Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P20645 | M6PR | Cation-dependent mannose-6-phosphate receptor (CD Man-6-P … | Homo sapiens (Human) | 277 aa |
Protein Details: P20645 (M6PR)
Protein Information
| Accession | P20645 |
|---|---|
| Protein Names | Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) |
| Gene Symbol | M6PR |
| Organism | Homo sapiens (Human) |
| Length | 277 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 26111759 31251020 31382980 32651440 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFPFYSCWRT11GLLLLLLAVA21VRESWQTEEK31TCDLVGEKGK41ESEKELALVK
51-10051RLKPLFNKSF61ESTVGQGSDT71YIYIFRVCRE81AGNHTSGAGL91VQINKSNGKE
101-150101TVVGRLNETH111IFNGSNWIML121IYKGGDEYDN131HCGKEQRRAV141VMISCNRHTL
151-200151ADNFNPVSEE161RGKVQDCFYL171FEMDSSLACS181PEISHLSVGS191ILLVTFASLV
201-250201AVYVVGGFLY211QRLVVGAKGM221EQFPHLAFWQ231DLGNLVADGC241DFVCRSKPRN
251-277251VPAAYRGVGD261DQLGEESEER271DDHLLPM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 7 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.05
|
|
| 32 | Cation-dependent mannose-6-phosphate receptor Mannose-6-phosphate receptor | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 78 | - | - | - |
Deep-Palm: 0.78
|
|
| 132 | - | - | - |
Deep-Palm: 0.07
|
|
| 145 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.31
|
|
| 167 | - | - | - |
Deep-Palm: 0.40
|
|
| 179 | - | - | - |
Deep-Palm: 0.80
|
|
| 240 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.93
Deep-Palm: 0.91
|
|
| 244 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.91
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.316
6
Jurkat T cell
Specificity: 0.300
6/6 (100.0%)
4
LNCaP
Specificity: 0.200
4/4 (100.0%)
4
Primary T cell
Specificity: 0.200
4/4 (100.0%)
2
cerebral cortex
Specificity: 0.100
2/2 (100.0%)
1
U937 cell
Specificity: 0.050
1/1 (100.0%)
1
heart
Specificity: 0.050
1/1 (100.0%)
1
HUVECs
Specificity: 0.050
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.050
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 256 | R → C | 0.002506 | SNP | Missense Mutation | COAD |