Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 (S1P … | Homo sapiens (Human) | 382 aa |
Protein Details: P21453 (S1PR1)
Protein Information
| Accession | P21453 |
|---|---|
| Protein Names | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) |
| Gene Symbol | S1PR1 |
| Organism | Homo sapiens (Human) |
| Length | 382 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 33636221 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGPTSVPLVK11AHRSSVSDYV21NYDIIVRHYN31YTGKLNISAD41KENSIKLTSV
51-10051VFILICCFII61LENIFVLLTI71WKTKKFHRPM81YYFIGNLALS91DLLAGVAYTA
101-150101NLLLSGATTY111KLTPAQWFLR121EGSMFVALSA131SVFSLLAIAI141ERYITMLKMK
151-200151LHNGSNNFRL161FLLISACWVI171SLILGGLPIM181GWNCISALSS191CSTVLPLYHK
201-250201HYILFCTTVF211TLLLLSIVIL221YCRIYSLVRT231RSRRLTFRKN241ISKASRSSEK
251-300251SLALLKTVII261VLSVFIACWA271PLFILLLLDV281GCKVKTCDIL291FRAEYFLVLA
301-350301VLNSGTNPII311YTLTNKEMRR321AFIRIMSCCK331CPSGDSAGKF341KRPIIAGMEF
351-382351SRSKSDNSSH361PQKDEGDNPE371TIMSSGNVNS381SS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 56 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.16
|
|
| 57 | - | - | - |
Deep-Palm: 0.13
|
|
| 167 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.70
|
|
| 184 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.90
|
|
| 191 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.17
|
|
| 206 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.37
|
|
| 222 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.96
|
|
| 268 | - | - | - |
Deep-Palm: 0.70
|
|
| 282 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
|
| 287 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.96
|
|
| 328 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.80
|
| 329 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.72
|
| 331 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.82
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
heart
Specificity: 0.500
1/1 (100.0%)
1
HUVECs
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 142 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 171 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 192 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 222 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 282 | C → C | 0.001764 | SNP | Silent | LUAD |
| 319 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 331 | C → C | 0.005587 | SNP | Silent | PCPG |