Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P23284 | PPIB | Peptidyl-prolyl cis-trans isomerase B (PPIase … | Homo sapiens (Human) | 216 aa |
Protein Details: P23284 (PPIB)
Protein Information
| Accession | P23284 |
|---|---|
| Protein Names | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) |
| Gene Symbol | PPIB |
| Organism | Homo sapiens (Human) |
| Length | 216 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 29733200 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLRLSERNMK11VLLAAALIAG21SVFFLLLPGP31SAADEKKKGP41KVTVKVYFDL
51-10051RIGDEDVGRV61IFGLFGKTVP71KTVDNFVALA81TGEKGFGYKN91SKFHRVIKDF
101-150101MIQGGDFTRG111DGTGGKSIYG121ERFPDENFKL131KHYGPGWVSM141ANAGKDTNGS
151-200151QFFITTVKTA161WLDGKHVVFG171KVLEGMEVVR181KVESTKTDSR191DKPLKDVIIA
201-216201DCGKIEVEKP211FAIAKE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 202 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.375
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.250
2/2 (100.0%)
1
U937 cell
Specificity: 0.125
1/1 (100.0%)
1
frontal cortex
Specificity: 0.125
1/1 (100.0%)
1
293T cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 5 | S → Cfs*31 | 0.002141 | INS | Frame Shift Ins | SKCM |
| 95 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 95 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 133 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |