral cortex
Specificity: 0.222
4/4 (100.0%)
3
LNCaP
Specificity: 0.167
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.111
2/2 (100.0%)
1
U937 cell
Specificity: 0.056
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.056
1/1 (100.0%)
1
293T cell
Specificity: 0.056
1/1 (100.0%)
1
heart
Specificity: 0.056
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.222
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.056
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 130 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 236 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 390 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 414 | A → Cfs*11 | 0.001887 | INS | Frame Shift Ins | UCEC |
| 480 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| ? | ? → ? | 0.007299 | SNP | Nonstop Mutation | READ |