Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P19096 | Fasn | Fatty acid synthase (EC 2.3.1.85) … | Mus musculus (Mouse) | 2504 aa |
Protein Details: P19096 (Fasn)
Protein Information
| Accession | P19096 |
|---|---|
| Protein Names | Fatty acid synthase (EC 2.3.1.85) (Type I Fatty Acid Synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] |
| Gene Symbol | Fasn |
| Organism | Mus musculus (Mouse) |
| Length | 2504 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29733200 34200797 34884899 35358180 35477839 37925639 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEVVIAGMS11GKLPESENLQ21EFWANLIGGV31DMVTDDDRRW41KAGLYGLPKR
51-10051SGKLKDLSKF61DASFFGVHPK71QAHTMDPQLR81LLLEVSYEAI91VDGGINPASL
101-150101RGTNTGVWVG111VSGSEASEAL121SRDPETLLGY131SMVGCQRAMM141ANRLSFFFDF
151-200151KGPSIALDTA161CSSSLLALQN171AYQAIRSGEC181PAALVGGINL191LLKPNTSVQF
201-250201MKLGMLSPDG211TCRSFDDSGS221GYCRSEAVVA231VLLTKKSLAR241RVYATILNAG
251-300251TNTDGSKEQG261VTFPSGEVQE271QLICSLYQPA281GLAPESLEYI291EAHGTGTKVG
301-350301DPQELNGITR311SLCAFRQAPL321LIGSTKSNMG331HPEPASGLAA341LTKVLLSLEH
351-400351GVWAPNLHFH361NPNPEIPALL371DGRLQVVDRP381LPVRGGNVGI391NSFGFGGSNV
401-450401HVILQPNTRQ411APAPTAHAAL421PHLLHASGRT431LEAVQDLLEQ441GRQHSQDLAF
451-500451VSMLNDIAAT461PTAAMPFRGY471TVLGVEGRVQ481EVQQVSTNKR491PLWFICSGMG
501-550501TQWRGMGLSL511MRLDSFRESI521LRSDEAVKPL531GVKVSDLLLS541TDERTFDDIV
551-600551HAFVSLTAIQ561IALIDLLTSV571GLKPDGIIGH581SLGEVACGYA591DGCLSQREAV
601-650601LAAYWRGQCI611KDAHLPPGSM621AAVGLSWEEC631KQRCPAGVVP641ACHNSEDTVT
651-700651ISGPQAAVNE661FVEQLKQEGV671FAKEVRTGGL681AFHSYFMEGI691APTLLQALKK
701-750701VIREPRPRSA711RWLSTSIPEA721QWQSSLARTS731SAEYNVNNLV741SPVLFQEALW
751-800751HIPEHAVVLE761IAPHALLQAV771LKRGVKSSCT781IIPLMKRDHK791DNLEFFLTNL
801-850801GKVHLTGINV811NPNALFPPVE821FPAPRGTPLI831SPHIKWDHSQ841TWDVPVAEDF
851-900851PNGSSSSSAT861VYSIDASPES871PDHYLVDHCI881DGRVIFPGTG891YLCLVWKTLA
901-950901RSLGLSLEET911PVVFENVSFH921QATILPKTGT931VALEVRLLEA941SHAFEVSDTG
951-1000951NLIVSGKVYL961WEDPNSKLFD971HPEVPTPPES981ASVSRLTQGE991VYKELRLRGY
1001-10501001DYGPQFQGIC1011EATLEGEQGK1021LLWKDNWVTF1031MDTMLQVSIL1041GSSQQSLQLP
1051-11001051TRVTAIYIDP1061ATHRQKVYRL1071KEDTQVADVT1081TSRCLGITVS1091GGIHISRLQT
1101-11501101TATSRRQQEQ1111LVPTLEKFVF1121TPHMEAECLS1131ESTALQKELQ1141LCKGLARALQ
1151-12001151TKATQQGLKA1161AMLGQEDPPQ1171HGLPRLLAAA1181CQLQLNGNLQ1191LELGEALAQE
1201-12501201RLLLPEDPLI1211SGLLNSQALK1221ACVDTALENL1231STLKMKVAEV1241LAGEGHLYSR
1251-13001251IPALLNTQPM1261LQLEYTATDR1271HPQALKDVQT1281KLQQHDVAQG1291QWNPSDPAPS
1301-13501301SLGALDLLVC1311NCALATLGDP1321ALALDNMVAA1331LKEGGFLLVH1341TVLKGHALGE
1351-14001351TLACLPSEVQ1361PAPSLLSQEE1371WESLFSRKAL1381HLVGLKRSFY1391GTALFLCRRA
1401-14501401IPQEKPIFLS1411VEDTSFQWVD1421SLKSTLATSS1431SQPVWLTAMD1441CPTSGVVGLV
1451-15001451NCLRKEPGGH1461RIRCILLSNL1471SNTSHAPKLD1481PGSPELQQVL1491KHDLVMNVYR
1501-15501501DGAWGAFRHF1511QLEQDKPKEQ1521TAHAFVNVLT1531RGDLASIRWV1541SSPLKHTQPS
