Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P22460 | KCNA5 | Potassium voltage-gated channel subfamily A … | Homo sapiens (Human) | 613 aa |
Protein Details: P22460 (KCNA5)
Protein Information
| Accession | P22460 |
|---|---|
| Protein Names | Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) |
| Gene Symbol | KCNA5 |
| Organism | Homo sapiens (Human) |
| Length | 613 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEIALVPLEN11GGAMTVRGGD21EARAGCGQAT31GGELQCPPTA41GLSDGPKEPA
51-10051PKGRGAQRDA61DSGVRPLPPL71PDPGVRPLPP81LPEELPRPRR91PPPEDEEEEG
101-150101DPGLGTVEDQ111ALGTASLHHQ121RVHINISGLR131FETQLGTLAQ141FPNTLLGDPA
151-200151KRLRYFDPLR161NEYFFDRNRP171SFDGILYYYQ181SGGRLRRPVN191VSLDVFADEI
201-250201RFYQLGDEAM211ERFREDEGFI221KEEEKPLPRN231EFQRQVWLIF241EYPESSGSAR
251-300251AIAIVSVLVI261LISIITFCLE271TLPEFRDERE281LLRHPPAPHQ291PPAPAPGANG
301-350301SGVMAPPSGP311TVAPLLPRTL321ADPFFIVETT331CVIWFTFELL341VRFFACPSKA
351-400351GFSRNIMNII361DVVAIFPYFI371TLGTELAEQQ381PGGGGGGQNG391QQAMSLAILR
401-450401VIRLVRVFRI411FKLSRHSKGL421QILGKTLQAS431MRELGLLIFF441LFIGVILFSS
451-500451AVYFAEADNQ461GTHFSSIPDA471FWWAVVTMTT481VGYGDMRPIT491VGGKIVGSLC
501-550501AIAGVLTIAL511PVPVIVSNFN521YFYHRETDHE531EPAVLKEEQG541TQSQGPGLDR
551-600551GVQRKVSGSR561GSFCKAGGTL571ENADSARRGS581CPLEKCNVKA591KSNVDLRRSL
601-613601YALCLDTSRE611TDL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 26 | Potassium channel, voltage dependent, Kv1.5 | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.92
|
|
| 36 | Potassium channel, voltage dependent, Kv1.5 | - | - |
Deep-Palm: 0.91
|
|
| 268 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.90
|
|
| 331 | - | - | - |
Deep-Palm: 0.10
|
|
| 346 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.22
|
|
| 500 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.93
|
|
| 564 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.96
|
|
| 581 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.94
|
|
| 586 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.90
|
|
| 604 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.25
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 1.000
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 136 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 152 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 154 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 154 | R → C | 0.005660 | SNP | Missense Mutation | UCEC |
| 154 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 167 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 184 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 201 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 212 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 229 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 234 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 279 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 308 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 342 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 346 | C → S | 0.001014 | SNP | Missense Mutation | BRCA |
| 403 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 415 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 415 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 472 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 497 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 268* | C → ? | 0.001887 | SNP | Nonsense Mutation | UCEC |