Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P21980 TGM2 Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) … Homo sapiens (Human) 687 aa

Protein Details: P21980 (TGM2)

Protein Information
AccessionP21980
Protein NamesProtein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)
Gene SymbolTGM2
OrganismHomo sapiens (Human)
Length687 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAEELVLERC11DLELETNGRD21HHTADLCREK31LVVRRGQPFW41LTLHFEGRNY
51-10051EASVDSLTFS61VVTGPAPSQE71AGTKARFPLR81DAVEEGDWTA91TVVDQQDCTL
101-150101SLQLTTPANA111PIGLYRLSLE121ASTGYQGSSF131VLGHFILLFN141AWCPADAVYL
151-200151DSEEERQEYV161LTQQGFIYQG171SAKFIKNIPW181NFGQFEDGIL191DICLILLDVN
201-250201PKFLKNAGRD211CSRRSSPVYV221GRVVSGMVNC231NDDQGVLLGR241WDNNYGDGVS
251-300251PMSWIGSVDI261LRRWKNHGCQ271RVKYGQCWVF281AAVACTVLRC291LGIPTRVVTN
301-350301YNSAHDQNSN311LLIEYFRNEF321GEIQGDKSEM331IWNFHCWVES341WMTRPDLQPG
351-400351YEGWQALDPT361PQEKSEGTYC371CGPVPVRAIK381EGDLSTKYDA391PFVFAEVNAD
401-450401VVDWIQQDDG411SVHKSINRSL421IVGLKISTKS431VGRDEREDIT441HTYKYPEGSS
451-500451EEREAFTRAN461HLNKLAEKEE471TGMAMRIRVG481QSMNMGSDFD491VFAHITNNTA
501-550501EEYVCRLLLC511ARTVSYNGIL521GPECGTKYLL531NLNLEPFSEK541SVPLCILYEK
551-600551YRDCLTESNL561IKVRALLVEP571VINSYLLAER581DLYLENPEIK591IRILGEPKQK
601-650601RKLVAEVSLQ611NPLPVALEGC621TFTVEGAGLT631EEQKTVEIPD641PVEAGEEVKV
651-687651RMDLLPLHMG661LHKLVVNFES671DKLKAVKGFR681NVIIGPA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
10 Immunoglobulin-like fold Immunoglobulin E-set Transglutaminase, N-terminal - -
Deep-Palm: 0.03
27 Immunoglobulin-like fold Immunoglobulin E-set Transglutaminase, N-terminal - -
GPS-Palm: 0.75
Deep-Palm: 0.94
98 - - -
Deep-Palm: 0.60
143 - - -
Deep-Palm: 0.65
193 - - -
GPS-Palm: 0.68
Deep-Palm: 0.74
211 - - -
GPS-Palm: 0.75
Deep-Palm: 0.95
230 -
SW480 cell line (26865113)
-
Deep-Palm: 0.64
269 - - -
GPS-Palm: 0.67
Deep-Palm: 0.19
277 - - -
Deep-Palm: 0.13
285 - - -
GPS-Palm: 0.70
Deep-Palm: 0.78
290 - - -
GPS-Palm: 0.82
Deep-Palm: 0.70
336 - - -
Deep-Palm: 0.04
370 - -
cerebral cortex (36430497)
GPS-Palm: 0.68
Deep-Palm: 0.94
371 - -
cerebral cortex (36430497)
GPS-Palm: 0.79
Deep-Palm: 0.93
505 - - -
GPS-Palm: 0.80
Deep-Palm: 0.65
510 - - -
GPS-Palm: 0.67
Deep-Palm: 0.80
524 -
SW480 cell line (26865113)
-
GPS-Palm: 0.75
Deep-Palm: 0.89
545 -
SW480 cell line (26865113)
-
GPS-Palm: 0.83
Deep-Palm: 0.90
554 SWISSPALM DBPTM CYSMODDB Transglutaminase family C-terminal ig like domain
SW480 cell line (26865113)
-
GPS-Palm: 0.88
Deep-Palm: 0.97
620 - - -
Deep-Palm: 0.97
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
48 R → C 0.002020 SNP Missense Mutation PRAD
124 G → C 0.002506 SNP Missense Mutation COAD
213 R → C 0.001887 SNP Missense Mutation UCEC
221 G → C 0.001969 SNP Missense Mutation HNSC
240 R → C 0.001887 SNP Missense Mutation UCEC
263 R → C 0.001969 SNP Missense Mutation HNSC
263 R → C 0.002506 SNP Missense Mutation COAD
269 C → S 0.002427 SNP Missense Mutation BLCA
271 R → C 0.002288 SNP Missense Mutation STAD
271 R → delinsLPPTTCSVTLS 0.002294 INS In Frame Ins OV
317 R → C 0.002506 SNP Missense Mutation COAD
377 R → C 0.002141 SNP Missense Mutation SKCM
377 R → C 0.003774 SNP Missense Mutation UCEC
382 G → C 0.001764 SNP Missense Mutation LUAD
545 C → W 0.001887 SNP Missense Mutation UCEC
628 G → C 0.001014 SNP Missense Mutation BRCA