1551-16001551SSGAQLCTVY1561YASLNFRDIM1571LATGKLSPDA1581IPGKWASRDC1591MLGMEFSGRD
1601-16501601RCGRRVMGLV1611PAEGLATSVL1621LSSDFLWDVP1631SSWTLEEAAS1641VPVVYTTAYY
1651-17001651SLVVRGRIQR1661GETVLIHSGS1671GGVGQAAISI1681ALSLGCRVFT1691TVGSAEKRAY
1701-17501701LQARFPQLDD1711TSFANSRDTS1721FEQHVLLHTG1731GKGVDLVLNS1741LAEEKLQASV
1751-18001751RCLAQHGRFL1761EIGKFDLSNN1771HPLGMAIFLK1781NVTFHGILLD1791ALFEEANDSW
1801-18501801REVAALLKAG1811IRDGVVKPLK1821CTVFPKAQVE1831DAFRYMAQGK1841HIGKVLVQVR
1851-19001851EEEPEAVLPG1861AQPTLISAIS1871KTFCPAHKSY1881IITGGLGGFG1891LELARWLVLR
1901-19501901GAQRLVLTSR1911SGIRTGYQAK1921HIREWRRQGI1931QVLVSTSNVS1941SLEGARALIA
1951-20001951EATKLGPVGG1961VFNLAMVLRD1971AMLENQTPEL1981FQDVNKPKYN1991GTLNLDRATR
2001-20502001EACPELDYFV2011AFSSVSCGRG2021NAGQTNYGFA2031NSTMERICEQ2041RRHDGLPGLA
2051-21002051VQWGAIGDVG2061IVLEAMGTND2071TVIGGTLPQR2081ISSCMEVLDL2091FLNQPHAVLS
2101-21502101SFVLAEKKAV2111AHGDGDTQRD2121LVKAVAHILG2131IRDLAGINLD2141STLADLGLDS
2151-22002151LMGVEVRQIL2161EREHDLVLPM2171REVRQLTLRK2181LQEMSSKTDS2191ATDTTAPKSR
2201-22502201SDTSLKQNQL2211NLSTLLVNPE2221GPTLTQLNSV2231QSSERPLFLV2241HPIEGSTTVF
2251-23002251HSLAAKLSVP2261TYGLQCTQAA2271PLDSIPNLAA2281YYIDCIKQVQ2291PEGPYRIAGY
2301-23502301SFGACVAFEM2311CSQLQAQQGP2321APTHNNLFLF2331DGSHTYVLAY2341TQSYRAKMTP
2351-24002351GCEAEAEAEA2361LCFFIKQFLD2371VEHSKVLEAL2381LPLKSLEDRV2391AASVDLITKS
2401-24502401HHSLDRRELS2411FAAVSFYHKL2421RAADQYKPKA2431KYHGNVTLLR2441AKTGGTYGED
2451-25002451LGADYNLSQV2461CDGKVSVHII2471EGDHRTLLEG2481SGLESIINII2491HSSLAEPRVS
2501-25042501VREG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 135 | SWISSPALM DBPTM CYSMODDB | Beta-ketoacyl synthase N-terminal domain |
Liver
(28526873)
| - |
GPS-Palm: 0.89
Deep-Palm: 0.92
|
| 161 | SWISSPALM DBPTM CYSMODDB | Beta-ketoacyl synthase N-terminal domain |
Liver
(28526873)
| - |
GPS-Palm: 0.80
Deep-Palm: 0.92
|
| 180 | SWISSPALM DBPTM CYSMODDB | Beta-ketoacyl synthase, N-terminal domain |
Forebrain
(28680068)
| - |
GPS-Palm: 0.72
Deep-Palm: 0.98
|
| 212 | SWISSPALM DBPTM CYSMODDB | Beta-ketoacyl synthase N-terminal domain |
MLE
(39008777)
Liver
(28526873)
|
Brain
(35358180)
|
Deep-Palm: 0.90
|
| 223 | SWISSPALM DBPTM CYSMODDB | Beta-ketoacyl synthase N-terminal domain |
Liver
(28526873)
liver
(26165157)
|
Liver
(37925639)
Brain
(35358180)
|
Deep-Palm: 0.94
|
| 274 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.93
|
|
| 313 | Beta-ketoacyl synthase C-terminal domain |
Brain
(34200797)
| - |
GPS-Palm: 0.77
Deep-Palm: 0.90
|
|
| 496 | SWISSPALM DBPTM CYSMODDB | Acyl transferase domain |
Liver
(28526873)
| - |
GPS-Palm: 0.89
Deep-Palm: 0.59
|
| 587 | - | - | - |
Deep-Palm: 0.73
|
|
| 593 | - | - | - |
Deep-Palm: 0.77
|
|
| 609 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.90
|
|
| 630 | - | - | - |
Deep-Palm: 0.64
|
|
| 634 | - |
MLE
(39008777)
| - |
Deep-Palm: 0.40
|
|
| 642 | - |
MLE
(39008777)
| - |
Deep-Palm: 0.72
|
|
| 779 | SWISSPALM DBPTM CYSMODDB | Acyl transferase domain |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.94
Deep-Palm: 0.97
|
| 879 | - | - | - |
Deep-Palm: 0.92
|
|
| 893 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.97
|
|
| 1010 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.89
|
|
| 1084 | - | - | - |
Deep-Palm: 0.94
|
|
| 1128 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
Forebrain
(28680068)
|
Liver
(34884899)
Brain
(35358180)
|
Deep-Palm: 0.93
|
| 1142 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.97
|
|
| 1181 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 1222 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
|
Brain
(35358180)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 1310 | - | - | - |
Deep-Palm: 0.99
|
|
| 1312 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.98
|
|
| 1354 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
|
Liver
(34884899)
|
Deep-Palm: 0.97
|
| 1397 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
| - |
GPS-Palm: 0.94
Deep-Palm: 0.95
|
| 1441 | SWISSPALM DBPTM CYSMODDB | Fatty acid synthase pseudo-KR domain |
Liver
(28526873)
| - |
Deep-Palm: 0.98
|
| 1452 | SWISSPALM DBPTM CYSMODDB | Fatty acid synthase pseudo-KR domain |
Liver
(28526873)
| - |
GPS-Palm: 0.91
Deep-Palm: 0.98
|
| 1464 | Fatty acid synthase pseudo-KR domain |
Brain
(34200797)
| - |
GPS-Palm: 0.72
Deep-Palm: 0.97
|
|
| 1557 | - | - | - |
Deep-Palm: 0.45
|
|
| 1590 | - | - |
Brain
(35358180)
|
GPS-Palm: 0.83
Deep-Palm: 0.80
|
|
| 1602 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.95
|
|
| 1686 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.98
|
|
| 1752 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.98
|
|
| 1821 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.96
|
|
| 1874 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.88
|
|
| 2003 | - | - | - |
Deep-Palm: 0.91
|
|
| 2017 | SWISSPALM DBPTM CYSMODDB | KR domain |
Forebrain
(28680068)
| - |
Deep-Palm: 0.93
|
| 2038 | - | - | - |
Deep-Palm: 0.91
|
|
| 2084 | - | - | - |
Deep-Palm: 0.85
|
|
| 2266 | - | - | - |
Deep-Palm: 0.97
|
|
| 2285 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.62
|
|
| 2305 | - | - | - |
Deep-Palm: 0.66
|
|
| 2311 | - | - | - |
Deep-Palm: 0.34
|
|
| 2352 | SWISSPALM DBPTM CYSMODDB | - |
Forebrain
(28680068)
| - |
Deep-Palm: 0.85
|
| 2362 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.89
|
|
| 2461 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
| - |
Deep-Palm: 0.64
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
6
Liver
Specificity: 0.250
6/6 (100.0%)
4
Brain
Specificity: 0.167
4/4 (100.0%)
2
Testis
Specificity: 0.083
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
6
Brain tissue (Mass)
Specificity: 0.250
6/56 (10.7%)
6
Liver tissue (Mass)
Specificity: 0.250
6/8 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.