Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P19221 | F2 | Prothrombin (EC 3.4.21.5) (Coagulation factor … | Mus musculus (Mouse) | 618 aa |
Protein Details: P19221 (F2)
Protein Information
| Accession | P19221 |
|---|---|
| Protein Names | Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] |
| Gene Symbol | F2 |
| Organism | Mus musculus (Mouse) |
| Length | 618 aa |
| Isoforms | No isoforms |
| Related PMIDs | 37925639 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSHVRGLGLP11GCLALAALVS21LVHSQHVFLA31PQQALSLLQR41VRRANSGFLE
51-10051ELRKGNLERE61CVEEQCSYEE71AFEALESPQD81TDVFWAKYTV91CDSVRKPRET
101-150101FMDCLEGRCA111MDLGVNYLGT121VNVTHTGIQC131QLWRSRYPHK141PEINSTTHPG
151-200151ADLKENFCRN161PDSSTTGPWC171YTTDPTVRRE181ECSVPVCGQE191GRTTVVMTPR
201-250201SGGSKDNLSP211PLGQCLTERG221RLYQGNLAVT231TLGSPCLPWN241SLPAKTLSKY
251-300251QDFDPEVKLV261ENFCRNPDWD271EEGAWCYVAG281QPGDFEYCNL291NYCEEAVGEE
301-350301NYDVDESIAG311RTTDAEFHTF321FNEKTFGLGE331ADCGLRPLFE341KKSLKDTTEK
351-400351ELLDSYIDGR361IVEGWDAEKG371IAPWQVMLFR381KSPQELLCGA391SLISDRWVLT
401-450401AAHCILYPPW411DKNFTENDLL421VRIGKHSRTR431YERNVEKISM441LEKIYVHPRY
451-500451NWRENLDRDI461ALLKLKKPVP471FSDYIHPVCL481PDKQTVTSLL491RAGYKGRVTG
501-550501WGNLRETWTT511NINEIQPSVL521QVVNLPIVER531PVCKASTRIR541ITDNMFCAGF
551-600551KVNDTKRGDA561CEGDSGGPFV571MKSPFNNRWY581QMGIVSWGEG591CDRKGKYGFY
601-618601THVFRLKRWI611QKVIDQFG
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.92
|
|
| 61 | - | - | - |
Deep-Palm: 0.95
|
|
| 66 | - | - | - |
Deep-Palm: 0.69
|
|
| 91 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.38
|
|
| 104 | - | - | - |
Deep-Palm: 0.56
|
|
| 109 | - | - | - |
Deep-Palm: 0.31
|
|
| 130 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.10
|
|
| 158 | - | - | - |
Deep-Palm: 0.10
|
|
| 170 | - | - |
Liver
(34884899)
|
Deep-Palm: 0.10
|
|
| 182 | SWISSPALM DBPTM CYSMODDB | Kringle domain |
liver
(26165157)
| - |
Deep-Palm: 0.43
|
| 187 | - | - | - |
Deep-Palm: 0.86
|
|
| 215 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.96
|
|
| 236 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.70
|
|
| 264 | - | - | - |
Deep-Palm: 0.09
|
|
| 276 | - | - | - |
Deep-Palm: 0.05
|
|
| 288 | - | - | - |
Deep-Palm: 0.05
|
|
| 293 | - | - | - |
Deep-Palm: 0.05
|
|
| 333 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.94
|
|
| 388 | - | - |
Brain
(35358180)
|
GPS-Palm: 0.88
Deep-Palm: 0.85
|
|
| 404 | - | - | - |
Deep-Palm: 0.43
|
|
| 479 | - | - | - |
Deep-Palm: 0.89
|
|
| 533 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.82
|
|
| 547 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.25
|
|
| 561 | - | - |
Brain
(35358180)
|
Deep-Palm: 0.10
|
|
| 591 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.04
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Liver
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 52 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 87 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 129 | C → C | 0.005618 | SNP | Silent | PAAD |
| 135 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 158 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 198 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 198 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 201 | G → C | 0.002288 | SNP | Missense Mutation | STAD |
| 363 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 482 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |
| 511 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 578 | F → C | 0.002288 | SNP | Missense Mutation | STAD |