Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P21453 | S1PR1; CHEDG1; EDG1 | Sphingosine 1-phosphate receptor 1 (S1P … | Homo sapiens (Human) | 382 aa |
Protein Details: P21453 (S1PR1)
Protein Information
| Accession | P21453 |
|---|---|
| Protein Names | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) |
| Gene Symbol | S1PR1; CHEDG1; EDG1 |
| Organism | Homo sapiens (Human) |
| Length | 382 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 33636221 36430497 |
| Database Sources | dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
2
Cerebral cortex
Specificity: 0.500
2/4 (50.0%)
1
Endothelial cells
Specificity: 0.250
1/2 (50.0%)
1
Liver membrane
Specificity: 0.250
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGPTSVPLVK11AHRSSVSDYV21NYDIIVRHYN31YTGKLNISAD41KENSIKLTSV
51-10051VFILICCFII61LENIFVLLTI71WKTKKFHRPM81YYFIGNLALS91DLLAGVAYTA
101-150101NLLLSGATTY111KLTPAQWFLR121EGSMFVALSA131SVFSLLAIAI141ERYITMLKMK
151-200151LHNGSNNFRL161FLLISACWVI171SLILGGLPIM181GWNCISALSS191CSTVLPLYHK
201-250201HYILFCTTVF211TLLLLSIVIL221YCRIYSLVRT231RSRRLTFRKN241ISKASRSSEK
251-300251SLALLKTVII261VLSVFIACWA271PLFILLLLDV281GCKVKTCDIL291FRAEYFLVLA
301-350301VLNSGTNPII311YTLTNKEMRR321AFIRIMSCCK331CPSGDSAGKF341KRPIIAGMEF
351-382351SRSKSDNSSH361PQKDEGDNPE371TIMSSGNVNS381SS
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 56 | Prediction (Low) | - | - |
| 167 | Prediction (Low) | - | - |
| 184 | Prediction (Low) | - | - |
| 191 | Prediction (Low) | - | - |
| 206 | Prediction (Low) | - | - |
| 222 | Prediction (High) | - | - |
| 282 | Prediction (High) | - | - |
| 287 | Prediction (Medium) | - | - |
| 328 | DBPTM SWISSPALM Prediction (High) | - | - |
| 329 | DBPTM SWISSPALM Prediction (High) | - | - |
| 331 | DBPTM SWISSPALM Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 142 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 171 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 192 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 222 | C → Y | 0.002506 | SNP | Missense Mutation | COAD |
| 282 | C → C | 0.001764 | SNP | Silent | LUAD |
| 319 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 331 | C → C | 0.005587 | SNP | Silent | PCPG |