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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P17987 TCP1; CCT1; CCTA T-complex protein 1 subunit alpha … Homo sapiens (Human) 556 aa

Protein Details: P17987 (TCP1)

Protein Information
Accession P17987
Protein Names T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1)
Gene Symbol TCP1; CCT1; CCTA
Organism Homo sapiens (Human)
Length 556 aa
Isoforms No isoforms
Related PMIDs 19801377 21076176 29733200 31251020 31382980 32944167 33636221 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.448
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.448
26/46 (56.5%)
10
HAP1 cells
Specificity: 0.172
10/10 (100.0%)
6
Jurkat T cells
Specificity: 0.103
6/25 (24.0%)
4
PC3 cells
Specificity: 0.069
4/4 (100.0%)
4
293T cells
Specificity: 0.069
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.069
4/4 (100.0%)
2
DU145 cells
Specificity: 0.034
2/2 (100.0%)
1
U937 cells
Specificity: 0.017
1/1 (100.0%)
1
Liver membrane
Specificity: 0.017
1/1 (100.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MEGPLSVFGD11RSTGETIRSQ21NVMAAASIAN31IVKSSLGPVG41LDKMLVDDIG
51-10051DVTITNDGAT61ILKLLEVEHP71AAKVLCELAD81LQDKEVGDGT91TSVVIIAAEL
101-150101LKNADELVKQ111KIHPTSVISG121YRLACKEAVR131YINENLIVNT141DELGRDCLIN
151-200151AAKTSMSSKI161IGINGDFFAN171MVVDAVLAIK181YTDIRGQPRY191PVNSVNILKA
201-250201HGRSQMESML211ISGYALNCVV221GSQGMPKRIV231NAKIACLDFS241LQKTKMKLGV
251-300251QVVITDPEKL261DQIRQRESDI271TKERIQKILA281TGANVILTTG291GIDDMCLKYF
301-350301VEAGAMAVRR311VLKRDLKRIA321KASGATILST331LANLEGEETF341EAAMLGQAEE
351-400351VVQERICDDE361LILIKNTKAR371TSASIILRGA381NDFMCDEMER391SLHDALCVVK
401-450401RVLESKSVVP411GGGAVEAALS421IYLENYATSM431GSREQLAIAE441FARSLLVIPN
451-500451TLAVNAAQDS461TDLVAKLRAF471HNEAQVNPER481KNLKWIGLDL491SNGKPRDNKQ
501-550501AGVFEPTIVK511VKSLKFATEA521AITILRIDDL531IKLHPESKDD541KHGSYEDAVH
551-556551SGALND
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
76 Prediction (Medium) - -
125 Prediction (Medium) - -
147 CYSMODDB SWISSPALM DBPTM Prediction (High) - -
218 Prediction (Medium) - -
236 Prediction (High) - -
296 Prediction (Low) - -
357 Prediction (Medium) - -
385 Prediction (Low) - -
397 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
130 R → C 0.002506 SNP Missense Mutation COAD
236 C → R 0.001887 SNP Missense Mutation UCEC
390 R → C 0.002545 SNP Missense Mutation GBM
414 A → Cfs*11 0.001887 INS Frame Shift Ins UCEC
480 R → C 0.002506 SNP Missense Mutation COAD
? ? → ? 0.007299 SNP Nonstop Mutation READ