Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P22695 | UQCRC2 | Cytochrome b-c1 complex subunit 2, … | Homo sapiens (Human) | 453 aa |
Protein Details: P22695 (UQCRC2)
Protein Information
| Accession | P22695 |
|---|---|
| Protein Names | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) |
| Gene Symbol | UQCRC2 |
| Organism | Homo sapiens (Human) |
| Length | 453 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKLLTRAGSF11SRFYSLKVAP21KVKATAAPAG31APPQPQDLEF41TKLPNGLVIA
51-10051SLENYSPVSR61IGLFIKAGSR71YEDFSNLGTT81HLLRLTSSLT91TKGASSFKIT
101-150101RGIEAVGGKL111SVTATRENMA121YTVECLRGDV131DILMEFLLNV141TTAPEFRRWE
151-200151VADLQPQLKI161DKAVAFQNPQ171THVIENLHAA181AYRNALANPL191YCPDYRIGKV
201-250201TSEELHYFVQ211NHFTSARMAL221IGLGVSHPVL231KQVAEQFLNM241RGGLGLSGAK
251-300251ANYRGGEIRE261QNGDSLVHAA271FVAESAVAGS281AEANAFSVLQ291HVLGAGPHVK
301-350301RGSNTTSHLH311QAVAKATQQP321FDVSAFNASY331SDSGLFGIYT341ISQATAAGDV
351-400351IKAAYNQVKT361IAQGNLSNTD371VQAAKNKLKA381GYLMSVESSE391CFLEEVGSQA
401-450401LVAGSYMPPS411TVLQQIDSVA421NADIINAAKK431FVSGQKSMAA441SGNLGHTPFV
451-453451DEL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 125 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.78
|
|
| 192 | SWISSPALM DBPTM CYSMODDB | - |
SW480 cell line
(26865113)
|
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.92
|
| 391 | - | - | - |
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
LNCaP
Specificity: 0.188
3/3 (100.0%)
2
293T cell
Specificity: 0.125
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.062
1/1 (100.0%)
1
heart
Specificity: 0.062
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.062
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 147 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 333 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 382 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |