Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P19221 F2; Cf2 Prothrombin (EC 3.4.21.5) (Coagulation factor … Mus musculus (Mouse) 618 aa

Protein Details: P19221 (F2)

Protein Information
Accession P19221
Protein Names Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Gene Symbol F2; Cf2
Organism Mus musculus (Mouse)
Length 618 aa
Isoforms No isoforms
Related PMIDs 26165157 37925639
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
12
Liver tissue
Specificity: 1.000
12/19 (63.2%)
0
Brain tissue
Specificity: 0.000
0/12 (0.0%)
0
Macrophage Raw 264.7
Specificity: 0.000
0/2 (0.0%)
0
Neural Stem Cells
Specificity: 0.000
0/3 (0.0%)
0
Testis
Specificity: 0.000
0/2 (0.0%)
0
Liver membrane
Specificity: 0.000
0/6 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSHVRGLGLP11GCLALAALVS21LVHSQHVFLA31PQQALSLLQR41VRRANSGFLE
51-10051ELRKGNLERE61CVEEQCSYEE71AFEALESPQD81TDVFWAKYTV91CDSVRKPRET
101-150101FMDCLEGRCA111MDLGVNYLGT121VNVTHTGIQC131QLWRSRYPHK141PEINSTTHPG
151-200151ADLKENFCRN161PDSSTTGPWC171YTTDPTVRRE181ECSVPVCGQE191GRTTVVMTPR
201-250201SGGSKDNLSP211PLGQCLTERG221RLYQGNLAVT231TLGSPCLPWN241SLPAKTLSKY
251-300251QDFDPEVKLV261ENFCRNPDWD271EEGAWCYVAG281QPGDFEYCNL291NYCEEAVGEE
301-350301NYDVDESIAG311RTTDAEFHTF321FNEKTFGLGE331ADCGLRPLFE341KKSLKDTTEK
351-400351ELLDSYIDGR361IVEGWDAEKG371IAPWQVMLFR381KSPQELLCGA391SLISDRWVLT
401-450401AAHCILYPPW411DKNFTENDLL421VRIGKHSRTR431YERNVEKISM441LEKIYVHPRY
451-500451NWRENLDRDI461ALLKLKKPVP471FSDYIHPVCL481PDKQTVTSLL491RAGYKGRVTG
501-550501WGNLRETWTT511NINEIQPSVL521QVVNLPIVER531PVCKASTRIR541ITDNMFCAGF
551-600551KVNDTKRGDA561CEGDSGGPFV571MKSPFNNRWY581QMGIVSWGEG591CDRKGKYGFY
601-618601THVFRLKRWI611QKVIDQFG
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
12 Prediction (High) - -
91 Prediction (Medium) - -
130 Prediction (Medium) - -
182 Experimental CYSMODDB SWISSPALM DBPTM Kringle domain 26165157
187 Experimental - 26165157
215 Prediction (Low) - -
236 Prediction (Medium) - -
333 Prediction (Medium) - -
388 Prediction (Medium) - -
533 Prediction (Low) - -
547 Prediction (Medium) - -
591 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
52 R → C 0.002288 SNP Missense Mutation STAD
87 Y → C 0.001887 SNP Missense Mutation UCEC
129 C → C 0.005618 SNP Silent PAAD
135 R → C 0.001887 SNP Missense Mutation UCEC
158 R → C 0.002288 SNP Missense Mutation STAD
198 R → C 0.002294 SNP Missense Mutation OV
198 R → C 0.001887 SNP Missense Mutation UCEC
201 G → C 0.002288 SNP Missense Mutation STAD
363 R → C 0.001764 SNP Missense Mutation LUAD
482 C → R 0.001887 SNP Missense Mutation UCEC
511 W → C 0.002033 SNP Missense Mutation LUSC
578 F → C 0.002288 SNP Missense Mutation STAD