Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P22695 | UQCRC2 | Cytochrome b-c1 complex subunit 2, … | Homo sapiens (Human) | 453 aa |
Protein Details: P22695 (UQCRC2)
Protein Information
| Accession | P22695 |
|---|---|
| Protein Names | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) |
| Gene Symbol | UQCRC2 |
| Organism | Homo sapiens (Human) |
| Length | 453 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29733200 31251020 32944167 33636221 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.530
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.530
35/46 (76.1%)
10
HAP1 cells
Specificity: 0.152
10/10 (100.0%)
10
293T cells
Specificity: 0.152
10/10 (100.0%)
4
Jurkat T cells
Specificity: 0.061
4/25 (16.0%)
4
Cerebral cortex
Specificity: 0.061
4/4 (100.0%)
2
PC3 cells
Specificity: 0.030
2/4 (50.0%)
1
Liver membrane
Specificity: 0.015
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MKLLTRAGSF11SRFYSLKVAP21KVKATAAPAG31APPQPQDLEF41TKLPNGLVIA
51-10051SLENYSPVSR61IGLFIKAGSR71YEDFSNLGTT81HLLRLTSSLT91TKGASSFKIT
101-150101RGIEAVGGKL111SVTATRENMA121YTVECLRGDV131DILMEFLLNV141TTAPEFRRWE
151-200151VADLQPQLKI161DKAVAFQNPQ171THVIENLHAA181AYRNALANPL191YCPDYRIGKV
201-250201TSEELHYFVQ211NHFTSARMAL221IGLGVSHPVL231KQVAEQFLNM241RGGLGLSGAK
251-300251ANYRGGEIRE261QNGDSLVHAA271FVAESAVAGS281AEANAFSVLQ291HVLGAGPHVK
301-350301RGSNTTSHLH311QAVAKATQQP321FDVSAFNASY331SDSGLFGIYT341ISQATAAGDV
351-400351IKAAYNQVKT361IAQGNLSNTD371VQAAKNKLKA381GYLMSVESSE391CFLEEVGSQA
401-450401LVAGSYMPPS411TVLQQIDSVA421NADIINAAKK431FVSGQKSMAA441SGNLGHTPFV
451-453451DEL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 125 | Prediction (Medium) | - | - |
| 192 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 147 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 333 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 382 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |